‘BhAVI-23’-A spice-herb based dietary infusion possessing in-vitro anti-viral potential

Saxena, Sudhanshu; Kumar, Sanjeev; Hajare, Sachin N.; Gupta, Sumit; Gautam, Satyendra; Ghosh, Sunil K.

doi:10.1016/j.jaim.2020.11.005

Cited by 7 publications

(6 citation statements)

References 69 publications

(69 reference statements)

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“…The chemical process of non-enzymatic chemical bonding between hemoglobin (Hb) and carbohydrates, such as glucose results in the development of glycated Hb and under hyperglycemic circumstances, the quantity of glycated Hb considerably increases (Saxena et al 2021). This demonstrates how the plant extracts increase the amount of free hemoglobin by decreasing the formation of the glucose-hemoglobin complex.…”

Section: Discussionmentioning

confidence: 99%

Assessment of in vitro antidiabetic properties of synthesized silver nanoparticles using ethanolic extract of Boerhavia diffusa

2023

Preprint

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The in vitro antidiabetic efficacy of ethanolic extract Boerhavia diffusa (B.diffusa) synthesized silver nanoparticles (AgNPs) was investigated by inhibition of α-amylase, α-glucosidase, protein glycation assay, non-enzymatic glycosylation of hemoglobin, glucose uptake by yeast cells and glucose diffusion at varying concentrations (10 to 100µg/ml). The alpha-amylase assay shows that the acarbose (standard) and B. diffusa had IC50 values of 46.2 µg/ml and 55.4 µg/ml, whereas alpha-glucosidase inhibitory activity was found to be 63.4 µg/ml and 93.0 µg/ml respectively. Further, non-enzymatic glycosylation analysis showed IC50 value of metformin (standard) as 28.6 µg/ml and B. diffusa as 63.9 µg/ml. The protein glycation activity was inhibited in non-enzymatic glycosylation of hemoglobin. The glycosylation was induced using pioglitazone (standard) which gives IC50 value of 616.4 µg/ml by which B. diffusa showed 756.3 µg/ml. The uptake of glucose by yeast cells was analyzed and the result shows that the glucose concentration increased steadily from 5mM to 25mM (maximum absorption) of both metronidazole (standard) and B. diffusa. From 30 to 180 minutes, the glucose diffusion experiment revealed that the concentration of the metformin and B. diffusa extract was positively correlated with the time. The ethanolic extract of synthesized AgNPs and the reference medication employed in all experiments both benefit their curative potential for the treatment of insulin resistance. The generated silver nanoparticles can be used for industrial and therapeutic purposes and can be released into the environment without harm. More in vivo study can be reviewed, however the green synthesized ethanolic extract of B. diffusa exhibits promising affect for the treatment of diabetes mellitus.

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Section: Discussionmentioning

confidence: 99%

Assessment of in vitro antidiabetic properties of synthesized silver nanoparticles using ethanolic extract of Boerhavia diffusa

2023

Preprint

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“…Eugenol appears to be able to interact with some of the virus/host proteins such as 3CL PRO , S protein, ACE2, nsp15, RdRp, and ADP ribose phosphatase, thus interfering in the viral life cycle by preventing the attachment to target cells, endocytosis, and DMV biogenesis. 86 , 105 , 106 …”

Section: Natural Products Targeting Autophagy To Halt Cell-to-cell Virus Propagationmentioning

confidence: 99%

Targeting autophagy with natural products to prevent SARS-CoV-2 infection

Vidoni

Fuzimoto

Ferraresi

et al. 2022

Journal of Traditional and Complementary Medicine

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“…In this context, herbs may possess antiviral properties owing to their phytochemical constituents. The WHO has realized that herbal medicine's health advantages can help in protecting the world population's health through traditional medicine (Saxena et al, 2021). Several studies have reported the potential role of herbs with different bioactive phytochemicals in combating many types of viruses.…”

Section: Bioactive Phytochemicalsmentioning

confidence: 99%

An Update on Herbal Bioactive Phytochemicals and their Potential Role during the COVID-19 Pandemic: A Review

El-Chaghaby

Rashad

Chavali³

2022

Basrah J. Agric. Sci.

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The current COVID-19 pandemic is the main issue globally, and finding solutions either for disease prevention or treatment is nowadays a key scientific concern. Good immunity can be shown as the only proven method of overcoming or minimizing the adverse effects of virus infections. Since Coronavirus spread, different conventional herbs were used as a traditional medication to enhance people's immunity to combat the virus. Herbs are sources of several phytochemical compounds with compelling bioactivities. A review of the studies concerning herbal plants with proven properties against viral infections is highlighted in the present work. Besides, this work also contains some of the recently published studies related to natural herbs that could be highly beneficial in preventing or treating the infection by Coronavirus. Based on the reviewed literature presented in this update, it was concluded that phytochemical constituents found in many herbs could have a potential role in preventing or treating the symptoms associated with Coronavirus infection.

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‘BhAVI-23’-A spice-herb based dietary infusion possessing in-vitro anti-viral potential

Cited by 7 publications

References 69 publications

Assessment of in vitro antidiabetic properties of synthesized silver nanoparticles using ethanolic extract of Boerhavia diffusa

Assessment of in vitro antidiabetic properties of synthesized silver nanoparticles using ethanolic extract of Boerhavia diffusa

Targeting autophagy with natural products to prevent SARS-CoV-2 infection

An Update on Herbal Bioactive Phytochemicals and their Potential Role during the COVID-19 Pandemic: A Review

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