Bidirectional alterations in ALFF across slow-5 and slow-4 frequencies in the brains of postherpetic neuralgia patients

Gu, Leyi; Hong, Shunda; Jiang, Jian; Liu, Jiaqi; Cao, Xianlong; Huang, Qing; Zeng, Xianjun; Zhou, Fuqing; Zhang, Daying

doi:10.2147/jpr.s179077

Cited by 22 publications

(21 citation statements)

References 43 publications

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“…Using resting-state functional magnetic resonance imaging (fMRI), highly similar frequency-dependent changes have been reported in multiple chronic pain conditions. In trigeminal neuralgia [ 52 ], postherpetic neuralgia [ 12 ], and chronic back pain [ 28 , 51 ] populations, a loss of slow-5 power was not only noted in prefrontal cortex [ 52 ] but also in subcortical regions such as the nucleus accumbens, which share projections with sub-regions of the frontal cortex areas amongst other (meso-)limbic structures. Thus, in general, the suppression of the frontal cortex (potentially along the frontostriatal pathway) low-frequency oscillation in the slow-5 sub-band may represent a maladaptive cortical process that is derived from persistent pain or mechanisms that sustain a pain state.…”

Section: Discussionmentioning

confidence: 99%

Suppressed prefrontal cortex oscillations associate with clinical pain in fibrodysplasia ossificans progressiva

Peng

Karunakaran

Labadie

et al. 2021

Orphanet J Rare Dis

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Background Pain is a highly prevalent symptom experienced by patients across numerous rare musculoskeletal conditions. Much remains unknown regarding the central, neurobiological processes associated with clinical pain in musculoskeletal disease states. Fibrodysplasia ossificans progressiva (FOP) is an inherited condition characterized by substantial physical disability and pain. FOP arises from mutations of the bone morphogenetic protein (BMP) receptor Activin A receptor type 1 (ACVR1) causing patients to undergo painful flare-ups as well as heterotopic ossification (HO) of skeletal muscles, tendons, ligaments, and fascia. To date, the neurobiological processes that underlie pain in FOP have rarely been investigated. We examined pain and central pain mechanism in FOP as a model primary musculoskeletal condition. Central nervous system (CNS) functional properties were investigated in FOP patients (N = 17) stratified into low (0–3; 0–10 Scale) and high (≥ 4) pain cohorts using functional near-infrared spectroscopy (fNIRS). Associations among clinical pain, mental health, and physical health were also quantified using responses derived from a battery of clinical questionnaires. Results Resting-state fNIRS revealed suppressed power of hemodynamic activity within the slow-5 frequency sub-band (0.01–0.027 Hz) in the prefrontal cortex in high pain FOP patients, where reduced power of slow-5, prefrontal cortex oscillations exhibited robust negative correlations with pain levels. Higher clinical pain intensities were also associated with higher magnitudes of depressive symptoms. Conclusions Our findings not only demonstrate a robust coupling among prefrontal cortex functionality and clinical pain in FOP but lays the groundwork for utilizing fNIRS to objectively monitor and central pain mechanisms in FOP and other musculoskeletal disorders.

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Section: Discussionmentioning

confidence: 99%

Suppressed prefrontal cortex oscillations associate with clinical pain in fibrodysplasia ossificans progressiva

Peng

Karunakaran

Labadie

et al. 2021

Orphanet J Rare Dis

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“…Possible functional roles for the cerebellum relating to acupuncture modulation should be considered, including emotion, cognition, and motor control. Together with studies indicating a frequency-dependent modulation of BOLD signal oscillations in specific brain regions in patients with chronic pain (Wang et al, 2017;Rogachov et al, 2018;Gu et al, 2019), our study provides a practical rationale and mechanism for studying the frequency-dependence of BOLD oscillations in response to acupuncture analgesia.…”

