Bicompatible porous Co3O4 nanoplates with intrinsic tumor metastasis inhibition for multimodal imaging and DNA damage–mediated tumor synergetic photothermal/photodynamic therapy

Yuan, Miaomiao; Xu, Shen; Zhang, Qianbing; Zhao, Bingxia; Feng, Bin; Ji, Kaiyuan; Yu, Lili; Chen, Wancheng; Hou, Meirong; Xu, Yang; Fu, Xuemei

doi:10.1016/j.cej.2020.124874

Cited by 26 publications

(20 citation statements)

References 42 publications

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“…Inspired by these interesting findings, we sought to develop novel QDs combined with non-noble metal-based nanomaterial which may bring PTT and PDT synergistic effects in one nano-system. For example, Co-based nanomaterial is well-studied non-noble metal-based nanomaterial, which is known for used as PTT agents for tumor therapy or imaging [ 36 ]. Therefore, we suggested that designing Co-based QDs may bring enhanced PTT/PDT synergistic effects.…”

Section: Introductionmentioning

confidence: 99%

CoFe2O4-Quantum Dots for Synergistic Photothermal/Photodynamic Therapy of Non-small-Cell Lung Cancer Via Triggering Apoptosis by Regulating PI3K/AKT Pathway

Liu

Shi²,

Zhang

et al. 2021

Nanoscale Res Lett

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Non-small-cell lung cancer (NSCLC) has become the second most diagnosed malignant tumors worldwide. As our long-term interests in seeking nanomaterials to develop strategies of cancer therapies, we herein constructed novel CoFe2O4-quantum dots (QDs) with outstanding synergistic photothermal/photodynamic property which suppressed NSCLC efficiently without apparent toxicity. We showed that the combination of CoFe2O4-QDs + NIR treatment induces apoptosis of NSCLC cells. In addition, the CoFe2O4-QDs + NIR treatment also promotes reactive oxygen species generation to trigger cell death through regulating PI3K/AKT pathway. Moreover, the CoFe2O4-QDs + NIR treatment successfully eliminates tumor xenografts in vivo without apparent toxic effects. Taken together, we reported that the novel nanomaterials CoFe2O4-QDs could exhibit enhanced synergistic photothermal therapy and photodynamic therapy effect on killing NSCLC without toxicity, which could be a promising photosensitizer for NSCLC therapy.

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Section: Introductionmentioning

confidence: 99%

CoFe2O4-Quantum Dots for Synergistic Photothermal/Photodynamic Therapy of Non-small-Cell Lung Cancer Via Triggering Apoptosis by Regulating PI3K/AKT Pathway

Liu

Shi²,

Zhang

et al. 2021

Nanoscale Res Lett

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“…Because of the unique properties of Co 3 O 4 NPs, their PTT/PDT and other functions are in ongoing examinations in many laboratories worldwide. In particular, Yuan et al [246] reported multifunctional abilities of pCo 3 O 4 NPs as photoacoustic/magnetic resonance contrast-imaging agents and as NIR-triggered PTT/PDT therapeutic nanoformulations. Furthermore, they also confirmed the suppression of the epithelial-mesenchymal transition (EMT) pathway by pCo 3 O 4 NPs.…”

Section: Combining Ppt With Other Therapies To Achieve Synergic Effic...mentioning

confidence: 99%

Photothermal and Photodynamic Therapy of Tumors with Plasmonic Nanoparticles: Challenges and Prospects

