Bicluster and Pathway Enrichment Analysis of HCV-induced Cirrhosis and Hepatocellular Carcinoma

Peng, Cheng; Cheng, You; Su, Mei X; Li, Dong; Zhao, Guoming; Gao, Hui; Li, Yan; Zhu, Jie; Li, Hua; Zhang, Tao

doi:10.7314/apjcp.2012.13.8.3741

Cited by 16 publications

(9 citation statements)

References 38 publications

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“…HCV infection is well known globally as one of the main risk factor in HCC development even if evidence for its causal role in hepatocarcinogenesis is a little more recent [ 33 , 34 ]. The rate of HCC progression varies greatly among patients with chronic HCV infection and this is probably due to the existence of a complex interplay between host, viral and environmental factors [ 35 ], including older age, male gender, alcohol intake and HCV infection [ 36 - 38 ].…”

Section: Chronic Hcv Infectionmentioning

confidence: 99%

Epidemiology of Hepatitis B Virus (HBV) and Hepatitis C Virus (HCV) Related Hepatocellular Carcinoma

Petruzziello

2018

TOVJ

193

155

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Introduction:Hepatocellular carcinoma (HCC) is one of the most prevalent primary malignant tumors and accounts for about 90% of all primary liver cancers. Its distribution varies greatly according to geographic location and it is more common in middle and low- income countries than in developed ones especially in Eastern Asia and Sub Saharan Africa (70% of all new HCCs worldwide), with incidence rates of over 20 per 100,000 individuals.Explanation:The most important risk factors for HCC are Hepatitis B Virus (HBV) infection, Hepatitis C Virus (HCV) infection, excessive consumption of alcohol and exposition to aflatoxin B1. Its geographic variability and heterogeneity have been widely associated with the different distribution of HBV and HCV infections worldwide.Chronic HBV infection is one of the leading risk factors for HCC globally accounting for at least 50% cases of primary liver tumors worldwide. Generally, while HBV is the main causative agent in the high incidence HCC areas, HCV is the major etiological factor in low incidence HCC areas, like Western Europe and North America.Conclusion:HBV-induced HCC is a complex, stepwise process that includes integration of HBV DNA into host DNA at multiple or single sites. On the contrary, the cancerogenesis mechanism of HCV is not completely known and it still remains controversial as to whether HCV itself plays a direct role in the development of tumorigenic progression.

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Section: Chronic Hcv Infectionmentioning

confidence: 99%

Epidemiology of Hepatitis B Virus (HBV) and Hepatitis C Virus (HCV) Related Hepatocellular Carcinoma

Petruzziello

2018

TOVJ

193

155

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“…Alcohol drinking was responsible for 15.7% with smoking responsible for 13.9% (Fan et al, 2013). The differentially expressed genes study between cirrhosis and HCC samples showed the upregulating of ECM-receptor interaction, focal adhesion, cell adhesion molecules and other cancer-related pathways, and downregulating of complement and coagulation cascades pathways involved in HCV-induced hepatocarcinogenesis (Cheng, et al, 2012). They also found a significant hypermethylation of tumor suppressor genes (P14, P15, and P73), and a mismatch repair gene (O6MGMT) in HCV related chronic liver disease and HCC.…”

