Bi-material attachment through a compliant interfacial system at the tendon-to-bone insertion site

Liu, Yanxin; Thomopoulos, Stavros; Birman, Victor; Li, Jr-Shin; Genin, Guy M.

doi:10.1016/j.mechmat.2011.08.005

Cited by 87 publications

(82 citation statements)

References 49 publications

(60 reference statements)

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“…Gradients in mineral content and collagen fiber organization at the microscale (9,10), and 3. Functional grading at the millimeter scale (1,11,12).…”

Section: Introductionmentioning

confidence: 99%

Stochastic Interdigitation as a Toughening Mechanism at the Interface between Tendon and Bone

Birman²,

Deymier-Black

et al. 2015

Biophysical Journal

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Reattachment and healing of tendon to bone poses a persistent clinical challenge and often results in poor outcomes, in part because the mechanisms that imbue the uninjured tendon-to-bone attachment with toughness are not known. One feature of typical tendon-to-bone surgical repairs is direct attachment of tendon to smooth bone. The native tendon-to-bone attachment, however, presents a rough mineralized interface that might serve an important role in stress transfer between tendon and bone. In this study, we examined the effects of interfacial roughness and interdigital stochasticity on the strength and toughness of a bimaterial interface. Closed form linear approximations of the amplification of stresses at the rough interface were derived and applied in a two-dimensional unit-cell model. Results demonstrated that roughness may serve to increase the toughness of the tendon-to-bone insertion site at the expense of its strength. Results further suggested that the natural tendon-to-bone attachment presents roughness for which the gain in toughness outweighs the loss in strength. More generally, our results suggest a pathway for stochasticity to improve surgical reattachment strategies and structural engineering attachments.

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“…Gradients in mineral content and collagen fiber organization at the microscale (9,10), and 3. Functional grading at the millimeter scale (1,11,12).…”

Section: Introductionmentioning

confidence: 99%

Stochastic Interdigitation as a Toughening Mechanism at the Interface between Tendon and Bone

Birman²,

Deymier-Black

et al. 2015

Biophysical Journal

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“…A number of mechanisms exist at multiple length scales at this interface to alleviate stress concentrations and allow for effective load transfer ( Fig. 1) [1][2][3]. At the millimeter length scale, the tendon attaches to the bone with a splayed geometry that dissipates stresses that would otherwise arise at the corners [4].…”

Section: Introductionmentioning

confidence: 99%

Allometry of the Tendon Enthesis: Mechanisms of Load Transfer Between Tendon and Bone

Deymier-Black

Pasteris²,

Genin

et al. 2015

Journal of Biomechanical Engineering

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Several features of the tendon-to-bone attachment were examined allometrically to determine load transfer mechanisms. The humeral head diameter increased geometrically with animal mass. Area of the attachment site exhibited a near isometric increase with muscle physiological cross section. In contrast, the interfacial roughness as well as the mineral gradient width demonstrated a hypoallometric relationship with physiologic cross-sectional area (PCSA). The isometric increase in attachment area indicates that as muscle forces increase, the attachment area increases accordingly, thus maintaining a constant interfacial stress. Due to the presence of constant stresses at the attachment, the micrometer-scale features may not need to vary with increasing load.

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“…[14,25] The presence of compressive forces has been postulated to aid in the reduction of stress concentrators in the enthesis, possibly indicating the origin of type II collagen. [26] These fibrillar collagens can further assemble into increasingly large fiber-like structures. This type of organization is found within the oriented soft tissue of the entheseal attachments and is typically associated with type I collagen.…”

Section: Materials Processing Methodsmentioning

confidence: 99%

Next generation tissue engineering of orthopedic soft tissue-to-bone interfaces

et al. 2017

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Soft tissue-to-bone interfaces are complex structures that consist of gradients of extracellular matrix materials, cell phenotypes, and biochemical signals. These interfaces, called entheses for ligaments, tendons, and the meniscus, are crucial to joint function, transferring mechanical loads and stabilizing orthopedic joints. When injuries occur to connected soft tissue, the enthesis must be re-established to restore function, but due to structural complexity, repair has proven challenging. Tissue engineering offers a promising solution for regenerating these tissues. This prospective review discusses methodologies for tissue engineering the enthesis, outlined in three key design inputs: materials processing methods, cellular contributions, and biochemical factors.

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Bi-material attachment through a compliant interfacial system at the tendon-to-bone insertion site

Cited by 87 publications

References 49 publications

Stochastic Interdigitation as a Toughening Mechanism at the Interface between Tendon and Bone

Stochastic Interdigitation as a Toughening Mechanism at the Interface between Tendon and Bone

Allometry of the Tendon Enthesis: Mechanisms of Load Transfer Between Tendon and Bone

Next generation tissue engineering of orthopedic soft tissue-to-bone interfaces

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