Bidentate Ligands for Enantioselective Enamide Reduction

Abstract

Scheme 9.1 The first catalytic asymmetric hydrogenation of enamide 1a reported by Kagan.Scheme 9.2 General methods for the synthesis of N-acyl-a-arylenamides. 274j 9 Bidentate Ligands for Enantioselective Enamide Reduction R O Scheme 9.4 Synthesis of exocyclic enamides. 9.2 Catalytic Enantioselective Hydrogenation of Enamides j275 4 15 Scheme 9.11 Rh-catalyzed asymmetric hydrogenation of ortho-substituted arylenamides with a triphosphorus bidentate phosphine-phosphoramidite ligand 49. 288j 9 Bidentate Ligands for Enantioselective Enamide Reduction P P P P Me-DuPhos Me-BPE 61 Scheme 9.15 Asymmetric hydrogenation of tetra-substituted cyclic enamides using the Ru-catalyst containing Me-DuPHOS or Me-BPE. 9.2 Catalytic Enantioselective Hydrogenation of Enamides j291