Bibliometric study of neuroinflammation in autism spectrum disorder

Abstract

BackgroundNeuroinflammation is closely associated with the occurrence and development of autism spectrum disorder (ASD). This study aims to describe the global development history and current status of neuroinflammation in ASD from 2004 to 2021 and reveal the research hotspots and frontiers to provide a reference for scholars in related fields to carry out further research.MethodsJournal articles on ASD and neuroinflammation-related research were obtained from the Web of Science Core Collection (WOSCC) database from its inception to 2021. Literature was analyzed visually by VOSviewer, CiteSpace, and R language, including publication analysis, author, institution, national/regional cooperative network analysis, and keyword analysis. We screened the most accumulatively cited 10 experimental papers in the field and the most cited 10 experimental papers in the last 2 years (2020 and 2021) for combing.ResultsA total of 620 publications were included in this study, and the number of publications has increased in recent years. The United States (256, 41.29%) was the country with the largest number of publications. King Saud University (40, 6.45%) was the most published institution; Laila Al-Ayadhi Yousef was the most published researcher; the Brain Behavior and Immunity was the main journal for the study of neuroinflammation in autism, having published 22 related articles. Keyword co-occurrence analysis showed that short chain fatty acid, mast cells, and glial cells have been the focus of recent attention. Burst keywords show that gut microbiota and immune system are the future research trends.ConclusionThis bibliometric study describes the basic framework for the development in the field of neuroinflammation and ASD through an exploration of key indicators (countries, institutions, journals, authors, and keywords). We found that the key role of neuroinflammation in the development of ASD is attracting more and more researchers’ attention. Future studies can investigate the changes in cytokines and glial cells and their related pathways in ASD neuroinflammation. Immunotherapy to inhibit neuroinflammation may be intensively studied as a direction for ASD treatment or intervention.

Forensic Age Estimation: A Bibliometric Analysis of Research Studies in Web of Science Database

“…Bibliyometrik analiz çalışmaları, bilimsel yayınların nicelik ve nitelik özelliklerini inceleyerek araştırma trendlerini ve bilimsel etkileşimi anlamamızı sağlayan, ayrıca bilim dünyasındaki gelişmeleri anlamak, araştırma alanlarını belirlemek ve gelecekteki çalışmalara yön vermek için değerli bilgiler sunan önemli bir çalışma türüdür. Son yıllarda yapılan araştırmalar, bibliyometrik analizin farklı disiplinlerde yaygın olarak kullanıldığını ve yeni yöntemlerin geliştirildiğini göstermekte, bilimsel yayınların sayısal verilerine dayanarak disiplinler arası etkileşimi, en çok atıfta bulunan yayınları ve popüler araştırma konularını belirlememize yardımcı olmaktadır (6)(7)(8)(9). Bu çalışmanın amacı, son yıllarda artan trendi ile göze çarpan yaş tahmini konusunda yapılan bilimsel araştırmalar arasından ISI Web of Knowledge-Science (WoS),Clarivate™, Philadelphia, PA, USA veritabanında yer alan eserlere ulaşmak, burada yer alan filtreleme yöntemlerini kullanarak eserlerin bibliometrik analizini yapmaktır.…”

Shorter telomere length in children with autism spectrum disorder is associated with oxidative stress

“…In recent years, studies have found that the increase of intracellular reactive oxygen species (ROS) and reduced free radical damage can easily lead to a reduction in endogenous antioxidant protection system capacity and an oxidative stress (OS) imbalance. This will promote the secretion of vascular and pro-inflammatory molecules and lead to neuroinflammation (3). These oxidative damage processes exist in a wide range of mental diseases.…”