Section: Introductionmentioning

confidence: 99%

Epidemiology of Hepatitis C Virus Genotypes in Northeastern Thai Blood Samples

Barusrux

Sengthong²,

Urwijitaroon³

2014

Asian Pacific Journal of Cancer Prevention

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Background: Hepatitis C virus (HCV) infection is an important cause of liver cancer in Thailand. The highest prevalence of anti-HCV positive among Thai blood donors is found in the northeastern region. The present analysis of the genotype distribution among anti-HCV positive northeastern-Thai blood donors was conducted to provide a base for the epidemiological pattern of HCV infection in this region. Materials and Methods: A total of 112 HCV seropositive healthy blood donors were randomly selected and tested for the presence of HCV-RNA by RT-PCR. HCV-RNA positive samples were genotyped by direct sequencing at core region genomes and confirmed by phylogenetic analysis. Results: HCV viremia was found in 94.6% (106/112) of HCV seropositive blood donors. There were 3 major genotypes distributed among this population. HCV genotype 3a was the most prevalent (71.7%) followed by genotypes 1a (7.5%), 1b (7.5%), 6i (3.8%), 6f (2.8%) and 6n (1.9%). Conclusions: HCV genotype 3a in asymptomatic infections in northeastern Thailand is significantly higher than other previous reports. Subgenotype 6 prevalence is less than in neighboring countries and distribution patterns differ. The findings are relevant as predictors for using interferon therapy in this population.

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“…Thus, with a population of more than 80 million, Egypt is considered to have the highest prevalence of hepatitis C in the world and consequently a high frequency of hepatocellular carcinoma (HCC) (Zekri et al, 2012;2013). It was shown that, approximately 30% of infected individuals clear the viral infection naturally while 70% develop chronic disease that may finally lead to liver cirrhosis (LC) and/or hepatocellular carcinoma (HCC) (Morgan, 2011;Cheng et al, 2012). Several immunological factors are implicated in the determination of disease outcome in HCV infected patients including the adaptive immune response and the innate immune system, which regulate disease progression in those patients (Rehermann, 2009;Zekri et al, 2010).…”

Section: Introductionmentioning

confidence: 99%

IL28B rs12979860 Gene Polymorphism in Egyptian Patients with Chronic Liver Disease Infected with HCV

Zekri¹,

Salama²,

Medhat³

et al. 2014

Asian Pacific Journal of Cancer Prevention

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Background: Egypt has one of the highest prevalences of hepatitis C virus (HCV) infection worldwide. Although the IL28B gene polymorphism has been shown to modify the course of chronic HCV infection, this has not been properly assessed in the Egyptian population. Materials and Methods: The IL28B rs12979860 single nucleotide polymorphism (SNP) was therefore examined in 256 HCV-infected Egyptian patients (group II) at different stages of disease progression and in 48 healthy volunteers (group I). Group II was subdivided into GII-A (chronic hepatitis patients, n=119), GII-B (post hepatitis cirrhosis, n=66) and GII-C (HCC on top of cirrhosis, n=71). Results: The C/T genotype was the commonest in all groups. It was more frequent in GI (52%) than in GII (48%). There was no significant difference in the frequency of C/T and C/C or T/T genotypes between groups and subgroups (p=0.82). Within the subgroups; the C/C genotype was more common in GII-B while C/T and T/T genotypes were more common in GII-C, though with no significant difference (p=0.59 and p=0.80). There was no significant association between IL28B rs12979860 SNP and viral load, ALT, AFP level, METAVIR scores for necro-inflammation and fibrosis, and Child-Pugh classification. Conclusions: 1) IL28Brs12979860 C/T genotype is the commonest genotype in HCV-associated CH and HCC in Egypt. 2) IL28Brs12979860 polymorphisms are not associated with disease progression or aggression (histological staging, severity of fibrosis in CH or the incidence of post-HCV HCC). 3) Differences in IL28Brs12979860 genotypes could be a consequence of environmental or ethnic variation.

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Bicluster and Pathway Enrichment Analysis of HCV-induced Cirrhosis and Hepatocellular Carcinoma

Cited by 16 publications

References 38 publications

Epidemiology of Hepatitis B Virus (HBV) and Hepatitis C Virus (HCV) Related Hepatocellular Carcinoma

Epidemiology of Hepatitis B Virus (HBV) and Hepatitis C Virus (HCV) Related Hepatocellular Carcinoma

Epidemiology of Hepatitis C Virus Genotypes in Northeastern Thai Blood Samples

IL28B rs12979860 Gene Polymorphism in Egyptian Patients with Chronic Liver Disease Infected with HCV

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