Bi-cephalic parietal and cerebellar direct current stimulation interferes with early error correction in prism adaptation: Toward a complex view of the neural mechanisms underlying visuomotor control

Panico, Francesco; Sagliano, Laura; Grossi, Dario; Trojano, Luigi

doi:10.1016/j.cortex.2018.09.020

Cited by 15 publications

(8 citation statements)

References 36 publications

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“…This interpretation goes against the idea of a clear-cut separation of the involvement of distinct brain areas in PA processes as depicted in classical models (Clower et al, 1996;Redding et al, 2005;Danckert et al, 2008;Luauté et al, 2009;Chapman et al, 2010;Küper et al, 2014) and is rather in favor of dynamic interconnections between several areas. This would be in line with previous stimulation studies probing the existence of a cerebello-parietal circuitry involved in PA using multiple-sites stimulation targeting both areas either with opposite (bi-cephalic stimulation; Panico et al, 2018a) or concurrent polarities (using HD-tDCS; Panico et al, 2022). These findings were supported by neuroimaging insights that highlighted the modulation of a cerebello-parieto-parahippocampal network during PA (Schintu et al, 2020).…”

Section: Opened Perspectives From a Network Approachsupporting

confidence: 89%

Does anodal cerebellar tDCS boost transfer of after-effects from throwing to pointing during prism adaptation?

Fleury

Panico²,

Foncelle³

et al. 2022

Front. Psychol.

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Prism Adaptation (PA) is a useful method to study the mechanisms of sensorimotor adaptation. After-effects following adaptation to the prismatic deviation constitute the probe that adaptive mechanisms occurred, and current evidence suggests an involvement of the cerebellum at this level. Whether after-effects are transferable to another task is of great interest both for understanding the nature of sensorimotor transformations and for clinical purposes. However, the processes of transfer and their underlying neural substrates remain poorly understood. Transfer from throwing to pointing is known to occur only in individuals who had previously reached a good level of expertise in throwing (e.g., dart players), not in novices. The aim of this study was to ascertain whether anodal stimulation of the cerebellum could boost after-effects transfer from throwing to pointing in novice participants. Healthy participants received anodal or sham transcranial direction current stimulation (tDCS) of the right cerebellum during a PA procedure involving a throwing task and were tested for transfer on a pointing task. Terminal errors and kinematic parameters were in the dependent variables for statistical analyses. Results showed that active stimulation had no significant beneficial effects on error reduction or throwing after-effects. Moreover, the overall magnitude of transfer to pointing did not change. Interestingly, we found a significant effect of the stimulation on the longitudinal evolution of pointing errors and on pointing kinematic parameters during transfer assessment. These results provide new insights on the implication of the cerebellum in transfer and on the possibility to use anodal tDCS to enhance cerebellar contribution during PA in further investigations. From a network approach, we suggest that cerebellum is part of a more complex circuitry responsible for the development of transfer which is likely embracing the primary motor cortex due to its role in motor memories consolidation. This paves the way for further work entailing multiple-sites stimulation to explore the role of M1-cerebellum dynamic interplay in transfer.

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Section: Opened Perspectives From a Network Approachsupporting

confidence: 89%

Does anodal cerebellar tDCS boost transfer of after-effects from throwing to pointing during prism adaptation?

Fleury

Panico²,

Foncelle³

et al. 2022

Front. Psychol.

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“…Conversely, it reflects that tDCS is a technique far better characterized than most interventions [90–92] and the inherent complexity of brain function. In the context of neurorehabilitation, ongoing research is thus not directed to the general plausibility of enhancement by tDCS (as a tool to modulate excitability and plasticity) but rather specifically how to account for these nuances in order to optimize rehabilitation outcomes [93–95] including reducing variability in responsiveness [96–99].…”

Section: Physiological Basis and Functional Connectivity Of Tdcs In Mmentioning

confidence: 99%

Beyond the target area: an integrative view of tDCS-induced motor cortex modulation in patients and athletes

Morya

Monte-Silva

Bikson

et al. 2019

J NeuroEngineering Rehabil

101

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Transcranial Direct Current Stimulation (tDCS) is a non-invasive technique used to modulate neural tissue. Neuromodulation apparently improves cognitive functions in several neurologic diseases treatment and sports performance. In this study, we present a comprehensive, integrative review of tDCS for motor rehabilitation and motor learning in healthy individuals, athletes and multiple neurologic and neuropsychiatric conditions. We also report on neuromodulation mechanisms, main applications, current knowledge including areas such as language, embodied cognition, functional and social aspects, and future directions. We present the use and perspectives of new developments in tDCS technology, namely high-definition tDCS (HD-tDCS) which promises to overcome one of the main tDCS limitation (i.e., low focality) and its application for neurological disease, pain relief, and motor learning/rehabilitation. Finally, we provided information regarding the Transcutaneous Spinal Direct Current Stimulation (tsDCS) in clinical applications, Cerebellar tDCS (ctDCS) and its influence on motor learning, and TMS combined with electroencephalography (EEG) as a tool to evaluate tDCS effects on brain function.

