“…However, in order to capitalize on these opportunities, a number of challenges must be surmounted. A major challenge in secondary research of EHRs is data quality, namely completeness and accuracy (Hripcsak, Knirsch, Zhou, Wilcox, & Melton, 2011;Orueta et al, 2012;Spooner & Kirkendall, 2012;Teasdale, Bates, Kmetik, Suzewits, & Bainbridge, 2007;Tolar & Balka, 2012;Weiner, Lyman, Murphy, & Weiner, 2007;Weiskopf & Weng, 2012), discrepancies/inconsistencies in data (Orueta et al, 2012;Weiner et al, 2007) and interoperability (Jensen et al, 2012;Spooner & Kirkendall, 2012). There are also significant ethical issues, such as privacy and informed consent, that emerge in secondary research of EHRs (see, e.g.…”