Bicyclic 5-6 Systems with One Bridgehead (Ring Junction) Nitrogen Atom: Three Extra Heteroatoms 2:1

Hajós, György; Riedl, Zsuzsanna

doi:10.1016/b978-008044992-0.01016-6

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Cited by 5 publications

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“…In addition, this class of compounds has also been of great importance in the field of agriculture due to their remarkable activities as herbicides [19]. Consequently, TPs have inspired excellent reviews in the literature over the years on their chemistry and synthetic methods [20][21][22][23][24].…”

Section: Introductionmentioning

confidence: 99%

Three Component One-Pot Synthesis and Antiproliferative Activity of New [1,2,4]Triazolo[4,3-a]pyrimidines

et al. 2023

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A series of new [1,2,4]triazolo[4,3-a]pyrimidine derivatives was prepared using a one-pot three-component synthesis from 5-amino-1-phenyl-1H-1,2,4-triazoles, aromatic aldehydes and ethyl acetoacetate. The compound structures were confirmed by IR, 1H-NMR, 13C-NMR, HRMS and X-ray analyses. The biological activity of these compounds as antitumor agents was evaluated. Their antitumor activities against cancer cell lines (MDA-MB-231 and MCF-7) were tested by the MTT in vitro method. Among them, compounds 4c and 4j displayed the best antitumor activity with IC50 values of 17.83 μM and 19.73 μM against MDA-MB-231 and MCF-7 cell lines, respectively, compared to the Cisplatin reference.

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