Beyond the silence: Bilateral somatosensory stimulation enhances skilled movement quality and neural density in intact behaving rats

Faraji, Jamshid; Schjetnan, Andrea Gómez Palacio; Luczak, Artur; Metz, Gerlinde A. S.

doi:10.1016/j.bbr.2013.07.022

Cited by 21 publications

(20 citation statements)

References 77 publications

(122 reference statements)

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“…On the last day of testing (one day prior to electrophysiological recordings), RS was calculated for each animal (RS Control = 43.76 + 11.05, RS Stroke = 20.92 + 6.31, RS Stroke+Stim = 40.81 + 8.3). These results are consistent with previous studies showing decreased RS in rats after focal ischemia (Metz et al, 2005; Alaver- dashvili and and improvements due to anodal electrical stimulation (Adkins et al, 2008;Ukueberuwa and Wassermann, 2010;Faraji et al, 2013). RS and coherence in the gamma band were strongly correlated ( Fig.…”

Section: Coherence In Low Gamma Band Correlates With Behaviorsupporting

confidence: 92%

“…Plastic modifications elicited by tDCS have also been attributed to the actions of glial cells (Gellner et al, 2016). In a previous study conducted by our group, we show that bilateral somatosensory stimulation enhances skilled movement quality and neural density in intact behaving rats (Faraji et al, 2013). Nev-ertheless, the underlying mechanisms and neuronal correlates mediating the benefit of tDCS require further exploration to serve as a viable technique in the clinical context.…”

Section: Introductionmentioning

confidence: 77%

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Anodal transcranial direct current stimulation with monopolar pulses improves limb use after stroke by enhancing inter-hemispheric coherence

Schjetnan¹,

Gidyk²,

Metz³

et al. 2019

Acta Neurobiologiae Experimentalis

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Post-stroke neurological deficits, such as sensorimotor impairments, are often permanent and a leading cause of disability. Stroke is also associated with changes in neuronal synchrony among different brain areas. Multiple studies demonstrated that non-invasive brain stimulation, such as transcranial direct current stimulation (tDCS), enhances the efficacy of existing rehabilitative therapies. We hypothesized that the therapeutic effects of tDCS could be due to its influence on neuronal synchrony. To study this, we recorded local field potentials in rats treated with anodal tDCS (a-tDCS) after unilateral ischemic motor cortex lesion. To enhance the effect of a-tDCS on neuronal synchrony, we added monopolar pulses (a-tDCSmp) during a treatment. We found that ischemic lesions reduced interhemispheric coherence in the low gamma frequency range. By contrast, a-tDCSmp treatment increased interhemispheric coherence along with motor improvement in a skilled reaching task. These observations indicate that increased neuronal coherence is a likely mechanism by which tDCS improves stroke recovery. Moreover, this work adds to previous evidence that measures of brain coherence could be used as a biomarker of stroke recovery, which may help in the design of more effective tDCS protocols for stroke rehabilitation.

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Section: Coherence In Low Gamma Band Correlates With Behaviorsupporting

confidence: 92%

Section: Introductionmentioning

confidence: 77%

Anodal transcranial direct current stimulation with monopolar pulses improves limb use after stroke by enhancing inter-hemispheric coherence

Schjetnan¹,

Gidyk²,

Metz³

et al. 2019

Acta Neurobiologiae Experimentalis

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“…The motor cortex, in general, plays an essential role in skilled movement, postural control, and balance 57 , 58 . Close dialog between the M1 and S1 is essential not only for skilled motor function 35 , 59 – 61 , this intracortical cooperation is also supported by a wide range of afferent inputs emerging from extracortical and subcortical processing systems such as cerebellum 62 , basal ganglia 63 , and brainstem 64 . Although the cause of the reduced cortical thickness in the BTBR strain is unclear, such extensive morphological abnormality may be expected to severely disrupt sensorimotor integration, motor planning, and fine motor execution.…”

Section: Discussionmentioning

confidence: 99%

“…Three points (dorsal, lateral, and ventral) from each brain and hemisphere were selected for cortical thickness 35 . The most rostral section measured was located at ∼2.10 mm anterior to bregma and the most caudal section at ∼−0.46 mm posterior to bregma.…”

