Bichromophoric ruthenium(ii) bis-terpyridine-BODIPY based photosensitizers for cellular imaging and photodynamic therapy

Abstract

Two multichromophoric homoleptic ruthenium(II) complexes [Ru(tpy-BODIPY)2]Cl2 (complexes 1 and 2, tpy = 4-phenyl-2,2:6,2-terpyridine, BODIPY = boron-dipyrromethene) were prepared, characterized and their phototherapeutic activity and bioimaging properties studied. The complexes having...

Bichromophoric BODIPY and Biotin Tagged Terpyridyl Ruthenium(II) Complexes for Cellular Imaging and Photodynamic Therapy

“…The lowest energy band in compound 3 receives a contribution from MLCT and BODIPY based π-π* transitions as observed in similar systems. [27] Overall, the λ max values obtained from TDDFT calculations agree well with the experimental values (Table S4).…”

“…A similar phenomenon is typical for Ru(II)-organic chromophore dyad systems. [27] This study highlights the potential of compound 3 in generating singlet oxygen in high yield on light exposure imparting selectivity in killing cancer cells while being innocuous to the unexposed healthy cells.…”

“…[24] To address this drawback, covalently bound BODIPY moiety to the {(tpy)-Ru(II)-(tpy)} unit was utilized by Ziessel, Sun, and us for light-driven applications. [25][26][27] In Sun's and our work, the two chromophores, namely, BODIPY and {Ru II (tpy) 2 } are connected via a phenyl ring spacer. One drawback of these systems is their low fluorescence, limiting their diagnostic imaging use.…”

A photo-degradable BODIPY-modified Ru(ii) photosensitizer for safe and efficient PDT under both normoxic and hypoxic conditions

“…2c), which is much longer than that of a typical Ru( ii )-based 3 MLCT (usually shorter than 1 μs) and can be ascribed to the BODIPY-based 3 ππ* state. 58,59 Based on these results, a simplified Jablonski diagram of complex 1 is shown in Fig. 2d.…”

Synthesis and Theoretical and Photophysical Study on a Series of Neutral Ruthenium(II) Complexes with Donor–Metal–Accepter Configuration

“…Ruthenium­(II) polypyridine complexes have long been the interest of researchers owing to their abundant properties related to optical physics, chemistry, and electrochemistry, which enable them to function well in fields of (i) energy conversion including dye-sensitized solar cells , and dye-sensitized photoelectrochemical cells (DS-PECs); (ii) luminescence including organic light-emitting diodes (OLEDs) , and light-emitting electrochemical cells; (iii) biomedical researches like detection, bioimaging, and anticancer; − (iv) catalyst for chemical reactions. − Bearing a strong chelating effect, ruthenium­(II) terpyridine complexes exhibit fine photostability and achiral configurations, which are suitable for constructing ordered multinuclear assembly architectures based on the specific design. Nevertheless, ruthenium­(II) terpyridine complexes have been suffering from low intrinsic quantum yields and short lifetime of excited states, caused by fast energy transfer from the emissive 3 MLCT state to the nonemissive triplet metal-centered 3 MC state, which arises from their distorted octahedral geometries due to the terpyridine related N–Ru–N trans angle of ca.…”