Biallelic variants identified in 36 Pakistani families and trios with autism spectrum disorder
Hamid Khan,
Ricardo Harripaul,
Anna Mikhailov
et al.
Abstract:With its high rate of consanguineous marriages and diverse ethnic population, little is currently understood about the genetic architecture of autism spectrum disorder (ASD) in Pakistan. Pakistan has a highly ethnically diverse population, yet with a high proportion of endogamous marriages, and is therefore anticipated to be enriched for biallelic disease-relate variants. Here, we attempt to determine the underlying genetic abnormalities causing ASD in thirty-six small simplex or multiplex families from Pakist… Show more
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