Bibliometric Analysis of Dendritic Epidermal T Cell (DETC) Research From 1983 to 2019

Deng, Ziqin; Wang, Hongwei; Chen, Zhiye; Wang, Ting

doi:10.3389/fimmu.2020.00259

Cited by 58 publications

(59 citation statements)

References 84 publications

(91 reference statements)

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“…And finally, we conducted the search with the following formula, designed according to the search rules of Scopus (Deng et al, 2020 ): TITLE-ABS-KEY (“human coronavirus” OR “human corona virus” OR HCoV OR “novel coronavirus” OR “novel corona virus” OR nCoV OR “severe acute respiratory syndrome” OR ({SARS} AND “ * CoV” OR * virus OR crisis OR outbreak OR epidemic OR pandemic) OR “SARSr-CoV” OR “middle east respiratory syndrome” OR ({MERS} AND “ * CoV” OR * virus OR crisis OR outbreak OR epidemic OR pandemic) OR “camel flu” OR “EMC/2012” OR “coronavirus disease 2019” OR “COVID-19” OR (coronavirus OR “corona virus” OR “ * CoV” AND 229E OR OC43 OR NL63 OR HKU1) OR HCoV229E OR HCoVOC43 OR HCoVNL63 OR HCoVHKU1) ( Table 1 ).…”

Section: Methodsmentioning

confidence: 99%

“…This is particularly true in the current age, where thousands of reports can be easily exchanged between public health specialists and healthcare providers across the internet (Takahashi-Omoe and Omoe, 2012 ; Unkel et al, 2012 ). Bibliometrics is also recognized as an essential tool and is widely used in a variety of fields to measure and evaluate scientific research quantitatively and qualitatively (Aggarwal et al, 2016 ; Romero and Portillo-Salido, 2019 ; Deng et al, 2020 ). Therefore, in order to accurately, effectively and systematically reveal connections within the human coronavirus field, our study applied bibliometrics and visualization methods to analyze human coronaviruses-related publications and citations, countries and affiliations, as well as journal performance, author impact and keyword co-occurrence cluster.…”

Section: Introductionmentioning

confidence: 99%

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Bibliometric and Visualization Analysis of Human Coronaviruses: Prospects and Implications for COVID-19 Research

Deng

Chen

Wang

2020

Front. Cell. Infect. Microbiol.

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Human coronaviruses, which can cause a range of infectious diseases, have been studied for nearly 60 years. The field has gained renewed interest from researchers around the world due to the COVID-19 outbreak in late 2019. Despite a large amount of research, little is known about the knowledge structure and developing trends of this topic. Here, we apply bibliometric analysis along with visualization tools to analyze 15,207 publications related to human coronavirus from the Scopus database, using indicators on publication and citation, journal, country or territory, affiliation and international cooperation, author, and keyword co-occurrence cluster. The results show that research on human coronavirus is dominated by SARS-CoV. Although there have been many publications, only 626 publications (4.1% of total) have more than 100 citations. The top 20 journals with most publications account for 20.6% of total publications and 41% of total citations. In addition to the United States and some European countries, many Asian and African countries are involved in this research, with China holding an important position in this area. Leading researchers from various fields of human coronavirus research are listed to facilitate collaboration and promote effective disease prevention and control. The keywords co-occurrence analysis reveals that the research focus on virology, public health, drugs and other hotspot fields, and uncovers changes in the direction of coronavirus research. The research map on human coronavirus obtained by our analysis are expected to help researchers to efficiently and effectively explore COVID-19.

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Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Bibliometric and Visualization Analysis of Human Coronaviruses: Prospects and Implications for COVID-19 Research

Deng

Chen

Wang

2020

Front. Cell. Infect. Microbiol.

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“…To further determine whether the loss of Zdhhc2 will affect the functions of the three types of T cells, the transfer experiment was performed by intravenous injection of purified lymph node CD45.2 + T cells into CD45.1 + CD3ϵ −/− mice. However, previously studies showed that γδ T cells represent only 1~2% of all T cells in lymph nodes ( 26 ), and DETC are only restricted to the murine epidermis ( 27 ). Therefore, we mainly detected the absolute number of CD45.2 + total T cells and CD45.2 + αβ T cells in the inflamed skin ( Supplementary Figure 3A ).…”

Section: Resultsmentioning

confidence: 99%

Zdhhc2 Is Essential for Plasmacytoid Dendritic Cells Mediated Inflammatory Response in Psoriasis

Zhou

Yang

et al. 2021

Front. Immunol.

