Bicyclic 5-5 Systems with One Bridgehead (Ring Junction) Nitrogen Atom: Three Extra Heteroatoms 2:1

Cobalt‐Catalyzed Aerobic Oxidative Cyclization of 2‐Aminoanilines with Isonitriles: Facile Access to 2‐Aminobenzimidazoles

“…These compounds are convenient precursors to access a variety of differently substituted benzimidazoles for use as synthetic intermediates or final targets. For example, the treatment with triphenylphosphine dibromide generates iminophosphoranes (Scheme a), while treatment with aryl sulfonyl chlorides (Scheme b) or oximes (Scheme c) allow access to unique fused heterocyclic structures. Finally, others have shown this compound to be an intermediate in the synthesis of biologically active structures such as mebendazole (Scheme d) and enviroxime (Scheme e)…”

Synthesis of novel series of 3,5-disubstituted imidazo[1,2-d] [1,2,4]thiadiazoles involving SNAr and Suzuki–Miyaura cross-coupling reactions

“…For the past few decades, sulfur-containing [5,5] fused ring systems with a bridgehead nitrogen have received considerable attention in the drug discovery field due to their interesting biological activities. 1–6 For example, structures containing them have been reported in various therapeutic anticancer 7–9 and antitubercular 10 agents, and for cardiovascular treatments. 11 Moreover, other representative molecules have demonstrated their potential in the treatment of neurodegenerative disorders.…”

Facile green synthesis and potent antimicrobial efficacy of β-aminoheteronapthol via tailored Betti’s protocol and their bis-aryl hydrazone click products

“…The formation kinetics of the bis-aryl hydrazone bond are 20 to 900 times higher than those of conventional hydrazone/oxime bonds between alkyl aldehydes/ ketones and alkyl hydrazide or aminoxy probes. 14 The hydrazide hydrazones have been demonstrated to possess antibacterial, [15][16][17] anticonvulsant [18][19][20] and antitubercular 21 activities. Furthermore, the benefits of click reactions are well-known, and their applications have revolutionized numerous fields including bioconjugate chemistry, material chemistry and polymer sciences.…”