Bucharskaya

Khlebtsov

et al. 2022

Materials

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Cancer remains one of the leading causes of death in the world. For a number of neoplasms, the efficiency of conventional chemo- and radiation therapies is insufficient because of drug resistance and marked toxicity. Plasmonic photothermal therapy (PPT) using local hyperthermia induced by gold nanoparticles (AuNPs) has recently been extensively explored in tumor treatment. However, despite attractive promises, the current PPT status is limited by laboratory experiments, academic papers, and only a few preclinical studies. Unfortunately, most nanoformulations still share a similar fate: great laboratory promises and fair preclinical trials. This review discusses the current challenges and prospects of plasmonic nanomedicine based on PPT and photodynamic therapy (PDT). We start with consideration of the fundamental principles underlying plasmonic properties of AuNPs to tune their plasmon resonance for the desired NIR-I, NIR-2, and SWIR optical windows. The basic principles for simulation of optical cross-sections and plasmonic heating under CW and pulsed irradiation are discussed. Then, we consider the state-of-the-art methods for wet chemical synthesis of the most popular PPPT AuNPs such as silica/gold nanoshells, Au nanostars, nanorods, and nanocages. The photothermal efficiencies of these nanoparticles are compared, and their applications to current nanomedicine are shortly discussed. In a separate section, we discuss the fabrication of gold and other nanoparticles by the pulsed laser ablation in liquid method. The second part of the review is devoted to our recent experimental results on laser-activated interaction of AuNPs with tumor and healthy tissues and current achievements of other research groups in this application area. The unresolved issues of PPT are the significant accumulation of AuNPs in the organs of the mononuclear phagocyte system, causing potential toxic effects of nanoparticles, and the possibility of tumor recurrence due to the presence of survived tumor cells. The prospective ways of solving these problems are discussed, including developing combined antitumor therapy based on combined PPT and PDT. In the conclusion section, we summarize the most urgent needs of current PPT-based nanomedicine.

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“…Moreover, pCo 3 O 4 NPs exhibited broad near‐infrared (NIR) laser absorbance, high photothermal conversion efficiency, distinguished colloidal stability, excellent biocompatibility and promising multifunctional groups. Overall, pCo 3 O 4 NPs represent a promising phototheranostics agent for multimodal imaging (photoacoustic/magnetic resonance imaging) and PTT/PDT synergistic phototherapy of tumors (67).…”

Section: Cobaltmentioning

confidence: 99%

Photodynamic Therapy of Inorganic Complexes for the Treatment of Cancer^†

Smith

Days

Alajroush

et al. 2021

Photochem & Photobiology

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Photodynamic therapy (PDT) is a medicinal tool that uses a photosensitizer and a light source to treat several conditions, including cancer. PDT uses reactive oxygen species such as cytotoxic singlet oxygen (1O2) to induce cell death in cancer cells. Chemotherapy has historically utilized the cytotoxic effects of many metals, especially transition metal complexes. However, chemotherapy is a systemic treatment so all cells in a patient’s body are exposed to the same cytotoxic effects. Transition metal complexes have also shown high cytotoxicity as PDT agents. PDT is a potential localized method for treating several cancer types by using inorganic complexes as photosensitizing agents. This review covers several in vitro and in vivo studies, as well as clinical trials that reported on the anticancer properties of inorganic pharmaceuticals used in PDT against different types of cancer.

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Bicompatible porous Co3O4 nanoplates with intrinsic tumor metastasis inhibition for multimodal imaging and DNA damage–mediated tumor synergetic photothermal/photodynamic therapy

Cited by 26 publications

References 42 publications

CoFe2O4-Quantum Dots for Synergistic Photothermal/Photodynamic Therapy of Non-small-Cell Lung Cancer Via Triggering Apoptosis by Regulating PI3K/AKT Pathway

CoFe2O4-Quantum Dots for Synergistic Photothermal/Photodynamic Therapy of Non-small-Cell Lung Cancer Via Triggering Apoptosis by Regulating PI3K/AKT Pathway

Photothermal and Photodynamic Therapy of Tumors with Plasmonic Nanoparticles: Challenges and Prospects

Photodynamic Therapy of Inorganic Complexes for the Treatment of Cancer^†

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Bicompatible porous Co3O4 nanoplates with intrinsic tumor metastasis inhibition for multimodal imaging and DNA damage–mediated tumor synergetic photothermal/photodynamic therapy

Cited by 26 publications

References 42 publications

CoFe2O4-Quantum Dots for Synergistic Photothermal/Photodynamic Therapy of Non-small-Cell Lung Cancer Via Triggering Apoptosis by Regulating PI3K/AKT Pathway

CoFe2O4-Quantum Dots for Synergistic Photothermal/Photodynamic Therapy of Non-small-Cell Lung Cancer Via Triggering Apoptosis by Regulating PI3K/AKT Pathway

Photothermal and Photodynamic Therapy of Tumors with Plasmonic Nanoparticles: Challenges and Prospects

Photodynamic Therapy of Inorganic Complexes for the Treatment of Cancer†

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Product

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Photodynamic Therapy of Inorganic Complexes for the Treatment of Cancer^†