Bicyclic Systems with Two Bridgehead (Ring Junction) Nitrogen Atoms

Rádl, S.

doi:10.1016/b978-008044992-0.01110-x

Cited by 3 publications

(1 citation statement)

References 346 publications

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“…Importantly, the fluorescence of the halogenated bimane species is effectively quenched, making them particularly suitable for use as fluorescent labelling agents. 33–35 The choice of NBD as counter FRET entity is guided by requiring a moiety that features a comparable fluorescence intensity and shifted emission spectrum compared to the bimane species. We initially demonstrate that the molecular FRET pair 1 functions in organic solvents, specifically tetrahydrofuran (THF), yet shows no FRET activity in aqueous solution.…”

Section: Introductionmentioning

confidence: 99%

Förster resonance energy transfer within single chain nanoparticles

Maag,

Feist,

Frisch

et al. 2024

Chem. Sci.

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Section: Introductionmentioning

confidence: 99%

Förster resonance energy transfer within single chain nanoparticles

Maag,

Feist,

Frisch

et al. 2024

Chem. Sci.

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Synthesis of Chiral Diazabicycloalkanes via Organocatalytic aza‐Michael/Aldol Reaction

Scharinger,

Weil,

Schnürch

et al. 2023

Adv Synth Catal

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We introduce a strategy for the one‐step synthesis of chiral diazabicycloalkanes that delivers the annulated ring system in a single reaction step. The method entails a direct aza‐Michael/aldol reaction of enals in conjunction with modified oxopropanamides and establishes the chiral center via iminium‐enamine tandem catalysis. For this purpose, we developed simple diphenylethylendiamine frameworks as dual activation organocatalyst, effectively engaging both the substrate and reagent, thus leading to yields of 31–86% and enantioselectivities in the range of 80–98%. The final product features not only the diazabicycloalkane moiety but includes also additional functionalities, such as aldehyde motives that can be modified in situ without loss of enantioselectivity, and an sp2‐bearing methyl group. Our approach accommodates a wide array of enals with high functional group tolerance. Additionally, we demonstrated the adjustability of enantioselectivity and yield by modulating the acid cocatalyst‘s quantity, thus offering multiple optimization possibilities.

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Indazole and its Derivatives in Cardiovascular Diseases: Overview, Current Scenario, and Future Perspectives

Uppulapu

Alam

Kumar

et al. 2022

CTMC

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: Indazoles are a class of heterocyclic compounds with a bicyclic ring structure composed of a pyrazole ring and a benzene ring. Indazole-containing compounds with various functional groups have important pharmacological activities and can be used as structural motifs in designing novel drug molecules. Some of the indazole-containing molecules are approved by FDA and are already in the market. However, very few drugs with indazole rings have been developed against cardiovascular diseases. This review aims to summarize the structural and pharmacological functions of indazole derivatives which have shown efficacy against cardiovascular pathologies in experimental settings.

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Bicyclic Systems with Two Bridgehead (Ring Junction) Nitrogen Atoms

Cited by 3 publications

References 346 publications

Förster resonance energy transfer within single chain nanoparticles

Förster resonance energy transfer within single chain nanoparticles

Synthesis of Chiral Diazabicycloalkanes via Organocatalytic aza‐Michael/Aldol Reaction

Indazole and its Derivatives in Cardiovascular Diseases: Overview, Current Scenario, and Future Perspectives

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