Biased Effect of Cardiotonic Steroids on Na/K-ATPase–Mediated Signal Transduction

Xu, Yunlong; Marck, Pauline; Huang, Minqi; Xie, Junyi; Wang, Tong; Shapiro, Joseph I.; Cai, Liquan; Feng, Feng; Xie, Zijian

doi:10.1124/molpharm.120.000101

Cited by 8 publications

(2 citation statements)

References 48 publications

(45 reference statements)

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“…How can this be explained? A number of studies have reported that Na,K-ATPase undergoes internalization/endocytosis upon ouabain binding [ 70 , 71 ]. Chronic administration of ouabain (1 µg/kg/day for four days), which doubled circulating ouabain level [ 44 , 72 ], reduced the α2 Na,K-ATPase membrane content in the rat diaphragm and soleus muscles [ 73 ].…”

Section: Discussionmentioning

confidence: 99%

Short-Term Mild Hypoxia Modulates Na,K-ATPase to Maintain Membrane Electrogenesis in Rat Skeletal Muscle

Кравцова

Fedorova

Tishkova

et al. 2022

IJMS

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The Na,K-ATPase plays an important role in adaptation to hypoxia. Prolonged hypoxia results in loss of skeletal muscle mass, structure, and performance. However, hypoxic preconditioning is known to protect against a variety of functional impairments. In this study, we tested the possibility of mild hypoxia to modulate the Na,K-ATPase and to improve skeletal muscle electrogenesis. The rats were subjected to simulated high-altitude (3000 m above sea level) hypobaric hypoxia (HH) for 3 h using a hypobaric chamber. Isolated diaphragm and soleus muscles were tested. In the diaphragm muscle, HH increased the α2 Na,K-ATPase isozyme electrogenic activity and stably hyperpolarized the extrajunctional membrane for 24 h. These changes were accompanied by a steady increase in the production of thiobarbituric acid reactive substances as well as a decrease in the serum level of endogenous ouabain, a specific ligand of the Na,K-ATPase. HH also increased the α2 Na,K-ATPase membrane abundance without changing its total protein content; the plasma membrane lipid-ordered phase did not change. In the soleus muscle, HH protected against disuse (hindlimb suspension) induced sarcolemmal depolarization. Considering that the Na,K-ATPase is critical for maintaining skeletal muscle electrogenesis and performance, these findings may have implications for countermeasures in disuse-induced pathology and hypoxic therapy.

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Section: Discussionmentioning

confidence: 99%

Short-Term Mild Hypoxia Modulates Na,K-ATPase to Maintain Membrane Electrogenesis in Rat Skeletal Muscle

Кравцова

Fedorova

Tishkova

et al. 2022

IJMS

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“…Cardiotonic steroids (CTS) are part of a group of specific ligands of Na + , K + -ATPase, a ubiquitously expressed enzyme responsible for the maintenance of electrochemical gradients across the cell membrane through active transport[ 96 ] that provokes a variety of cell signals[ 70 ]. In the last decades, studies have revealed the role of Na + , K + -ATPase and its signaling in various diseases, including inflammation and fibrosis[ 97 ].…”

Section: Other Novel Markersmentioning

confidence: 99%

Promising diagnostic biomarkers of nonalcoholic fatty liver disease and nonalcoholic steatohepatitis: From clinical proteomics to microbiome

Castillo-Castro¹,

Martagón-Rosado²,

Ortı́z-López³

et al. 2021

WJH

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Fatty liver has been present in the lives of patients and physicians for almost two centuries. Vast knowledge has been generated regarding its etiology and consequences, although a long path seeking novel and innovative diagnostic biomarkers for nonalcoholic fatty liver disease (NAFLD) and nonalcoholic steatohepatitis (NASH) is still envisioned. On the one hand, proteomics and lipidomics have emerged as potential noninvasive resources for NAFLD diagnosis. In contrast, metabolomics has been able to distinguish between NAFLD and NASH, even detecting degrees of fibrosis. On the other hand, genetic and epigenetic markers have been useful in monitoring disease progression, eventually functioning as target therapies. Other markers involved in immune dysregulation, oxidative stress, and inflammation are involved in the instauration and evolution of the disease. Finally, the fascinating gut microbiome is significantly involved in NAFLD and NASH. This review presents state-of-the-art biomarkers related to NAFLD and NASH and new promises that could eventually be positioned as diagnostic resources for this disease. As is evident, despite great advances in studying these biomarkers, there is still a long path before they translate into clinical benefits.

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Zika virus: Antiviral immune response, inflammation, and cardiotonic steroids as antiviral agents

de Sales-Neto,

Madruga Carvalho,

Arruda Magalhães

et al. 2024

International Immunopharmacology

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Biased Effect of Cardiotonic Steroids on Na/K-ATPase–Mediated Signal Transduction

Cited by 8 publications

References 48 publications

Short-Term Mild Hypoxia Modulates Na,K-ATPase to Maintain Membrane Electrogenesis in Rat Skeletal Muscle

Short-Term Mild Hypoxia Modulates Na,K-ATPase to Maintain Membrane Electrogenesis in Rat Skeletal Muscle

Promising diagnostic biomarkers of nonalcoholic fatty liver disease and nonalcoholic steatohepatitis: From clinical proteomics to microbiome

Zika virus: Antiviral immune response, inflammation, and cardiotonic steroids as antiviral agents

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