Section: Discussionmentioning

confidence: 56%

Frequency-Specific Blood Oxygen Level Dependent Oscillations Associated With Pain Relief From Ankle Acupuncture in Patients With Chronic Low Back Pain

et al. 2021

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Objective: Recent advances in brain imaging have deepened our knowledge of the neural activity in distinct brain areas associated with acupuncture analgesia. However, there has not been conclusive research into the frequency-specific resting-state functional changes associated with acupuncture analgesia in patients with chronic pain. Here, we aimed to characterize changes across multiple frequencies of resting-state cortical activity associated with ankle acupuncture stimulation (AAS) in patients with chronic low back pain (CLBP) and healthy controls.Methods: Twenty seven patients with CLBP and Twenty five age- and gender-matched healthy volunteers were enrolled in the study. Participants received tactile sham acupuncture (TSA) and AAS, respectively. The whole-brain amplitude of low-frequency fluctuation (ALFF) in the range 0.01–0.25 Hz was assessed for changes associated with each intervention. Further, a visual analog scale (VAS) was used to collect subjective measures of pain intensity in patients. Linear mixed-effect modeling (LME) was used to examine the mean ALFF values of AAS and TSA between patients and healthy controls.Results: The ALFF was modulated in the default mode network (an increase in the medial prefrontal cortex, and a decrease in the cerebellum/posterior ingulate/parahippocampus, P < 0.01, corrected) in both patients and controls. Decreased ALFF in the bilateral insular was frequency-dependent. Modulations in the cerebellum and right insular were significantly correlated with VAS pain score after AAS (P < 0.01).Conclusion: Hence, frequency-specific resting-state activity in the cerebellum and insular was correlated to AAS analgesia. Our frequency-specific analysis of ALFF may provide novel insights related to pain relief from acupuncture.

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“…Decreased ACC, cuneus, and increased frontal lobe activity were found after treatment, which showed a reverse trend in PHN brain compared with healthy brain. 13,16 In addition, after treatment, FA values in the right superior temporal gyrus and AK values in the right middle temporal gyrus increased remarkably, which also showed a reverse trend in PHN brain compared with healthy brain. 20 These changes suggest that after a period of pain relief, for some differential brain regions, the functional and structural abnormalities in PHN brain may be reversible.…”

Section: Discussionmentioning

confidence: 95%

“…9 By using functional magnetic resonance imaging (fMRI), accumulating evidence showed functional abnormalities in PHN brain. [10][11][12][13][14] For example, functional connectivity analysis revealed altered connections between putamen and other regions in PHN brain. 11 Small-world network detection showed decreased local efficiency in sense, memory, and emotion-related brain areas in PHN brain.…”

Section: Introductionmentioning

confidence: 99%

<p>Functional and Structural Changes in Postherpetic Neuralgia Brain Before and Six Months After Pain Relieving</p>

Zhang

Cao

Yuan

et al. 2020

JPR

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Objective: Multimodal magnetic resonance imaging (MRI) was used to detect whether 6 months after pain relieving, the structural and functional abnormalities in the brain of postherpetic neuralgia (PHN) patients are changeable. Methods: Fifteen successfully treated PHN patients were enrolled; the brain activity and structural abnormalities were detected and compared before and 6 months after treatment. The functional parameters were evaluated with resting-state functional MRI technique, i.e., the regional homogeneity (ReHo) and fractional amplitude of low-frequency fluctuation (fALFF). Structural changes were detected with voxel-based morphometry (VBM) and diffusion kurtosis imaging (DKI). Results: Six months after pain relieving, PHN brain showed different ReHo and fALFF values in the frontal lobe, caudate, supramarginal gyrus, anterior cingulate cortex (ACC), cuneus, middle temporal gyrus, and cerebellum. In addition, VBM intensity in the cerebellum increased; DKI values decreased in the thalamus and increased in the temporal lobe after successful treatment. Conclusion: Six months after pain relieving, functional and structural changes exist in PHN brain. Changes in some differential areas in PHN brain, such as ACC, frontal lobe, thalamus, and temporal lobe indicate that the central plasticity may be reversible after chronic pain relieving.

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Bidirectional alterations in ALFF across slow-5 and slow-4 frequencies in the brains of postherpetic neuralgia patients

Cited by 22 publications

References 43 publications

Suppressed prefrontal cortex oscillations associate with clinical pain in fibrodysplasia ossificans progressiva

Suppressed prefrontal cortex oscillations associate with clinical pain in fibrodysplasia ossificans progressiva

Frequency-Specific Blood Oxygen Level Dependent Oscillations Associated With Pain Relief From Ankle Acupuncture in Patients With Chronic Low Back Pain

<p>Functional and Structural Changes in Postherpetic Neuralgia Brain Before and Six Months After Pain Relieving</p>

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