Bi-directional regulation of acupuncture on extrahepatic biliary system: An approach in guinea pigs

Zhao, Jing; Yu, Yutian; Luo, Ming; Liang, Li; Rong, Peijing

doi:10.1038/s41598-017-14482-x

Cited by 11 publications

(7 citation statements)

References 25 publications

(22 reference statements)

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“…In the peripheral system, acupuncture can inhibit the contractions of Oddi's sphincter, bidirectionally regulate the gallbladder pressure, promote the secretion of hepatic bile and so on. [22][23][24][25] However, the central mechanism underlying acupuncture for BC relief still needs further investigation. Brain activity is closely correlated with the regulation of visceral function, and central integration is the key to achieving good regulation of visceral function by acupuncture.…”

Section: Strengths and Limitations Of This Studymentioning

confidence: 99%

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Immediate acupuncture with GB34 for biliary colic: protocol for a randomised controlled neuroimaging trial

Sun

He²,

et al. 2022

BMJ Open

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IntroductionAs the main manifestation of gallstone disease, biliary colic (BC) is an episodic attack that brings patients severe pain in the right upper abdominal quadrant. Although acupuncture has been documented with significance to lead to pain relief, the immediate analgesia of acupuncture for BC still needs to be verified, and the underlying mechanism has yet to be covered. Therefore, this trial aims first to verify the immediate pain-alleviation characteristic of acupuncture for BC, then to explore its influence on the peripheral sensitised acupoint and central brain activity.Methods and analysisThis is a randomised controlled, paralleled clinical trial, with patients and outcome assessors blinded. Seventy-two patients with gallbladder stone disease presenting with BC will be randomised into a verum acupuncture group and the sham acupuncture group. Both groups will receive one session of immediate acupuncture treatment. Improvements in patients’ BC will be evaluated by the Numeric Rating Scale, and the pain threshold of acupoints will also be detected before and after treatment. During treatment, brain neural activity will be monitored with functional near-infrared spectroscopy (fNIRS), and the needle sensation will be rated. Clinical and fNIRS data will be analysed, respectively, to validate the acupuncture effect, and correlation analysis will be conducted to investigate the relationship between pain relief and peripheral–cerebral functional changes.Ethics and disseminationThis trial has been approved by the institutional review boards and ethics committees of the First Teaching Hospital of Chengdu University of Traditional Chinese Medicine, with the ethical approval identifier 2019 KL-029, and the institutional review boards and ethics committees of the First People’s Hospital of Longquanyi District, with the ethical approval identifier AF-KY-2020071. The results of this trial will be disseminated through peer-reviewed publications and conference abstracts or posters.Trial registration numberCTR2000034432.

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Section: Strengths and Limitations Of This Studymentioning

confidence: 99%

“…In the peripheral system, acupuncture can inhibit the contractions of Oddi’s sphincter, bidirectionally regulate the gallbladder pressure, promote the secretion of hepatic bile and so on 22–25. However, the central mechanism underlying acupuncture for BC relief still needs further investigation.…”

Section: Introductionmentioning

confidence: 99%

Immediate acupuncture with GB34 for biliary colic: protocol for a randomised controlled neuroimaging trial

Sun

He²,

et al. 2022

BMJ Open

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“…The common acupoints for treating cholelithiasis are the gallbladder, liver, and bladder meridians, such as Danshu (BL19), Riyue (GB24), and Qiuxu (GB40). However, studies indicating the benefit of acupuncture in discharging gallstones, attributed to its strengthening effect on the gallbladder contraction and bile secretion, are limited [25–27].…”

Section: Current Situation Of Tcm Use For Cholelithiasismentioning

confidence: 99%

Mechanisms Underlying the Prevention and Treatment of Cholelithiasis Using Traditional Chinese Medicine

Chen

Zhang

et al. 2019

Evidence-Based Complementary and Alternative Medicine

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Cholelithiasis is a major public health concern that necessitates highly effective, feasible, and recurrence-preventing therapies. Currently available surgical treatments and medications cannot effectively avoid the recurrence of cholelithiasis. Hence, several Chinese herbal compounds (CHCs) are considered for the treatment of cholelithiasis, considering that they can effectively discharge gallstones and prevent the recurrence of such condition. In the present narrative review, we aim to summarize the underlying mechanisms of currently used CHCs in the treatment of cholelithiasis and to describe the current situation of traditional Chinese medicine (TCM) use for cholelithiasis. Several commonly used CHCs were used to illustrate these issues. We found that the mechanisms underlying the CHC treatments rely on the amelioration of the biliary dynamics factors, maintenance and protection of the liver function, reduction of the cholesterol and bilirubin levels, and regulation of the inflammatory reactions. CHCs as treatments based on TCM can ameliorate the overall bodily function, thereby preventing the recurrence of cholelithiasis. Appropriate application of CHCs would be beneficial for patients and clinicians, although the safety and efficacy of CHCs need further verification.

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“…e previous studies [21,22] of our research team showed that the gallbladder relaxed on a large scale after accepting acupuncture. e clinical trials and animal studies suggest that acupuncture on Yanglingquan (GB34), Qimen (LR14), and Yidan (CO11) is an effective method for regulating gallbladder motility [23,24]. Yet, the underlying mechanisms of acupuncture for gallstones remain largely unclear.…”

Section: Introductionmentioning

confidence: 99%

RNA Sequencing Analysis of Gene Expression by Electroacupuncture in Guinea Pig Gallstone Models

Hao

Dou

et al. 2022

Evidence-Based Complementary and Alternative Medicine

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Background. Clinical studies have shown that electroacupuncture (EA) promotes gallbladder motility and alleviates gallstone. However, the mechanism underlying the effects of EA on gallstone is poorly understood. In this study, the mRNA transcriptome analysis was used to study the possible therapeutic targets of EA. Methods. Hartley SPF guinea pigs were employed for the gallstone models. Illumina NovaSeq 6000 platform was used for the RNA sequencing of guinea pig gallbladders in the normal group (Normal), gallstone model group (Model), and EA-treated group (EA). Differently expressed genes (DEGs) were examined separately in Model vs. Normal and EA vs. Model. DEGs reversed by EA were selected by comparing the DEGs of Model vs. Normal and EA vs. Model. Biological functions were enriched by gene ontology (GO) analysis. The protein-protein interaction (PPI) network was analyzed. Results. After 2 weeks of EA, 257 DEGs in Model vs. Normal and 1704 DEGs in EA vs. Model were identified. 94 DEGs reversed by EA were identified among these DEGs, including 28 reversed upregulated DEGs and 66 reversed downregulated DEGs. By PPI network analysis, 10 hub genes were found by Cytohubba plugin of Cytoscape. Quantitative real-time PCR (qRT-PCR) verified the changes. Conclusion. We identified a few GOs and genes that might play key roles in the treatment of gallstone. This study may help understand the therapeutic mechanism of EA for gallstone.

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Bi-directional regulation of acupuncture on extrahepatic biliary system: An approach in guinea pigs

Cited by 11 publications

References 25 publications

Immediate acupuncture with GB34 for biliary colic: protocol for a randomised controlled neuroimaging trial

Immediate acupuncture with GB34 for biliary colic: protocol for a randomised controlled neuroimaging trial

Mechanisms Underlying the Prevention and Treatment of Cholelithiasis Using Traditional Chinese Medicine

RNA Sequencing Analysis of Gene Expression by Electroacupuncture in Guinea Pig Gallstone Models

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