Bibliometric and visual analysis of research on the links between the gut microbiota and pain from 2002 to 2021

Abstract

Background and aimsThe gut microbiota is involved in the regulation of pain, which is proved by plenty of evidence. Although a substantial quantity of research on the link between the gut microbiota and pain has emerged, no study has focused on the bibliometric analysis of this topic. We aim to present a bibliometric review of publications over the past 20 years and predict research hot spots.MethodsRelevant publications between 2002 and 2021 were extracted from the Science Citation Index-Expanded (SCI-EXPANDED) of the Web of Science Core Collection (WoSCC) database on April 22, 2022. CiteSpace (version 5.8 R3c), VOSviewer, the Online Analysis Platform of Literature Metrology, and the R package bibliometrix were used to analyze and visualize.ResultsA total of 233 articles have been published between 2002 and 2021. The number of publication outputs increased rapidly since 2016. The collaboration network revealed that the USA, Baylor College of Medicine, and Vassilia Theodorou were the most influential country, institute, and scholar, respectively. Alimentary pharmacology and therapeutics and Gut were the most co-cited journal and Neurogastroenterology and Motility was the most productive journal. Visceral sensitivity, fibromyalgia, gastrointestinal, chronic pain, stress, gut microbiome, LGG, brain-gut axis, SLAB51, and sequencing were the top 10 clusters in co-occurrence cluster analysis. Keyword burst detection indicated that the brain-gut axis and short-chain fatty acid were the current research hot spots.ConclusionResearch on the links between the gut microbiota and pain has increased rapidly since 2016. The current research focused on the brain-gut axis and short-chain fatty acid. Accordingly, the SCFAs-mediated mechanism of pain regulation will be a research direction of great importance on the links between the gut microbiota and pain. This study provided instructive assistance to direct future research efforts on the links between the gut microbiota and pain.

Emerging trends and hotspots of the itch research: A bibliometric and visualized analysis

“…Older papers may often receive more citations, and many other factors influence citation rates, such as self‐citation. 62 We attempted to reduce the risk of such errors by conducting a rigorous review of included articles.…”

“…Finally, bibliometric analysis has a potential time effect bias. Older papers may often receive more citations, and many other factors influence citation rates, such as self-citation 62. We attempted to reduce the risk of such errors by conducting a rigorous review of included articles.5 | CON CLUS IONSIn conclusion, this is the first bibliometric and visual analysis of itch research.…”

Cartilage tissue healing and regeneration based on biocompatible materials: a systematic review and bibliometric analysis from 1993 to 2022

“…To provide a comprehensive analysis of the literature on the healing and regeneration of cartilage tissue using biocompatible materials, all relevant data meeting the inclusion criteria were further analyzed using two software programs: Bibliometrix (RStudio, V1.4) ( Aria and Cuccurullo, 2017 ) and CiteSpace V5.8 R3 (Drexel University, Philadelphia, PA, USA) ( Mao et al, 2022 ).…”

Emerging trends and hotspots in metabolic dysfunction-associated fatty liver disease (MAFLD) research from 2012 to 2021: A bibliometric analysis

“…Bibliometric analysis involves a timely and comprehensive review of publications during a specific period by analyzing their parameters such as the number of publications, authors, countries, and regions, references, keywords, etc. This approach provides a thorough overview of the intellectual landscape and helps researchers by highlighting the latest research trends (17)(18)(19). We aimed to analyze the publication trend of MAFLD from 2012 to 2021, to identify novel discoveries in pathogenesis and possible treatment measures, and to provide a panoramic overview of the research field for other researchers.…”