Beyond VEGF: Angiopoietin–Tie Signaling Pathway in Diabetic Retinopathy
Genesis Chen-Li,
Rebeca Martinez-Archer,
Andres Coghi
et al.
Abstract:Complications from diabetic retinopathy such as diabetic macular edema (DME) and proliferative diabetic retinopathy (PDR) constitute leading causes of preventable vision loss in working-age patients. Since vascular endothelial growth factor (VEGF) plays a major role in the pathogenesis of these complications, VEGF inhibitors have been the cornerstone of their treatment. Anti-VEGF monotherapy is an effective but burdensome treatment for DME. However, due to the intensive and burdensome treatment, most patients … Show more
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