Bi-layered constructs of poly(glycerol-sebacate)-β-tricalcium phosphate for bone-soft tissue interface applications

Tevlek, Atakan; Hosseinian, Pezhman; Cansel, Ogutcu; Türk, Mustafa; Aydın, Halil Murat

doi:10.1016/j.msec.2016.11.082

Cited by 38 publications

(31 citation statements)

References 30 publications

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“…The findings on the cellular behavior of this study were exhibited similarity to our previous report regarding PGS . The change in pH of the culture medium with the acidic components released from PGS to the culture medium depending on the degree of crosslinking was proposed as the main cause of the observed cellular behavior.…”

Section: Resultssupporting

confidence: 90%

“…All reagents used as received, without further purification. PGS was synthesized according to a previously published method . The synthesis of PGS elastomer was accomplished in two steps: prepolymerization and curing.…”

Section: Methodsmentioning

confidence: 99%

“…Although β‐TCP has high biocompatibility, long shelf life, and ease of sterilization, it also has internal and uncontrolled fragility. In order to overcome this fragile property, it is often suggested to combine with biodegradable polymers to be used as composites . However, the shape‐recovery properties of these ceramic added composites obtained so far have not been investigated in detail in the literature.…”

Section: Introductionmentioning

confidence: 99%

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Stretchable poly(glycerol‐sebacate)/β‐tricalcium phosphate composites with shape recovery feature by extrusion

Tevlek

Agacik

Aydın

2019

J of Applied Polymer Sci

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There has been a great interest in research towards elastomers and their composites with an attempt to obtain the desired biological and mechanical response to scaffold materials in bone tissue engineering. Composites made of ceramic‐thermoplastic mixtures have been shown success to deliver the inorganic component while fail to provide replacement of an elastic protein, that is, collagen, of the target bone tissue. Thus, in order to match up with the inherent elasticity of the native tissue, it is proposed an alternative to well‐known thermoplastic‐containing matrices by using a poly(glycerol‐sebacate) (PGS)–beta‐tricalcium phosphate elastomeric composite to offer flexibility and mechanical integrity. This study reports for the first time a successful extrusion of PGS containing biodegradable composites with shape‐memory feature. The resulting structures are physically and chemically characterized. In vitro cell culture performance of the obtained materials is investigated by using an MC3T3‐E1 mouse preosteoblast cell line. The materials obtained in this study can be shaped into the desired size and various forms via temperature stimuli. Resulting materials have been proposed for craniofacial tissue engineering as a bone filler in which surgeons need to shape biomaterials during the surgical procedure due to the complex geometry of the bones. © 2019 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2019, 137, 48689.

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Section: Resultssupporting

confidence: 90%

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Stretchable poly(glycerol‐sebacate)/β‐tricalcium phosphate composites with shape recovery feature by extrusion

Tevlek

Agacik

Aydın

2019

J of Applied Polymer Sci

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“…Previously, increased culture time, dynamic mechanical loading during culture, and growth factor stimulation have shown to improve mechanics of tissue‐engineered interfaces and have potential to do the same if implemented in this system . Many of the approaches used for enthesis tissue engineering revolve around the use of gradients (compositional, cellular, chemical, or structural) to recreate this interfacial architecture …”

Section: Discussionmentioning

confidence: 99%

Cellular and Chemical Gradients to Engineer the Meniscus‐to‐Bone Insertion

Iannucci

Boys

McCorry

et al. 2018

Adv Healthcare Materials

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Tissue‐engineered menisci hold promise as an alternative to allograft procedures but require a means of robust fixation to the native bone. The insertion of the meniscus into bone is critical for meniscal function and inclusion of a soft tissue‐to‐bone interface in a tissue engineered implant can aid in the fixation process. The native insertion is characterized by gradients in composition, tissue architecture, and cellular phenotype, which are all difficult to replicate. In this study, a soft tissue‐to‐bone interface is tissue engineered with a cellular gradient of fibrochondrocytes and mesenchymal stem cells and subjected to a biochemical gradient through a custom media diffusion bioreactor. These constructs, consisting of interpenetrating collagen and boney regions, display improved mechanical performance and collagen organization compared to controls without a cellular or chemical gradient. Media gradient exposure produces morphological features in the constructs that appear similar to the native tissue. Collectively, these data show that cellular and biochemical gradients improve integration between collagen and bone in a tissue engineered soft tissue‐to‐bone construct.

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“…[143] An integrated gradient of BMP-2 and TGF-β1 has been shown to create a continuous material and phenotypic transition between cartilage and bone. [49,53] Application of growth factors is especially favorable when using a single progenitor cell type in the scaffold. Rather than seeding multiple cell types, growth factors can be incorporated to initiate the differentiation of stem cells.…”

Section: Biochemical Factorsmentioning

confidence: 99%

Next generation tissue engineering of orthopedic soft tissue-to-bone interfaces

et al. 2017

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Soft tissue-to-bone interfaces are complex structures that consist of gradients of extracellular matrix materials, cell phenotypes, and biochemical signals. These interfaces, called entheses for ligaments, tendons, and the meniscus, are crucial to joint function, transferring mechanical loads and stabilizing orthopedic joints. When injuries occur to connected soft tissue, the enthesis must be re-established to restore function, but due to structural complexity, repair has proven challenging. Tissue engineering offers a promising solution for regenerating these tissues. This prospective review discusses methodologies for tissue engineering the enthesis, outlined in three key design inputs: materials processing methods, cellular contributions, and biochemical factors.

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Bi-layered constructs of poly(glycerol-sebacate)-β-tricalcium phosphate for bone-soft tissue interface applications

Cited by 38 publications

References 30 publications

Stretchable poly(glycerol‐sebacate)/β‐tricalcium phosphate composites with shape recovery feature by extrusion

Stretchable poly(glycerol‐sebacate)/β‐tricalcium phosphate composites with shape recovery feature by extrusion

Cellular and Chemical Gradients to Engineer the Meniscus‐to‐Bone Insertion

Next generation tissue engineering of orthopedic soft tissue-to-bone interfaces

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