Section: Methodsmentioning

confidence: 99%

Non-diagnostic symptoms in a mouse model of autism in relation to neuroanatomy: the BTBR strain reinvestigated

et al. 2018

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Several mouse models of autism spectrum disorder (ASD), including the BTBR T + tf/J (BTBR) inbred strain, display a diverse array of behavioral deficits with particular face validity. Here we propose that phenotyping these preclinical models of ASD should avoid excessive reliance on appearance validity of the behavioral observations. BTBR mice were examined in three non-diagnostic symptoms modalities, beside an anatomical investigation for construct validity. The BTBR strain displayed poor sensorimotor integration as reflected by shorter stride length and greater latency on the balance beam task (BBT) when compared with C57BL/6 (B6) controls. Also, locomotor indices in the open-field task (OFT) revealed that BTBR mice traveled longer distances with a remarkably faster exploration than the B6 group in favor of hyperactivity and impulsiveness. Furthermore, analysis of spatial performance including search strategies in the Morris water task (MWT) indicated spatial impairment in the BTBR strain due to failure to employ spatial strategies during navigation. Quantitative cytoarchitectonics and volumetric examinations also indicated abnormal cortical and subcortical morphology in the BTBR mice. The results are discussed in relation to the neuroanatomical correlates of motor and cognitive impairments in the BTBR strain. We conclude that non-diagnostic autistic-like symptoms in the BTBR mouse strain can be impacted by autism risk factors in a similar way than the traditional diagnostic signs.

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“…However, the translation of results from the animal literature to humans is challenging because it is unclear how to transfer stimulation parameters and dose regimes to achieve comparable conditions. To date, TES research in small rodents predominantly utilizes currents at 100 to 200 µA peak-to-baseline (Grossman et al, 2017;Liebetanz et al, 2006;Monai et al, 2016;Pedron et al, 2014), while some work uses weaker inputs of 20-100 µA (Faraji et al, 2013;Wachter et al, 2011) or higher than 200 µA (Cambiaghi et al, 2011;Takano et al, 2011). TES in non-human primates typically operates at the intensity of 1-2 mA (Kar et al, 2017;Krause et al, 2017).…”

Section: Introductionmentioning

confidence: 99%

Comparative Modeling of Transcranial Magnetic and Electric Stimulation in Mouse, Monkey, and Human

Alekseichuk

Mantell

Shirinpour

et al. 2018

Preprint

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Transcranial magnetic stimulation (TMS) and transcranial electric stimulation (TES) are increasingly popular methods to noninvasively affect brain activity. However, their mechanism of action and doseresponse characteristics remain under active investigation. Translational studies in animals play a pivotal role in these efforts due to a larger neuroscientific toolset enabled by invasive recordings. In order to translate knowledge gained in animal studies to humans, it is crucial to generate comparable stimulation conditions with respect to the induced electric field in the brain. Here, we conduct a finite element method (FEM) modeling study of TMS and TES electric fields in a mouse, capuchin monkey, and human model.We systematically evaluate the induced electric fields and analyze their relationship to head and brain anatomy. We find that with increasing head size, TMS-induced electric field strength first increases and then decreases according to a two-term exponential function. TES-induced electric field strength strongly decreases from smaller to larger specimen with up to 100x fold differences across species. Our results can serve as a basis to compare and match stimulation parameters across studies in animals and humans. KEYWORDSTranscranial magnetic stimulation; transcranial electric stimulation; finite element modeling; animal models HIGHLIGHTS • Translational research in brain stimulation should account for large differences in induced electric fields in different organisms • We simulate TMS and TES electric fields using anatomically realistic finite element models in three species: mouse, monkey, and human• TMS with a 70 mm figure-8 coil creates an approximately 2-times weaker electric field in a mouse brain than in monkey and human brains, where electric field strength is comparable • Two-electrode TES creates an approximately 100-times stronger electric field in a mouse brain and 3.5-times stronger electric field in a monkey brain than in a human brain

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Beyond the silence: Bilateral somatosensory stimulation enhances skilled movement quality and neural density in intact behaving rats

Cited by 21 publications

References 77 publications

Anodal transcranial direct current stimulation with monopolar pulses improves limb use after stroke by enhancing inter-hemispheric coherence

Anodal transcranial direct current stimulation with monopolar pulses improves limb use after stroke by enhancing inter-hemispheric coherence

Non-diagnostic symptoms in a mouse model of autism in relation to neuroanatomy: the BTBR strain reinvestigated

Comparative Modeling of Transcranial Magnetic and Electric Stimulation in Mouse, Monkey, and Human

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