Bhagavant Kalke and His Pioneering Work on the Bi-Leaflet Heart Valve Prosthesis

Saxena, Pankaj; Konstantinov, Igor E.

doi:10.1016/j.athoracsur.2009.02.082

Cited by 4 publications

(2 citation statements)

References 10 publications

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“…Experimental laboratory for open heart surgery at the Nair hospital had caught the eye of C Walton Lillehei during his visit to India in 1964 [6]. Besides Dr. Lillehei, who returned on several occasions (Fig.…”

Section: Making Of Indigenous Heart Lung Machinementioning

confidence: 97%

Tribute to Kersi Dastur, a pioneer in open heart surgery in India

Kalke

Magotra

2010

Indian J Thorac Cardiovasc Surg

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Section: Making Of Indigenous Heart Lung Machinementioning

confidence: 97%

Tribute to Kersi Dastur, a pioneer in open heart surgery in India

Kalke

Magotra

2010

Indian J Thorac Cardiovasc Surg

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“…The caged-ball valve was developed and implanted in the 1960s and obstructed central flow. It was replaced by tilting-disc valves in 1970 and later Kalke and Lillehei introduced the concept of bileaflet valve at the University of Minneapolis (13). The low valve profile and the improved central flow had obvious hemodynamic advantages compared to the bulky cage-ball design, particularly in the mitral position; the prosthesis was then manufactured by St-Jude Medical and implanted for the first time in 1977.…”

Section: Historical Background Of Mechanical Valvesmentioning

confidence: 99%

Evolving technology: the TRIFLO tri-leaflet mechanical valve without oral anticoagulation: a potential major innovation in valve surgery

Carrel,

Vogt,

Obrist

et al. 2023

Front. Cardiovasc. Med.

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The aortic valve is the most frequently diseased valve and aortic stenosis (AS) is the most prevalent valvular heart disease in developed countries. The diseased native aortic valve can be replaced by either a biological or mechanical valve prosthesis. The main concerns relate to durability, the need for oral anticoagulants and the incidence of complications related to this medication. Experimental, computational and biomolecular blood flow studies have demonstrated that the systolic forward flow but also the reverse flow phase at the end of the systole and leakage during the diastolic phase is mainly responsible for platelet activation and thrombosis. Better design of mechanical prosthetic heart valves must ensure smooth closing during flow deceleration and must eliminate high-shear hinge flow during diastole to prevent life-threatening thrombosis. A novel tri-leaflet valve should combine the favorable hemodynamics and the durability of existing mechanical heart valves and eliminate the less favorable characteristics, including the extremely rapid closing. In this paper, we discuss some issues of current mechanical heart valve prostheses and present a new valve design with the potential for significant innovation in the field. The TRIFLO Heart Valve, is a rigid, three-leaflet central flow heart valve prosthesis consisting of an alloyed titanium housing, and three rigid polymer (PEEK) cusps. This valve has a physiological operating mode. During the forward flow phase, the intraventricular pressure opens the leaflets so that blood can freely flow through with little obstruction, and with the deceleration of the blood flow, the leaflets close early and smoothly, minimizing blood flow regurgitation, blood cell damage, and activation of the coagulation cascade. Pre-clinical studies have shown pretty favorable results and a first-in-man study should start very soon.

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Heart Valve Disease

Siems

2023

Heart Valves

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Bhagavant Kalke and His Pioneering Work on the Bi-Leaflet Heart Valve Prosthesis

Cited by 4 publications

References 10 publications

Tribute to Kersi Dastur, a pioneer in open heart surgery in India

Tribute to Kersi Dastur, a pioneer in open heart surgery in India

Evolving technology: the TRIFLO tri-leaflet mechanical valve without oral anticoagulation: a potential major innovation in valve surgery

Heart Valve Disease

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