Bi-phasic effect of gelatin in myogenesis and skeletal muscle regeneration

Liu, Xiao ling; Zu, Er; Chang, Xin Yu; Wang, Zi Qi; Li, Xiang Ru; Yu, Qi; Kamei, Kazuhito; Hayashi, Toshihiko; Mizuno, Kazunori; Hattori, Shunji; Fujisaki, Hitomi; Ikejima, Takashi; Wang, Dan Ohtan

doi:10.1101/2021.05.26.445744

Cited by 2 publications

(2 citation statements)

References 57 publications

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“…A low dose of gelatin results in an increased antioxidant response, tissue adaptation to mild stress, myogenesis, and muscle regeneration. A high amount of gelatin causes ROS overproduction, leading to a worse tissue injury [66]. Therefore, ROS has a biphasic effect.…”

Section: Exercise Produces Both Ros and Antioxidantmentioning

confidence: 99%

The Role of Exercise-Induced Reactive Oxygen Species (ROS) Hormesis in Aging: Friend or Foe

Lesmana

Parameswari

Mandagi

et al. 2022

Cell Physiol Biochem

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Reactive oxygen species (ROS) are oxygen derivatives that arise intrinsically from the oxidative phosphorylation process and extrinsically as a response to xenobiotics and pollution. ROS is involved in various conditions such as exercise, aging, inflammation, and neurodegenerative diseases. In the aging process, increased cellular senescence and decreased endogenous antioxidants also occur. Meanwhile, physical activity, specifically exercise, can modulate ROS. The impact of exercise on ROS varies from harmful to beneficial and depends on the type of exercise as they induce different types of ROS. Long-term exercise regulates signaling pathways that enhance antioxidant defense systems and control ROS production. This review will discuss studies on how exercise can regulate ROS and which type of exercise has a role in delaying the aging process. This review also exposes the impact of nutraceutical antioxidant agents that likely enhance the benefit of exercise. The nutraceutical antioxidants agents that likely enhance the benefit of exercise are creatine, whey, and ascorbic acid. Exercise is rewarding for the aging population concerning increasing their quality of life. Special consideration to exercise needs to be given to the type of exercise, and the exercise must be done continuously.

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Section: Exercise Produces Both Ros and Antioxidantmentioning

confidence: 99%

The Role of Exercise-Induced Reactive Oxygen Species (ROS) Hormesis in Aging: Friend or Foe

Lesmana

Parameswari

Mandagi

et al. 2022

Cell Physiol Biochem

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show abstract

“…TNF and dexamethasone can exert their opposite effects on myogenesis (myogenic) and myotube loss (pro-inflammatory). Gelatin also has a dose-dependent bi-phasic effect on myogenesis [36].…”

Section: Accepted Manuscriptmentioning

confidence: 99%

A Lignan from Alnus japonica Activates Myogenesis and Alleviates Dexamethasone-induced Myotube Atrophy

et al. 2022

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To find inhibitors against skeletal muscle loss, we isolated a lignan compound ((-)-(2 R ,3R-1,4-Ο-diferuloylsecoisolarciresinol, DFS) from the stem of Alnus japonica. C2C12 myoblasts were treated with DFS during differentiation. To induce an in vitro atrophic condition, differentiated myotubes were treated with dexamethasone (a synthetic glucocorticoid). DFS (10 nM) increased expression levels of myogenic factors and the number of multi-nucleated myotubes expressing myosin heavy chain (MHC). The myogenic potential of DFS could be attributed to p38 MAPK activation. DFS also protected against dexamethasone-induced damage showing increased expression of MHC and mammalian target of rapamycin (mTOR), a major anabolic factor. Under atrophic condition, the anti-myopathy effect of DFS was associated with inactivation of NF-κB signaling pathway and the subsequent suppression of muscle degradative E3 ligases and myostatin. DFS treatment also restored fast muscle fiber (type IIa, IIb, and IIx) known to be susceptible to dexamethasone. These results indicate that DFS isolated from A. japonica can stimulate myogenesis via p38 MAPK activation and alleviate muscle atrophy by modulating the expression of genes associated with muscle protein anabolism/catabolism. Thus, we propose that DFS can be used as a pharmacological and nutraceutical agent for increasing muscle strength or protecting muscle loss.

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Bi-phasic effect of gelatin in myogenesis and skeletal muscle regeneration

Cited by 2 publications

References 57 publications

The Role of Exercise-Induced Reactive Oxygen Species (ROS) Hormesis in Aging: Friend or Foe

The Role of Exercise-Induced Reactive Oxygen Species (ROS) Hormesis in Aging: Friend or Foe

A Lignan from Alnus japonica Activates Myogenesis and Alleviates Dexamethasone-induced Myotube Atrophy

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