Biamperometric Determination of Tetracycline in Pharmaceuticals

Neto, Francisco Fernandes Gambarra; Lima, Renato S.; Lyra, Wellington da Silva; Marino, Glimaldo; Araújo, Mário César Ugulino de; Medeiros, Everaldo S.; Nascimento, Valberes B.

doi:10.1080/00032710701646115

Cited by 8 publications

(3 citation statements)

References 21 publications

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“…Tetracycline capsule sample was prepared following the reported procedure [ 1 ] with minor modification. Briefly: TC capsules (EPHARM brand) with a nominal content of 250 mg/capsule were purchased from a pharmacy in Bahir Dar city, Ethiopia.…”

Section: Experimental Partmentioning

confidence: 99%

“…Tetracyclines constitute a family of well-known broad-spectrum antibiotics routinely used for prevention and control of diseases in human and veterinary medicine. They inhibit bacteria's protein synthesis by blocking ribosome action against the linking of aminoacil-tRNA's and destroy bacterial cellular membrane [ 1 ]. Moreover, they also find wide applications as a feed additive for cattle breeding; as an alternative drug for people allergic to penicillin; and in the control of plant diseases [ 1 ].…”

Section: Introductionmentioning

confidence: 99%

“…They inhibit bacteria's protein synthesis by blocking ribosome action against the linking of aminoacil-tRNA's and destroy bacterial cellular membrane [ 1 ]. Moreover, they also find wide applications as a feed additive for cattle breeding; as an alternative drug for people allergic to penicillin; and in the control of plant diseases [ 1 ]. In human medicine, tetracycline antibiotics also have been used for the treatment of different types of infections, including respiratory tract infections, urethritis and severe acene [ 2 ].…”

Section: Introductionmentioning

confidence: 99%

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Adsorptive stripping voltammetric determination of Tetracycline in pharmaceutical capsule formulation using Poly(Malachite green) modified glassy carbon electrode

Turbale

Moges

Dawit

et al. 2020

Heliyon

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A selective and sensitive electrochemical method based on glassy carbon electrode modified with poly(malachite green) was developed for determination of tetracycline in pharmaceutical capsule formulation. Cyclic voltammetry and electrochemical impedance spectroscopy using [Fe(CN) 6 ] 3-/4- as a probe were used to characterize the potentiodynamiclly deposited poly(malachite green) on the surface of glassy carbon electrode. In contrast to the unmodified glassy carbon electrode, the fabricated poly(malachite green) modified glassy carbon electrode showed catalytic property towards two steps irreversible oxidation of tetracycline. Better correlation of the oxidative peak current with the scan rate than with the square root of scan rate supported by slope of 0.60 for log(current) versus log(scan rate) indicated that the oxidation reaction of tetracycline at the modified electrode was predominantly controlled by electron exchange step at the solution polymer interface. Under optimized solution pH, and accumulation parameters, the square wave adsorptive anodic striping peak current response of the modified electrode showed linear dependence on concentration of tetracycline in the range 5–100 μM with determination coefficient, method detection limit, and quantification limit of 0.99588, 1.6 μM, and 5.3 μM, respectively. The tetracycline content of a capsule sample claimed to have 250 mg/capsule was found to be 250.53 mg/capsule with 0.21% deviation. Excellent spike recovery result of 99.80%, and 98.49–99.78% recovery of tetracycline in capsule sample in the presence of 50–200% of UA, AA, and ampicillin validated the applicability of the method for determination of tetracycline in real samples with complex matrix like capsule formulations.

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Section: Experimental Partmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Adsorptive stripping voltammetric determination of Tetracycline in pharmaceutical capsule formulation using Poly(Malachite green) modified glassy carbon electrode

Turbale

Moges

Dawit

et al. 2020

Heliyon

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Tetracycline Potentiometric Sensor Based on Cyclodextrin for Pharmaceuticals and Waste Water Analysis

et al. 2010

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In this work, the construction and performance evaluation of PVC membranes ion-selective electrodes for the determination of tetracycline type antibiotics is described. Electrodes with the best responses were based on plastic membranes containing 31% (w/w) PVC, 68% (w/w) of dibutylphthalate as plasticizer and 1% (w/w) of b-cyclodextrin as ionophore. The electrodes were responsive over 6 months to tetracycline, oxytetracycline, doxycycline and chlortetracycline in glycine buffer solution (pH 2), in the dynamic range 2 10 À5 -10 À2 mol L À1 with a constant slope of about 55 mV/dec To enable large scale analysis reducing wastes as associated costs tubular shape electrodes were coupled to a sequential-injection analysis system and its performance evaluated using pharmaceutical samples and waste waters from a treatment facility. The sample throughput of 51 samples h À1 was enabled by the system as well as results that favorably agree with those provided by chromatographic analysis.

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Miniaturized Biamperometric Detectors for Electrochemical Detection in Flowing Streams

2017

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Capillary electrochemical detectors with various configurations of electrodes were developed by inserting platinum multielectrodes (tetrodes) or platinum and carbon microelectrodes into the ending of capillaries. The biamperometric mode of detection, without the need of classical reference electrode, was employed in flow injection analysis of dopamine and norepinephrine selected as model samples. The influences of geometric shape of tetrodes, arrangement of electrodes and internal diameter of the capillary were studied thoroughly with respect to intensity of recorded currents. A novel pulse biamperometric technique was employed with the aim to enhance further the recorded currents of dopamine oxidation and to minimize the passivation of electrodes in mixed aqueous‐organic carrier solution, which improved considerably the repeatability of measurements. Proposed low‐cost microelectrode devices showed good prospects as detectors in simple and miniaturized flow systems, such as flow injection analysis and capillary high‐performance liquid chromatography with monolithic columns.

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Biamperometric Determination of Tetracycline in Pharmaceuticals

Cited by 8 publications

References 21 publications

Adsorptive stripping voltammetric determination of Tetracycline in pharmaceutical capsule formulation using Poly(Malachite green) modified glassy carbon electrode

Adsorptive stripping voltammetric determination of Tetracycline in pharmaceutical capsule formulation using Poly(Malachite green) modified glassy carbon electrode

Tetracycline Potentiometric Sensor Based on Cyclodextrin for Pharmaceuticals and Waste Water Analysis

Miniaturized Biamperometric Detectors for Electrochemical Detection in Flowing Streams

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