Bicyclic 1,2‐Diazepines

Synthesis and Characterization of Some New Benzodiazepinium Salt Derivatives under microwave Irradiation

“…It was later observed that the benzoimidazole formation via a condensation reaction was not happened. The scheme 2 shows the proposed reaction mechanism for the formation of the benzodiazepine salt (1)(2)(3)(4)(5)(6)(7)(8)(9)(10)(11)(12).It is proposed that the initial step is attack of the carbonyl carbon of acetone by the loin pair of electrons on the amino group. Due to the difference in electronegativity between the carbon atom and the oxygen atom of the carbonyl group, the electron density is than the carbon, making the oxygen acquire a partial negative charge and the carbon atom a partial positive charge.…”

“…The compounds of 1,5diazepinium salt derivatives (1)(2)(3)(4)(5)(6)(7)(8)(9)(10)(11)(12) have been synthesized with a good yield. An unexpected reaction was happened based on the reaction of 0phenylenediamine and benzoic acid derivatives in the presence of acetone and ethanol under microwave irradiation without a catalyst .…”

“…Diazepines and benzodiazepines have various therapeutic applications. Many members of the diazepine family are widely used as anticonvulsants, antianxiolitics, analgesics, sedatives, antidepressives and hypnotic agents [8][9][10][11]. Benzodiazepine derivatives are used as dyes for acrylic fibers [12].…”

Synthesis of Substituted 1,4-Diazepines and 1,5-Benzodiazepines Using an Efficient Heteropolyacid-Catalyzed Procedure

“…Diazepines and benzodiazepines have various therapeutic applications. Many members of the diazepine family are widely used as anticonvulsants, antianxiolitics, analgesics, sedatives, antidepressives and hypnotic agents [ 1 , 2 , 3 , 4 ]. Benzodiazepine derivatives are used as dyes for acrylic fibers [ 5 ].…”

CuI nanoparticles as a remarkable catalyst in the synthesis of benzo[b][1,5]diazepines: an eco-friendly approach

“…[1][2][3][4] In addition, some of the benzodiazepines have found as important drugs to treat some diseases such as cardiovascular disorders, cancer, diabetes and viral infection (HIV). [5][6][7][8] Some of the important 1,5-benzodiazepine structures with high medicinal activity such as, olanzapine 1 and clozapine 2 (schizophrenia treatment), 9 clobazam 3 (anxiolytic agents), 10 and 3-carbamoyl-1,5-benzodiazepine 4 (selective CCK-B antagonists as potential anxiolyticdrugs) 11 has been shown in Figure 1.…”