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Zdhhc family genes are composed of 24 members that regulate palmitoylation, a post-translational modification process for proteins. Mutations in genes that alter palmitoylation or de-palmitoylation could result in neurodegenerative diseases and inflammatory disorders. In this study, we found that Zdhhc2 was robustly induced in psoriatic skin and loss of Zdhhc2 in mice by CRISPR/Cas9 dramatically inhibited pathology of the ear skin following imiquimod treatment. As psoriasis is an inflammatory disorder, we analyzed tissue infiltrating immune cells and cytokine production. Strikingly we found that a master psoriatic cytokine interferon-α (IFN-α) in the lesioned skin of wildtype (WT) mice was 23-fold higher than that in Zdhhc2 deficient counterparts. In addition, we found that CD45+ white blood cells (WBC) infiltrating in the skin of Zdhhc2 deficient mice were also significantly reduced. Amelioration in psoriasis and dramatically reduced inflammation of Zdhhc2 deficient mice led us to analyze the cellular components that were affected by loss of Zdhhc2. We found that imiquimod induced plasmacytoid dendritic cell (pDC) accumulation in psoriatic skin, spleen, and draining lymph nodes (DLN) were drastically decreased in Zdhhc2 deficient mice, and the expression of pDC activation marker CD80 also exhibited significantly inhibited in psoriatic skin. In further experiments, we confirmed the cell intrinsic effect of Zdhhc2 on pDCs as we found that loss of zDHHC2 in human CAL-1 pDC dampened both interferon regulatory factor 7 (IRF7) phosphorylation and IFN-α production. Therefore, we identified novel function of Zdhhc2 in controlling inflammatory response in psoriasis in mice and we also confirmed that crucial role of Zdhhc2 in pDCs by regulating IRF7 activity and production of the critical cytokine. Our results finding the dependence of IFN-α production on Zdhhc2 in inflamed murine skin and in human pDCs provide rationale for targeting this new molecule in treatment of inflammation.

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“…Previous research revealed that BTN3A1 was required in the activation of human Vγ9Vδ2 T cells (15), and BTNL3 and BTNL8 were found to bind Vγ4 + TCR (16,17). In mice, Skint1, the new member of BTN family, was required for positive selection of Vγ5 + T cells in the embryonic thymus and contributed to normal levels of these dendritic epidermal T cells in skin, which play an important role in wound healing and preventing cancer (18,19). BTNL1 and BTNL6 jointly regulated intestinal Vγ7 γδ T-cell function in mice, and human gut epithelial cells expressed BTNL3 and BTNL8 and stimulated Vγ4 γδ T cells (17).…”

Section: Introductionmentioning

confidence: 99%

Bibliometrics Analysis of Butyrophilins as Immune Regulators [1992–2019] and Implications for Cancer Prognosis

et al. 2020

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The butyrophilins (BTNs) represent a unique family of immunoglobulin. They were considered to be involved in milk lactation after their discovery in 1981. With the development of research, an increasing number of research revealed that BTNs play important roles in immune regulation [1992-2019]. Our research aimed to summarize the BTN research status and their relationship with lung cancers and breast cancers by bibliometrics and bioinformatics methods. Our results indicate that the researches on immune-regulatory functions of BTNs gradually developed from 1992 to 2006, whereas they increased quickly after 2007. There are international cooperations among 56 countries, of which the United States is the most active one with the highest number of studies as well as highest citations. By coauthorship and cocitation analysis, we showed that Adrian Hayday, who is active in γδ T-cell field, was an active author in BTN publications with average year of 2015 and led a subfield. By keywords co-occurrence analysis, we found that γδ T cell, which is an important cancer immune regulator, is one important hotspot. Finally, we found that several BTN members' expression levels were significantly correlated with prognosis of lung cancer and breast cancer patients. Thus, these BTNs might play immune regulatory effects and could serve as potential biomarkers for cancer.

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Bibliometric Analysis of Dendritic Epidermal T Cell (DETC) Research From 1983 to 2019

Cited by 58 publications

References 84 publications

Bibliometric and Visualization Analysis of Human Coronaviruses: Prospects and Implications for COVID-19 Research

Bibliometric and Visualization Analysis of Human Coronaviruses: Prospects and Implications for COVID-19 Research

Zdhhc2 Is Essential for Plasmacytoid Dendritic Cells Mediated Inflammatory Response in Psoriasis

Bibliometrics Analysis of Butyrophilins as Immune Regulators [1992–2019] and Implications for Cancer Prognosis

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