Bias in the measurement of radon gas using ionization chambers: Application to SIR

Pierre, Sylvie; Sabot, Benoît; Cassette, P.; Liang, Juncheng; Courte, S; Ferreux, L.; Ratel, G

doi:10.1016/j.apradiso.2017.10.040

Applied Radiation and Isotopes

2018

DOI: 10.1016/j.apradiso.2017.10.040

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Bias in the measurement of radon gas using ionization chambers: Application to SIR

Sylvie Pierre

Benoît Sabot

P. Cassette

et al.

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Cited by 2 publications

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References 11 publications

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“…More recently, bias in measurements of gaseous 222 Rn using ICs were investigated at the LNHB (Pierre et al, 2018). In this previous work, several measurements were carried out at the LNHB and at the BIPM and the variability of the response of ICs was investigated by considering the volume of the ampoule, the position of the sealing point and the thickness of the ampoule's base, which does not play a major role.…”

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confidence: 99%

Simulation of the response of an ionization chamber to 214Bi emission. Application to the measurement of 222Rn

Pierre

Thiam

Cassette

et al. 2019

Applied Radiation and Isotopes

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PENELOPE simulations of a Vinten ionization chamber (IC) were performed to investigate the influence of the thickness of glass-ampoules used in 222 Rn standardization. The simulation reveals a non-negligible variation of the energy deposited in the chamber gas region (which may induce a proportional variation of the measured current) when considering the  transition emissions of the daughters of 222 Rn. This reinforces the idea of using a specialist container (made of metal to preserve the integrity of the container) that would circulate between the metrology laboratories in the context of international comparison exercises using the BIPM international reference system (SIR)..

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mentioning

confidence: 99%

Simulation of the response of an ionization chamber to 214Bi emission. Application to the measurement of 222Rn

Pierre

Thiam

Cassette

et al. 2019

Applied Radiation and Isotopes

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Compatibility of [99mTc]Tc-EDDA/HYNIC-TOC and [68Ga] Ga-DOTA-TOC in a syringe for intravenous administration

Chaib

Hallouard

Chennell

et al. 2020

Nuclear Medicine Communications

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Objective Drug quality in medical devices is not evaluated during the marketing authorization of radiopharmaceuticals. Therefore, the extemporaneous change of packaging made for preparation of patient unit doses in a syringe is the responsibility of radiopharmacists. The present study aimed to determine the impact of packaging and storage in a polypropylene syringe on the quality of hydrophilic drugs [99mTc]Tc-EDDA/HYNIC-TOC (Tektrotyd) and [68Ga]Ga-DOTA-TOC (Somakit-TOC). Methods Appearance, pH, radiochemical purity, sterility, and endotoxin tests were performed according the current European Pharmacopoeia. Subvisible and visible particles tests of the European Pharmacopoeia were adapted due to limited preparation volume (<25 ml). Sorption tests were performed according to the literature. Results After 2 h storage in a syringe, drug sorption of Tektrotyd and Somakit-TOC was of less than 2.5% and similar to other 99mTc-radiopharmaceuticals (range: from 1.1 ± 0.5% to 4.2 ± 0.6%). For Tektrotyd, this sorption phenomenon was positively influenced by the drug concentration and a short contact with the medical device (4.8 ± 0.2% up to 5 s vs. 2.3 ± 0.2%, n = 4; P < 0.001). For Somakit-TOC, the duration of contact with syringe had no impact (1.6 ± 0.2% up to 5 s vs. 1.7 ± 0.6%; P = 1.000). No drug radiolysis or alteration of microbiological aspects were observed. No impurity from a 3-piece-syringe was observed according to drug aspect, pH, and subvisible and visible particles, which remained within specification of the current European Pharmacopoeia. Conclusion This study found that drug sorption to packaging was compatible with clinical use and absence of drug alteration of Tektrotyd and Somakit-TOC after repackaging in a syringe in polypropylene and prolonged storage during 2 h.

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Bias in the measurement of radon gas using ionization chambers: Application to SIR

Cited by 2 publications

References 11 publications

Simulation of the response of an ionization chamber to 214Bi emission. Application to the measurement of 222Rn

Simulation of the response of an ionization chamber to 214Bi emission. Application to the measurement of 222Rn

Compatibility of [99mTc]Tc-EDDA/HYNIC-TOC and [68Ga] Ga-DOTA-TOC in a syringe for intravenous administration

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