Bicyclic lactones from the octocoral Dendronephthya mucronata

Abstract

The MeOH extract of the Vietnamese octocoral Dendronephthya mucronata afforded four bicyclic lactones (1−4), including three new compounds namely dendronephthyones A−C (1−3), after subjecting it on various chromatographic separations. The structures of the isolated compounds were established by spectroscopic experiments including 1D, 2D NMR, CD and HR-QTOF-MS. In addition, compounds 1−4 were found to exhibit selective cytotoxicity against the HeLa human cancer cell line

Novel Marine Secondary Metabolites Worthy of Development as Anticancer Agents: A Review

“…From the bioassay screening, Cpds. 565 – 567 exhibited weak selective cytotoxic activity against the HeLa human malignant tumor cell line with IC 50 values of 32.48, 30.12, 35.14, and 14.45 µM ( Table S5 ), respectively, but not against A-549 and Panc-1 (IC 50 > 100 µM) [ 96 ].…”

Marine natural products

“…S 8 was isolated from a Taiwanese collection of Sinularia humilis and the structure confirmed by XRD. 526 A number of simple lipids and quinonoid MNPs were reported from cnidarians including dendronephthyones A–C 1171–1173 isolated from a Vietnamese collection of Dendronephthya mucronata , 527 a simple epoxy-derivative of flexibilisquinone 1174 from southern Taiwan specimens of Sinularia scabra , 528 the related hydroquinone sarcotenuhydroquinone 1175 from Sarcophyton tenuispiculatum (cultured specimens), 529 and a series of terpenoid amide derivatives of spermidine and spermine sinularamide A–G 1176 , 1177 , 1178 and 1179–1182 isolated from Sinularia sp. 530 Sinularamide C exhibited weak inhibition of casitas B-lineage lymphoma proto-oncogene B with a potential role of enhancing the adaptive and innate immune system with implications for antitumour immunotherapies.…”

Natural Products from Octocorals of the Genus Dendronephthya (Family Nephtheidae)

“…Structures of lactones 83-86 were established by spectroscopic methods and these four compounds exhibited cytotoxicity toward HeLa (human papillomavirus-related endocervical adenocarcinoma) cells with IC 50 values of 32.48, 30.12, 35.45, and 14.45 µM, respectively [82]. Molecules 2020, 25, x FOR PEER REVIEW 9 of Structures of 5α-pregn-20-en-3,6-dione (77), 5α-pregn-20-en-3β-ol (78), 1,4,20-pregnatrien-3-one (79), 15β-acetoxypregna-1,4,20-trien-3-one (80), 5α-cholestan-3,6-dione (81), and 5αcholest-22-en-3,6-dione (82).Furthermore, three new bicyclo lactones, dendronephthyones A-C (83-85), along with a known analogue, suberosanone B (86)[81] (Figure 13), were isolated from the methanol extract of the same target material D. mucronata[82]. Structures of lactones 83-86 were established by spectroscopic methods and these four compounds exhibited cytotoxicity toward HeLa (human papillomavirusrelated endocervical adenocarcinoma) cells with IC50 values of 32.48, 30.12, 35.45, and 14.45 µ M, respectively[82].…”