Bibliometric Analysis of the Toxicity of Bisphenol A

Abstract

Bisphenol A (BPA) is used worldwide and research on the toxicity of BPA has advanced rapidly in the last few decades. This study aimed to evaluate the global scientific output of toxicity of BPA and explore the hot spots and research trends. All available articles related to the toxicity of BPA until 2022 were retrieved from the Web of Science Core Collection database. The VOSviewer, a bibliometric analysis software, was used to analyze the information of included articles, including countries/institutions, international cooperation, journals, citations, and keywords. Among 1644 retrieved articles, 1611 eligible studies were identified for analysis, and the annual publications increased with time in the past three decades. China and the United States were the most active contributors in this field. Chinese Academy of Sciences and the Dow chemical company conducted relatively more research than others about BPA toxicity. The journal “Chemosphere” published the most studies on “BPA toxicity”. Before 2015, most research focused on estrogenic activity and the test system mainly utilized animal experiments. However, in recent years, research related to toxic mechanisms of BPA at the cellular level and the toxicity of its analogs have received widespread attention. Considering some critical research gaps, future research on BPA toxicology should probably focus on the molecular biology of toxic mechanism, mixture toxicity, and co-exposure of BPA substitutes. This study will help researchers understand past and current research trends, hot spots, and trends of toxicity studies of BPA and, thus, contribute to further research and risk management of BPA.

Bibliometric Analysis of Research on the Main Genes Involved in Meat Tenderness

“…Co-authorships are shown in Figure 2 by an overlay visualization network whose elements (authors, in this case) are labeled in colored circles and connected with lines. The higher the frequency (number of papers), the larger the circle and label; the colors of the circles distinguish the time at which the authors published their papers, and the distance between each element represents their correlation [ 31 ].…”

“…Regarding inter-country co-authorship, Figure 3 a shows a network visualization map; it is similar to the overlay visualization map, but in this case, colored circles distinguish between groups according to the relationship between countries [ 31 ]. The group made up of the United States, Brazil, Argentina, South Korea, Argentina and China stands out.…”

“…In addition, Scopus provides a data analysis tool to complement the bibliometric evaluation. To obtain more accurate and reliable results, the document search was performed by article title, abstract and keywords [ 31 ] with the following string: (“meat tenderness” AND gene). Only original articles in English were included to avoid duplicates, and only articles published up to 2021 were included to compare complete annual periods [ 32 ].…”

“…Scholars can use the results to evaluate the evolution of science, determine outdated and emerging methodologies, identify and explore a gap in the literature, solicit support from prolific authors in a field, conduct research in countries with little knowledge and production on the topic of study, select relevant papers (based on the number of citations) to start a new study, etc. Bibliometric analysis is quantitative, rigorous and objective, allowing for a systematic, transparent and reproducible study [ 30 ]; therefore, it is more efficient than a traditional literature review [ 31 ].…”

The Trends and Hotspots in Premature Ovarian Insufficiency Therapy from 2000 to 2022

“…The larger the number of items in the neighborhood of a point and the higher the weights of the neighboring items, the closer the color of the point is to yellow. Furthermore, in order to allow the results to be reproduced, we will indicate all the parameters used for building the maps [ 20 , 21 ].…”