Biased Immunoglobulin G (IgG) Subclass Production in a Case of Hyper-IgM Syndrome

McLean, Gary R.; Miller, Kenzie; Schrader, John W.; Junker, Anne

doi:10.1128/cdli.11.6.1192-1193.2004

Cited by 2 publications

(1 citation statement)

References 12 publications

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“…Accordingly, a serum, containing high levels of IgM, from X-HIGM patient infected with Helicobacter pylori displayed a 100% killing activity, when tested in a complement-mediated bactericidal assay [ 30 ]. It has been documented that sera from X-HIGM patients in addition to normal or elevated concentrations of IgM also contain IgG and IgA in low concentrations, but IgG3 levels are almost normal [ 31 ]. IgG3 and IgM isotypes are the more efficient complement-fixing human antibodies [ 28 ].…”

Section: Discussionmentioning

confidence: 99%

CD40 Ligand Deficient C57BL/6 Mouse Is a Potential Surrogate Model of Human X-Linked Hyper IgM (X-HIGM) Syndrome for Characterizing Immune Responses against Pathogens

López-Saucedo

Bernal-Reynaga

Zayas-Jahuey

et al. 2015

BioMed Research International

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Individuals with X-HIGM syndrome fail to express functional CD40 ligand; consequently they cannot mount effective protective antibody responses against pathogenic bacteria. We evaluated, compared, and characterized the humoral immune response of wild type (WT) and C57-CD40L deficient (C57-CD40L−/−) mice infected with Citrobacter rodentium. Basal serum isotype levels were similar for IgM and IgG3 among mice, while total IgG and IgG2b concentrations were significantly lower in C57-CD40L−/− mice compared with WT. Essentially IgG1 and IgG2c levels were detectable only in WT mice. C57-CD40L−/− animals, orally inoculated with 2 × 109 CFU, presented several clinical manifestations since the second week of infection and eventually died. In contrast at this time point no clinical manifestations were observed among C57-CD40L−/− mice infected with 1 × 107 CFU. Infection was subclinical in WT mice inoculated with either bacterial dose. The serum samples from infected mice (1 × 107 CFU), collected at day 14 after infection, had similar C. rodentium-specific IgM titres. Although C57-CD40L−/− animals had lower IgG and IgG2b titres than WT mice, C57-CD40L−/− mice sera displayed complement-mediated bactericidal activity against C. rodentium. C. rodentium-infected C57-CD40L−/− mice are capable of producing antibodies that are protective. C57-CD40L−/− mouse is a useful surrogate model of X-HIGM syndrome for studying immune responses elicited against pathogens.

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Section: Discussionmentioning

confidence: 99%

CD40 Ligand Deficient C57BL/6 Mouse Is a Potential Surrogate Model of Human X-Linked Hyper IgM (X-HIGM) Syndrome for Characterizing Immune Responses against Pathogens

López-Saucedo

Bernal-Reynaga

Zayas-Jahuey

et al. 2015

BioMed Research International

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Indications and safety of intravenous and subcutaneous immunoglobulin therapy

Rezaei

Abolhassani

Aghamohammadi

et al. 2011

Expert Review of Clinical Immunology

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Immunoglobulin (Ig) therapy is an important method of treatment for a number of immunological, hematological, neurological and dermatological disorders. Over the years, the range of indications in which Ig therapy, either replacement or immunomodulatory, is effective has substantially increased. Although Ig therapy was originally limited to intramuscular injection, intravenous infusion has became the most frequent route of administration, followed by subcutaneous injection. This article presents current information on indications, mechanisms of action, efficacy and practical aspects of intravenous and subcutaneous Ig replacement/immunomodulatory therapy as well as associated adverse reactions.

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Biased Immunoglobulin G (IgG) Subclass Production in a Case of Hyper-IgM Syndrome

Cited by 2 publications

References 12 publications

CD40 Ligand Deficient C57BL/6 Mouse Is a Potential Surrogate Model of Human X-Linked Hyper IgM (X-HIGM) Syndrome for Characterizing Immune Responses against Pathogens

CD40 Ligand Deficient C57BL/6 Mouse Is a Potential Surrogate Model of Human X-Linked Hyper IgM (X-HIGM) Syndrome for Characterizing Immune Responses against Pathogens

Indications and safety of intravenous and subcutaneous immunoglobulin therapy

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