“…In this regard, peptide ligands mimicing the interacting motif with the conserved key interacting residues show potentials to target these intracellular targets. Peptides constraint with suitable methods were shown to have improved biophysical properties, including enhanced protease resistance, cell‐penetration, and/or target binding affinity . Many chemical methods have been developed to constrain peptides into helical conformation by attaching different tethers to the peptide side chains, including disulfide/thioether bond formation, ring‐closing metathesis, lactam ring formation, “click” chemistry, addition of perfluoroarenes, vinyl‐sulfide formation, and so on.…”