Bi&lt;sub&gt;2&lt;/sub&gt;S&lt;sub&gt;3&lt;/sub&gt; Nanoflowers Synthesized via Hydrothermal Method

Chen, Xi Liang; Ji, Yan Pei

doi:10.4028/www.scientific.net/amr.989-994.11

Cited by 2 publications

(2 citation statements)

References 20 publications

(22 reference statements)

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“…Several chromone derivatives have been screened toward a panel of cancer lines, namely, those bearing imidazolidinone methylamino-4-substituted-1,3-thiazoles and 4-morpholinothieno[3,2- d ]pyrimidine substituents. − The results gathered so far led to the following conclusions: (a) Derivatives based on the 7-methoxychromone scaffold have shown relevant cytotoxic effects in several cell lines (HL-60, KB, LLC, LNCaP, LU-1, MCF7, and SW480) . Additionally, several chromonylthiazolidines (compounds 27 and 28 , IC 50 = 44.1 μg/mL and IC 50 = 32.8 μg/mL, respectively, Figure ) have shown selective cytotoxic activity against human epidermoid carcinoma and breast cancer .…”

Section: Biological Interest Of Chromonesmentioning

confidence: 99%

Chromone as a Privileged Scaffold in Drug Discovery: Recent Advances

et al. 2017

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The use of privileged structures in drug discovery has proven to be an effective strategy, allowing the generation of innovative hits/leads and successful optimization processes. Chromone is recognized as a privileged structure and a useful template for the design of novel compounds with potential pharmacological interest, particularly in the field of neurodegenerative, inflammatory, and infectious diseases as well as diabetes and cancer. This perspective provides the reader with an update of an earlier article entitled "Chromone: A Valid Scaffold in Medicinal Chemistry" ( Chem. Rev. 2014 , 114 , 4960 - 4992 ) and is mainly focused on chromones of biological interest, including those isolated from natural sources. Moreover, as drug repurposing is becoming an attractive drug discovery approach, recent repurposing studies of chromone-based drugs are also reported.

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Section: Biological Interest Of Chromonesmentioning

confidence: 99%

Chromone as a Privileged Scaffold in Drug Discovery: Recent Advances

et al. 2017

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“…3-Substituted benzopyran-4-one derivatives have been identified as potential anticancer agents from biological screening on cancer cell lines. A few noteworthy examples include those bearing imidazolidinone methylamino-4-substituted-1,3-thiazoles and 4-morpholinothieno [3,2-d]pyrimidine substituents [ 12 , 13 , 14 , 15 ]. Furthermore, several chromonylthiazolidines were found to have selective cytotoxicity against human epidermoid carcinoma and breast cancer [ 16 ].…”

Section: Introductionmentioning

confidence: 99%

Design, Synthesis, and Antiproliferative Activity of Benzopyran-4-One-Isoxazole Hybrid Compounds

et al. 2023

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The biological significance of benzopyran-4-ones as cytotoxic agents against multi-drug resistant cancer cell lines and isoxazoles as anti-inflammatory agents in cellular assays prompted us to design and synthesize their hybrid compounds and explore their antiproliferative activity against a panel of six cancer cell lines and two normal cell lines. Compounds 5a–d displayed significant antiproliferative activities against all the cancer cell lines tested, and IC50 values were in the range of 5.2–22.2 μM against MDA-MB-231 cancer cells, while they were minimally cytotoxic to the HEK-293 and LLC-PK1 normal cell lines. The IC50 values of 5a–d against normal HEK-293 cells were in the range of 102.4–293.2 μM. Compound 5a was screened for kinase inhibitory activity, proteolytic human serum stability, and apoptotic activity. The compound was found inactive towards different kinases, while it completely degraded after 2 h of incubation with human serum. At 5 μM concentration, it induced apoptosis in MDA-MB-231 by 50.8%. Overall, these findings suggest that new benzopyran-4-one-isoxazole hybrid compounds, particularly 5a–d, are selective anticancer agents, potentially safe for human cells, and could be synthesized at low cost. Additionally, Compound 5a exhibits potential anticancer activity mediated via inhibition of cancer cell proliferation and induction of apoptosis.

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Bi<sub>2</sub>S<sub>3</sub> Nanoflowers Synthesized via Hydrothermal Method

Cited by 2 publications

References 20 publications

Chromone as a Privileged Scaffold in Drug Discovery: Recent Advances

Chromone as a Privileged Scaffold in Drug Discovery: Recent Advances

Design, Synthesis, and Antiproliferative Activity of Benzopyran-4-One-Isoxazole Hybrid Compounds

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