Bhlhe40 limits proliferation and prevents excessive angiogenesis in mouse embryoid bodies under hypoxia
Barbara Acosta-Iborra,
Ana Isabel Gil-Acero,
Marta Sanz-Gómez
et al.
Abstract:Knowledge of the molecular mechanisms that underlie the regulation of the major adaptive responses to an unbalanced oxygen tension is central to understanding tissue homeostasis and disease. Hypoxia-inducible transcription factors (HIFs) coordinate changes in the transcriptome that control these adaptive responses. Here, we focused on the functional role of the transcriptional repressor basic-helix-loop-helix family member e40 (Bhlhe40), which we previously identified in a meta-analysis as one of the most cons… Show more
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