BGP expression in gastric biopsies may predict the development of new lesions after local treatment for early gastric cancer

Shimada, Shinya; Shiomori, Kenji; Honmyo, Ubehiko; Maeno, Masanobu; Yagi, Yasushi; Ogawa, Michio

doi:10.1007/s101200200023

Cited by 10 publications

(5 citation statements)

References 26 publications

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“…To identify these people, markers for multiple gastric cancers, such as gastric atrophy (10), microsatellite instability in cancers (11), and expression of brain-type glycogen phosphorylase in noncancerous gastric mucosae (12), have been developed. However, their sensitivity and specificity are not satisfactory, and a more sensitive marker whose value correlates with the degree of an individual's risk of cancer is awaited.…”

Section: Introductionmentioning

confidence: 99%

Higher Methylation Levels in Gastric Mucosae Significantly Correlate with Higher Risk of Gastric Cancers

Nakajima

Maekita²,

Oda

et al. 2006

Cancer Epidemiology, Biomarkers &Amp; Prevention

161

144

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Background: Helicobacter pylori infection potently induces methylation of CpG islands in gastric mucosae, which is considered to decrease to a certain level after active H. pylori infection discontinues. Noncancerous gastric mucosae of H. pylori -negative cases with a gastric cancer had higher methylation levels than those of H. pylori -negative healthy individuals. Here, using cases with multiple gastric cancers, we analyzed whether the higher methylation levels correlated with the higher risk of gastric cancers. Methods: Twenty-six healthy volunteers (HV), 30 cases with a single well-differentiated gastric cancer (S cases), and 32 cases with multiple well-differentiated gastric cancers (M cases) were recruited. H. pylori infection status was analyzed by the culture method. Methylation levels were quantified by real-time methylation-specific PCR of seven CpG islands.

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Section: Introductionmentioning

confidence: 99%

Higher Methylation Levels in Gastric Mucosae Significantly Correlate with Higher Risk of Gastric Cancers

Nakajima

Maekita²,

Oda

et al. 2006

Cancer Epidemiology, Biomarkers &Amp; Prevention

161

144

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“…In this issue of Gastric Cancer, Shimada and coworkers [5] again discuss this matter, emphasizing a possible immunohistochemical marker indicative of a high risk of development of gastric cancer, mainly applicable to patients submitted to treatment for an early carcinoma of the stomach. This study is a retrospective evaluation of the presence of brain (fetal)-type glycogen phosphorylase (BGP) in gastric mucosa with metaplasia, associated with different types of early gastric cancer.…”

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confidence: 99%

BGP expression in gastric epithelium and early gastric cancer

Castro

2002

Gastric Cancer

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nomenon indicative of the presence of a risky microenvironment, might be of some use in practice if there should be a regular association of this type of metaplasia with gastric cancer, a finding that is not always, or indeed very seldom, observed [3]. Thus, the natural history of intestinal metaplasia in the gastric mucosa continues to be doubtful in terms of its specificity in relation to gastric carcinogenesis, even when reliable methods are used for the detection of sulfated mucins. From this viewpoint, intestinal metaplasia is considered by some not to be as strongly indicative of gastric cancer as is marked atrophy of the gastric mucosa itself [4].In this issue of Gastric Cancer, Shimada and coworkers [5] again discuss this matter, emphasizing a possible immunohistochemical marker indicative of a high risk of development of gastric cancer, mainly applicable to patients submitted to treatment for an early carcinoma of the stomach. This study is a retrospective evaluation of the presence of brain (fetal)-type glycogen phosphorylase (BGP) in gastric mucosa with metaplasia, associated with different types of early gastric cancer. However, this is not their first report on the immunohistochemical detection of BGP in the metaplastic and neoplastic gastric epithelium. The same group of investigators has been studying the histopathology and the characteristics of immunoreactivity of anti-BGP antibodies in different situations. The first result of these studies dates back to 1984, when the group described the conspicuous expression of BGP in proliferative cells of intestinal metaplasia of the stomach and of well-differentiated gastric carcinoma [6]. At the time, the authors concluded that BGP expression and well-differentiated gastric adenocarcinoma may represent a more significant association than that occurring between intestinal metaplasia and gastric carcinoma. In summary, from a histological viewpoint, BGP expression by the gastric epithelium may provide a safer indication of carcinogenic potential of certain areas of the gastric epithelium.Offprint requests to: A.J.A. Barbosa

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“…With the increase of tumor malignancy, PYGB can promote cell proliferation, inhibit apoptosis, and enhance the migration and tumorigenesis of tumor cells. It is highly expressed in human colorectal cancer cells (37).Detection of PYGB during gastric biopsy may predict the occurrence and development of new lesions after local treatment of early gastric cancer (38,39). These suggest that PYGB has the function of malignant transformation of cells (40).…”

Section: Discussionmentioning

confidence: 99%

Hsa_circRNA_0059655 plays a role in salivary adenoid cystic carcinoma by functioning as a sponge of miR-338-3p

Zhao

Chen

Yang

et al. 2018

Cell Mol Biol (Noisy-le-grand)

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Circular RNAs(circRNA) are recently demonstrated to have a close relationship with tumors.To investigate the role of circular RNA in the pathogenesis of salivary adenoid cystic carcinoma(SACC), ten SACC tissues and paired normal submandibular gland(SMG) tissues were collected as the tumor group and the control group. Total RNA was extracted and then measured using ceRNA microarray (including mRNA, lncRNA, and circRNA) and miRNA microarray. Gene Ontology(GO) analysis and Kyoto Encyclopedia of Gene and Genomes (KEGG) pathway analysis were performed in order to investigate the function of the differential expressing genes. The ceRNA regulatory network was constructed to find the core circRNAs. Then the role of circRNA on proliferation was examined in the SACC cell line SACC-83 using CCK-8,qRT-PCR and western blotting, and its roles on migration and invasion were examined using wound healing assay and transwell assay. The results of the microarrays showed that 3792 mRNAs, 7649 lncRNAs, 11553 circRNAs, and 132 miRNAs expressed differentially. The ceRNA regulatory network analysis showed that hsa_circ_0059655 and other 14circRNAs derived from PYGB target on several similar genes by miR-338-3p.Among the 15 circRNAs derived from PYGB, hsa_circ_0059655has the most relationships in the ceRNA network. Furthermore, after hsa_circ_0059655 was knocked down in SACC-83 cells, the expression of hsa-miR-338-3p was up-regulated while CCND1was down-regulated. The proliferation, migration, and invasion of SACC-83 cells also decreased after hsa_circ_0059655 knock-downed.Taken together, the circRNAs derived from PYGB may regulate the tumorigenesis and development of SACC through competing with miR-338-3p.

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BGP expression in gastric biopsies may predict the development of new lesions after local treatment for early gastric cancer

Cited by 10 publications

References 26 publications

Higher Methylation Levels in Gastric Mucosae Significantly Correlate with Higher Risk of Gastric Cancers

Higher Methylation Levels in Gastric Mucosae Significantly Correlate with Higher Risk of Gastric Cancers

BGP expression in gastric epithelium and early gastric cancer

Hsa_circRNA_0059655 plays a role in salivary adenoid cystic carcinoma by functioning as a sponge of miR-338-3p

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