Bicontinuous cubic liquid crystals as sustained delivery systems for peptides and proteins

Rizwan, Shakila B.; Boyd, Ben J.; Rades, Thomas; Hook, Sarah

doi:10.1517/17425247.2010.515584

Cited by 115 publications

(89 citation statements)

References 75 publications

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“…It does not contain an ester functional group but consists of highly branched phytanyl tail with a tri-hydroxy headgroup. Both of DU and PT form cubic phases in presence of excess water which is also the case for the cores of stabilized lipid particles 13,45 ). 2.…”

Section: Preparation Of Lipid/water Bulk Phasesmentioning

confidence: 88%

“…The control over the particle size and biocompatibility is of utmost importance in order to optimize the therapeutic efficacy and hence the applicability of nanoparticles 7,8 . Lipids [9][10][11][12][13] , polymers 14,15 , metals 16,17 and carbon nanotubes 18,19 have been commonly employed as nanocarriers for various biomedical and pharmaceutical applications.…”

Section: Introductionmentioning

confidence: 99%

“…Lipids are integral constituents of cellular organelles as well as some food materials, therefore their decoration should ideally decrease the in vivo toxicity of CNTs. Biomedical applications based independently on CNTs 18,19 and lipid nanostructures [9][10][11][12][13] are under extensive development but the applications that combine properties of the two are not yet well-explored.…”

Section: Introductionmentioning

confidence: 99%

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Facile Preparation of Internally Self-assembled Lipid Particles Stabilized by Carbon Nanotubes

Patil-Sen

Sadeghpour

Rappolt

et al. 2016

JoVE

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We present a facile method to prepare nanostructured lipid particles stabilized by carbon nanotubes (CNTs). Single-walled (pristine) and multiwalled (functionalized) CNTs are used as stabilizers to produce Pickering type oil-in-water (O/W) emulsions. Lipids namely, Dimodan U and Phytantriol are used as emulsifiers, which in excess water self-assemble into the bicontinuous cubic Pn3m phase. This highly viscous phase is fragmented into smaller particles using a probe ultrasonicator in presence of conventional surfactant stabilizers or CNTs as done here. Initially, the CNTs (powder form) are dispersed in water followed by further ultrasonication with the molten lipid to form the final emulsion. During this process the CNTs get coated with lipid molecules, which in turn are presumed to surround the lipid droplets to form a particulate emulsion that is stable for months. The average size of CNT-stabilized nanostructured lipid particles is in the submicron range, which compares well with the particles stabilized using conventional surfactants. Small angle X-ray scattering data confirms the retention of the original Pn3m cubic phase in the CNT-stabilized lipid dispersions as compared to the pure lipid phase (bulk state). Blue shift and lowering of the intensities in characteristic G and G' bands of CNTs observed in Raman spectroscopy characterize the interaction between CNT surface and lipid molecules. These results suggest that the interactions between the CNTs and lipids are responsible for their mutual stabilization in aqueous solutions. As the concentrations of CNTs employed for stabilization are very low and lipid molecules are able to functionalize the CNTs, the toxicity of CNTs is expected to be insignificant while their biocompatibility is greatly enhanced. Hence the present approach finds a great potential in various biomedical applications, for instance, for developing hybrid nanocarrier systems for the delivery of multiple functional molecules as in combination therapy or polytherapy. Video LinkThe video component of this article can be found at

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Section: Preparation Of Lipid/water Bulk Phasesmentioning

confidence: 88%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Facile Preparation of Internally Self-assembled Lipid Particles Stabilized by Carbon Nanotubes

Patil-Sen

Sadeghpour

Rappolt

et al. 2016

JoVE

View full text Add to dashboard Cite

show abstract

“…2,3 Within the food and pharmaceutical research, LLC nano materials have shown potentials in the development of novel delivery systems. [4][5][6] These nanostructures are self-assemblies of naturally occurring surfactantlike lipid molecules which are closely related to those observed in biological membranes and empower the formation of efficient delivery matrices due to their impressive characteristics:…”

Section: Introductionmentioning

confidence: 99%

Lyotropic Liquid Crystalline Phases for the Formulation of Future Functional Foods

Sadeghpour¹

2016

JNHFE

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The especial features and advanced characteristics of Lyotropic Liquid Crystalline (LLC) phases as potent nano materials for encapsulation and the development of novel delivery systems for nutraceuticals and other bioactive compounds are reviewed. Exemplary, a focus is set on the health benefits of flavonoids and their current restrictions in bioavailability. Accordingly, our visions for application of LLC phases in the engineering of enhanced flavonoid-based food supplements and correlated challenges to overcome are highlighted.

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“…29,30 Major application of internally self-assembled lipid particles is for 'drug delivery' because of the possibility of loading them with hydrophilic, hydrophobic and amphiphilic molecules. [31][32][33] In this work we exploit CNTs as novel stabilizers for nanostructured lipid particles as depicted in Fig. 1.…”

Section: Introductionmentioning

confidence: 99%

Carbon nanotubes for stabilization of nanostructured lipid particles

et al. 2015

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Carbon nanotubes (CNTs) are increasingly studied for innovative biotechnological applications particularly where they are combined with essential biological materials like lipids. Lipids have been used earlier for enhancing the dispersibility of CNTs in aqueous solutions. Here we report a novel application of CNTs for stabilization of internally self-assembled nanostructured lipid particles of 2-5 μm size. Single-walled ( pristine) as well as -OH and -COOH functionalized multi-walled CNTs were employed to produce nanostructured emulsions which stayed stable for months and could be re-dispersed after complete dehydration. Concentrations of CNTs employed for stabilization were very low; moreover CNTs were well-decorated with lipid molecules. These features contribute towards reducing their toxicity and improving biocompatibility for biomedical and pharmaceutical applications. Our approach paves the way for future development of combination therapies employing both CNTs and nanostructured lipid self-assembly together as carriers of different drugs.

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Bicontinuous cubic liquid crystals as sustained delivery systems for peptides and proteins

Abstract: The bicontinuous cubic phase offers great potential in the field of peptide and protein delivery, but limited research in this area precludes definite conclusions to its future in this respect.

Cited by 115 publications

References 75 publications

Facile Preparation of Internally Self-assembled Lipid Particles Stabilized by Carbon Nanotubes

Facile Preparation of Internally Self-assembled Lipid Particles Stabilized by Carbon Nanotubes

Lyotropic Liquid Crystalline Phases for the Formulation of Future Functional Foods

Carbon nanotubes for stabilization of nanostructured lipid particles

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