Biased neurocognitive self-perception in depressive and in healthy persons

Schwert, Christine; Stohrer, Maren; Aschenbrenner, Steffen; Weisbrod, Matthias; Schröder, Annette

doi:10.1016/j.jad.2018.02.031

Cited by 41 publications

(24 citation statements)

References 24 publications

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“…39 Recent research in fact provides evidence for an underestimation of cognitive ability in people with depression and an overestimation of cognitive ability in healthy controls relative to their objective cognitive performance. 40 However, the discrepancy between subjective and objective cognitive functioning in individuals with depression may vary as a function of their age and depression severity. 8 Clearly, more work is needed to understand how these factors relate to one another.…”

Section: Comparison With Findings From Other Studiesmentioning

confidence: 99%

Subjective cognitive functioning in relation to changes in levels of depression and anxiety in youth over 3 months of treatment

et al. 2020

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Background Subjective cognitive difficulties are common in mental illness and have a negative impact on role functioning. Little is understood about subjective cognition and the longitudinal relationship with depression and anxiety symptoms in young people. Aims To examine the relationship between changes in levels of depression and anxiety and changes in subjective cognitive functioning over 3 months in help-seeking youth. Method This was a cohort study of 656 youth aged 12–25 years attending Australian headspace primary mental health services. Subjective changes in cognitive functioning (rated as better, same, worse) reported after 3 months of treatment was assessed using the Neuropsychological Symptom Self-Report. Multivariate multinomial logistic regression analysis was conducted to evaluate the impact of baseline levels of and changes in depression (nine-item Patient Health Questionnaire; PHQ9) and anxiety symptoms (seven-item Generalised Anxiety Disorder scale; GAD7) on changes in subjective cognitive function at follow-up while controlling for covariates. Results With a one-point reduction in PHQ9 at follow-up, there was an estimated 11–18% increase in ratings of better subjective cognitive functioning at follow-up, relative to stable cognitive functioning. A one-point increase in PHQ9 from baseline to follow-up was associated with 7–14% increase in ratings of worse subjective cognitive functioning over 3 months, relative to stable cognitive functioning. A similar attenuated pattern of findings was observed for the GAD7. Conclusions A clear association exists between subjective cognitive functioning outcomes and changes in self-reported severity of affective symptoms in young people over the first 3 months of treatment. Understanding the timing and mechanisms of these associations is needed to tailor treatment.

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Section: Comparison With Findings From Other Studiesmentioning

confidence: 99%

Subjective cognitive functioning in relation to changes in levels of depression and anxiety in youth over 3 months of treatment

et al. 2020

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“…This finding is not unexpected, as several other studies have also found discrepancies between self-reported measures and performance tests of cognitive symptoms in patients with MDD. 25,26,[48][49][50][51] For example, in a study in the United States involving 602 patients with MDD reporting cognitive symptoms, 64% met criteria for objectively defined cognitive impairment assessed using a battery of neuropsychological tests (including the DSST) and 48% met criteria for subjectively defined cognitive impairment assessed using the Cognitive and Physical Functioning Questionnaire (CPFQ). 50 Overall, 80% of patients met criteria for either subjective or objective cognitive impairment; however, only 31% met both criteria.…”

Section: Discussionmentioning

confidence: 99%

<p>Impact of Cognitive Symptoms on Health-Related Quality of Life and Work Productivity in Chinese Patients with Major Depressive Disorder: Results from the PROACT Study</p>

Wang¹,

Tan²,

Ren³

et al. 2020

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Purpose: This post hoc analysis was undertaken to further explore the association of cognitive symptoms with health-related quality of life (HRQoL) and work productivity at the time of treatment initiation in Chinese patients with major depressive disorder (MDD) in the Prospective Research Observation to Assess Cognition in Treated patients with MDD (PROACT) study. Patients and Methods: This was an epidemiological, non-interventional, prospective cohort study in adult outpatients with moderate-to-severe MDD initiating antidepressant monotherapy (first or second line). Crude and adjusted analyses of covariance were performed to assess the association of perceived cognitive symptoms (20-item Perceived Deficits Questionnaire-Depression [PDQ-D] total score) or observed cognitive performance (Digit Symbol Substitution Test [DSST] score) with HRQoL (EuroQoL 5-Dimensions Questionnaire index) and work productivity (Work Productivity and Activity Impairment [WPAI] or Sheehan Disability Scale [SDS] absenteeism and presenteeism scores). Adjusted analyses included depression severity, age, sex, residential area (urban/rural), and educational level. Results: Of 1008 patients enrolled in the PROACT study, 986 were included in this analysis. Severity of perceived cognitive symptoms (ie, higher PDQ-D total score) was significantly associated with worse HRQoL (P<0.001) and higher levels of absenteeism (P=0.020 for the WPAI and P=0.002 for the SDS) and presenteeism (P<0.001 for both scales). The association of perceived cognitive symptoms with HRQoL and presenteeism was independent of depression severity. The association between observed cognitive performance (DSST score) and HRQoL was less robust. No association was seen between observed cognitive performance and levels of absenteeism or presenteeism assessed by either scale. Conclusion: Results of this real-world study illustrate the impact of cognitive symptoms on HRQoL and work productivity in Chinese patients with MDD, and highlight the importance of assessing and targeting cognitive symptoms in order to improve functional outcomes when treating patients with MDD.

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“…Dazu sollte man standardisierte und objektivierende Test-und Diagnostikverfahren einbeziehen. Selbstauskünfte über das Leistungsvermögen sind oft wenig präzise und verlässlich und haben einen nur geringen Zusammenhang mit dem messbaren Leistungsvermögen [26]. Hilfreich erscheint hier, persönliche und soziale Ressourcen zu bestimmen, die im bisherigen und zukünftig zu erwartenden Krankheitsverlauf stabil sind, verlässlich erscheinen und verfügbar sind.…”

Section: Identifikation Und Diagnostikunclassified