Biased inheritance of mitochondria during asymmetric cell division in the mouse oocyte

Dalton, Caroline; Carroll, John

doi:10.1242/dev.100685

Cited by 16 publications

(21 citation statements)

References 1 publication

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“…In addition to these nuclear events, many cytoplasmic changes also occur during maturation. These include changes in the ultrastructure of the endoplasmic reticulum (Mehlmann et al 1995;Payne and Schatten 2003), migration of the cortical granules to just underneath the plasma membrane (Liu et al 2003;Nicosia et al 1977), and accumulation of the mitochondria around the meiotic spindle (Dalton and Carroll 2013;Van Blerkom et al 2003). Many previously silent mRNAs become translationally activated, whereas others become silenced and in some cases degraded (Clarke 2012;Kang and Han 2011).…”

Section: Overview Of Oogenesis and Folliculogenesismentioning

confidence: 99%

Control of Oocyte Growth and Development by Intercellular Communication Within the Follicular Niche

El‐Hayek

Clarke

2016

Results and Problems in Cell Differentiation

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In the mammalian ovary, each oocyte grows and develops within its own structural and developmental niche-the follicle. Together with the female germ cell in the follicle are somatic granulosa cells, specialized companion cells that surround the oocyte and provide support to it, and an outer layer of thecal cells that serve crucial roles including steroid synthesis. These follicular compartments function as a single physiological unit whose purpose is to produce a healthy egg, which upon ovulation can be fertilized and give rise to a healthy embryo, thus enabling the female germ cell to fulfill its reproductive potential. Beginning from the initial stage of follicle formation and until terminal differentiation at ovulation, oocyte and follicle growth depend absolutely on cooperation between the different cellular compartments. This cooperation synchronizes the initiation of oocyte growth with follicle activation. During growth, it enables metabolic support for the follicle-enclosed oocyte and allows the follicle to fulfill its steroidogenic potential. Near the end of the growth period, intra-follicular interactions prevent the precocious meiotic resumption of the oocyte and ensure its nuclear differentiation. Finally, cooperation enables the events of ovulation, including meiotic maturation of the oocyte and expansion of the cumulus granulosa cells. In this chapter, we discuss the cellular interactions that enable the growing follicle to produce a healthy oocyte, focusing on the communication between the germ cell and the surrounding granulosa cells.

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Section: Overview Of Oogenesis and Folliculogenesismentioning

confidence: 99%

Control of Oocyte Growth and Development by Intercellular Communication Within the Follicular Niche

El‐Hayek

Clarke

2016

Results and Problems in Cell Differentiation

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“…Rapidly, the first meiotic spindle forms, rarely at the perfect cell center but slightly off-centered 10,11 . At that stage, the oocyte bears no apparent sign of polarization [12][13][14] . The spindle then migrates along its long axis towards the closest cortex 10 .…”

mentioning

confidence: 98%

A narrow window of cortical tension guides asymmetric spindle positioning in the mouse oocyte

Chaigne¹,

Campillo²,

Gov³

et al. 2015

Nat Commun

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Cell mechanics control the outcome of cell division. In mitosis, external forces applied on a stiff cortex direct spindle orientation and morphogenesis. During oocyte meiosis on the contrary, spindle positioning depends on cortex softening. How changes in cortical organization induce cortex softening has not yet been addressed. Furthermore, the range of tension that allows spindle migration remains unknown. Here, using artificial manipulation of mouse oocyte cortex as well as theoretical modelling, we show that cortical tension has to be tightly regulated to allow off-center spindle positioning: a too low or too high cortical tension both lead to unsuccessful spindle migration. We demonstrate that the decrease in cortical tension required for spindle positioning is fine-tuned by a branched F-actin network that triggers the delocalization of myosin-II from the cortex, which sheds new light on the interplay between actin network architecture and cortex tension.

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“…It has long been known that mouse genomes in first and second polar bodies can contribute to efficient full-term development 20,21 . Moreover, mitochondria are largely excluded from the first polar body 34,59 . With this in mind, recent studies in mice have compared donor mitochondrial carryover from four MRT protocols: PB1T, PB2T, MST and PNT 34 .…”

Section: Mitophagymentioning

confidence: 99%

Assisted reproductive technologies to prevent human mitochondrial disease transmission

et al. 2017

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Biased inheritance of mitochondria during asymmetric cell division in the mouse oocyte

Cited by 16 publications

References 1 publication

Control of Oocyte Growth and Development by Intercellular Communication Within the Follicular Niche

Control of Oocyte Growth and Development by Intercellular Communication Within the Follicular Niche

A narrow window of cortical tension guides asymmetric spindle positioning in the mouse oocyte

Assisted reproductive technologies to prevent human mitochondrial disease transmission

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