Bi-functional titanium-polydopamine-zinc coatings for infection inhibition and enhanced osseointegration

Abstract

The ideal orthopedic implant coating is expected to both inhibit microbial infection and promote osseointegration. In this study, Zn ions were immobilized on a Ti substrate via a polydopamine (PDA) chemical surface modification to prepare Ti-PDA-Zn coatings. Scanning electron microscopy (SEM), atomic force microscopy (AFM), energy-dispersive X-ray spectroscope (EDS), X-ray photoelectron spectroscopy (XPS), contact analysis system, and inductively coupled plasma atomic emission spectrometry (ICP-AES) were used to analyze the morphology, composition, wettability, and zinc ions release of the coatings. The Ti-PDA-Zn coatings demonstrated excellent antibacterial activities in vitro against both Staphylococcus aureus and Escherichia coli. The coatings additionally displayed good biocompatibility, as confirmed by cytoskeletal observations and cell viability assays. Furthermore, the in vivo results confirmed the excellent antibacterial properties and improved osseointegration capability of the Ti-PDA-Zn coating in the presence of S. aureus. The present findings indicate that the Ti-PDA-Zn coatings prepared herein have potential application in orthopedic implantation.

<p>Lanthanides-Substituted Hydroxyapatite/<em>Aloe vera</em> Composite Coated Titanium Plate for Bone Tissue Regeneration</p>

“…The dopamine hydrochloride was polymerized into PD by atmospheric oxygen, and the black layer was formed on the Ti surface. Then the PDcoated Ti (PD-Ti) plate was washed with water and ethanol to remove the uncoated particles and then dried at 60 ºC for 5 h. 40…”

Toward Designing of Anti-infective Hydrogels for Orthopedic Implants: From Lab to Clinic

“…The applicability of hydrogels as implant coatings is governed by their adhesion behavior. Probably the hydrogels may not be straightaway coated over the implant surface as their adhesion gets weakened by the water content in the physiological system. , In this regard, ample methodologies have been devised to validate strong adhesion between the hydrogel coating and the implant surface, in particular via chemical or physical treatment. − For orthopedic implants, especially Ti-based, mussel inspired polydopamine (PDA) coatings have drawn much attention, thanks to their versatility and adaptability to countless surfaces. Similar to mussel foot adhesive proteins, the remarkable adhesive property of PDA can be assigned to its unique structure endowed with functional groups viz catechol and multiple amines. − Jeong and colleagues demonstrated enhancement in the adhesion of gelatin hydrogel to three different implant surfaces (aluminum (Al), Ti, and PMMA) via coating the implants with PDA .…”

Atmospheric pressure plasma liquid assisted deposition of polydopamine/acrylate copolymer on zirconia (Y-TZP) ceramics: a biocompatible and adherent nanofilm

“…The response of PDA self-polymerized on plastics, titanium, and ceramic substrates (including zirconia) with enhanced osteoblastic adhesion towards cells has been extensively investigated using in vitro assays. 29,30,36,45 However, deep research on the effect of PDA and derivatives synthesized by atmospheric plasma was never approached.…”

“…18,[23][24][25] In this work, for the rst time, organically modied Y-TZP discs containing polydopamine and acrylate biocompatible polymer were successfully prepared by applying liquid-assisted atmospheric-pressure plasma-induced polymerization (LA-APPiP). The nanocoating was designed to contain polydopamine molecules, [26][27][28] which promote surface adhesion due to catecholamine groups 29 and biominerals formation, 30,31 such as calcium phosphates and hydroxyapatites, that are responsible for the rapid osseointegration of medical implants. 32,33 Moreover, the acrylate polymer, ethylene glycol dimethacrylate (EGDMA), exhibits biocompatibility, insignicant cytotoxicity, and is extendedly used in the dental eld as an adhesive between the titanium screw and the ceramic crown of a dental implant.…”