Bicarbonate-Buffered Peritoneal Dialysis

Lactate-Containing Peritoneal Dialysis Solutions

“…However, the superiority of the former PDS's in these areas appears to be less obvious when compared to lactate-containing PDS's with comparable pH's (Personal observations). Also, most bicarbonate-buffered PDS's have bicarbonate and PC0 2 values much higher than those of normal plasma (49). Whether these abnormally elevated levels are injurious to cells (e.g., a high PC0 2 level might cause intracellular respiratory acidosis) or not is at present largely unknown.…”

Lactate-Containing versus Bicarbonate -Containing Peritoneal Dialysis Solutions

“…In certain disease states, such as lactic acidosis (12) and liver failure (13), the metabo lism of lactate may be deficient. The use of conventional PDS's in such circumstances not only may fail to raise serum bicarbonate levels through the me tabolism of lactate, but also may actually lead to the lowering of serum bicarbonate concentrations through removal by dialysis (14).…”

“…Because of the aforementioned difficulties and because of the fact that bicarbonate is a physiologic buffer, various investigators have pursued the use of bicarbonate as a buffer base in the formulation of PDS's (1,14,(16)(17)(18).…”