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“…One of the most frequently reported neural correlates of sensorimotor adaptation is the parietal cortex (Inoue et al, 1997(Inoue et al, , 2000Shadmehr and Holcomb, 1997;Ghilardi et al, 2000;Krakauer et al, 2004;Graydon et al, 2005;Seidler et al, 2006;Girgenrath et al, 2008;Seidler and Noll, 2008;Luauté et al, 2009;Werner et al, 2014). Given evidence that disrupted parietal activity impairs one's ability to compensate for a sensorimotor perturbation without necessarily impacting postadaptation aftereffects (Della-Maggiore et al, 2004;Pisella et al, 2004;Panico et al, 2018), it has been suggested that this area may be selectively involved in explicit adaptation. For instance, Panico et al (2018) showed that applying either anodal or cathodal transcranial direct current stimulation (tDCS) over the parietal cortex impairs the ability to correct for target errors during prism adaptation without impacting postadaptation aftereffects.…”

Section: Introductionmentioning

confidence: 99%

“…Given evidence that disrupted parietal activity impairs one's ability to compensate for a sensorimotor perturbation without necessarily impacting postadaptation aftereffects (Della-Maggiore et al, 2004;Pisella et al, 2004;Panico et al, 2018), it has been suggested that this area may be selectively involved in explicit adaptation. For instance, Panico et al (2018) showed that applying either anodal or cathodal transcranial direct current stimulation (tDCS) over the parietal cortex impairs the ability to correct for target errors during prism adaptation without impacting postadaptation aftereffects. However, some studies have shown that parietal lesions impair both adaptation and subsequent aftereffects, suggesting that the parietal cortex may play a role in implicit adaptation as well Mutha et al, 2011a,b).…”

Section: Introductionmentioning

confidence: 99%

Single-Pulse TMS over the Parietal Cortex Does Not Impair Sensorimotor Perturbation-Induced Changes in Motor Commands

Savoie

Dallaire-Jean

Thénault

et al. 2020

eNeuro

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Intermittent exposure to a sensorimotor perturbation, such as a visuomotor rotation, is known to cause a directional bias on the subsequent movement that opposes the previously experienced perturbation. To date, it is unclear whether the parietal cortex is causally involved in this postperturbation movement bias. In a recent electroencephalogram study, Savoie et al. (2018) observed increased parietal activity in response to an intermittent visuomotor perturbation, raising the possibility that the parietal cortex could subserve this change in motor behavior. The goal of the present study was to causally test this hypothesis. Human participants (N = 28) reached toward one of two visual targets located on either side of a fixation point, while being pseudorandomly submitted to a visuomotor rotation. On half of all rotation trials, single-pulse transcranial magnetic stimulation (TMS) was applied over the right (N = 14) or left (N = 14) parietal cortex 150 ms after visual feedback provision. To determine whether TMS influenced the postperturbation bias, reach direction was compared on trials that followed rotation with (RS 1 1) and without (R 1 1) TMS. It was hypothesized that interfering with parietal activity would reduce the movement bias following rotated trials. Results revealed a significant and robust postrotation directional bias compared with both rotation and null rotation trials. Contrary to our hypothesis, however, neither left nor right parietal stimulation significantly impacted the postrotation bias. These data suggest that the parietal areas targeted here may not be critical for perturbation-induced motor output changes to emerge.

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Bi-cephalic parietal and cerebellar direct current stimulation interferes with early error correction in prism adaptation: Toward a complex view of the neural mechanisms underlying visuomotor control

Cited by 15 publications

References 36 publications

Does anodal cerebellar tDCS boost transfer of after-effects from throwing to pointing during prism adaptation?

Does anodal cerebellar tDCS boost transfer of after-effects from throwing to pointing during prism adaptation?

Beyond the target area: an integrative view of tDCS-induced motor cortex modulation in patients and athletes

Single-Pulse TMS over the Parietal Cortex Does Not Impair Sensorimotor Perturbation-Induced Changes in Motor Commands

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