Beyond the Risk of Biofilms: An Up-and-Coming Battleground of Bacterial Life and Potential Antibiofilm Agents

Zeineldin, Mohamed; Esmael, Ahmed; Al-Hindi, Rashad R.; Alharbi, Mona G.; Bekele, Debebe Ashenafi

doi:10.3390/life13020503

Cited by 8 publications

(5 citation statements)

References 182 publications

(175 reference statements)

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“…The residual aqueous extract from seeds (RaQS extract) was found to inhibit the biofilm formation, primarily due to its ability to prevent adhesion without affecting the planktonic bacteria [ 59 ]. The phytoextracts and volatile essential oils are known to hamper biofilm production using several different mechanisms, such as damaging the membrane and the membrane proteins forming leaky channels and inhibiting ATP production, interrupting the signals, and thereby the communication between cells [ 133 , 134 ]. Plants produce a variety of secondary metabolites that are useful against a variety of human pathogenic bacteria.…”

Section: Methods Of Combating Biofilmsmentioning

confidence: 99%

Microbial Biofilms: Applications, Clinical Consequences, and Alternative Therapies

Ali,

Zahra,

Kamthan

et al. 2023

Microorganisms

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Biofilms are complex communities of microorganisms that grow on surfaces and are embedded in a matrix of extracellular polymeric substances. These are prevalent in various natural and man-made environments, ranging from industrial settings to medical devices, where they can have both positive and negative impacts. This review explores the diverse applications of microbial biofilms, their clinical consequences, and alternative therapies targeting these resilient structures. We have discussed beneficial applications of microbial biofilms, including their role in wastewater treatment, bioremediation, food industries, agriculture, and biotechnology. Additionally, we have highlighted the mechanisms of biofilm formation and clinical consequences of biofilms in the context of human health. We have also focused on the association of biofilms with antibiotic resistance, chronic infections, and medical device-related infections. To overcome these challenges, alternative therapeutic strategies are explored. The review examines the potential of various antimicrobial agents, such as antimicrobial peptides, quorum-sensing inhibitors, phytoextracts, and nanoparticles, in targeting biofilms. Furthermore, we highlight the future directions for research in this area and the potential of phytotherapy for the prevention and treatment of biofilm-related infections in clinical settings.

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Section: Methods Of Combating Biofilmsmentioning

confidence: 99%

Microbial Biofilms: Applications, Clinical Consequences, and Alternative Therapies

Ali,

Zahra,

Kamthan

et al. 2023

Microorganisms

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“…Exotoxins present in the matrix are responsible for this, and the most common classes are transferases, hydrolases, lyases, and redox enzymes [ 148 ]. A well-known example of this mechanism is the β-lactamases secreted by K. pneumoniae biofilms, which destroy ampicillin and prevent it from reaching the cells [ 149 ]. Another example is the case of S. aureus that can produce β-lactamase enzymes, which degrade β-lactam antibiotics like penicillin.…”

Section: Biofilm Tolerance/resistance To Traditional Antimicrobialsmentioning

confidence: 99%

Emerging Approaches for Mitigating Biofilm-Formation-Associated Infections in Farm, Wild, and Companion Animals

Araújo,

Silva,

Fernandes

et al. 2024

Pathogens

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The importance of addressing the problem of biofilms in farm, wild, and companion animals lies in their pervasive impact on animal health and welfare. Biofilms, as resilient communities of microorganisms, pose a persistent challenge in causing infections and complicating treatment strategies. Recognizing and understanding the importance of mitigating biofilm formation is critical to ensuring the welfare of animals in a variety of settings, from farms to the wild and companion animals. Effectively addressing this issue not only improves the overall health of individual animals, but also contributes to the broader goals of sustainable agriculture, wildlife conservation, and responsible pet ownership. This review examines the current understanding of biofilm formation in animal diseases and elucidates the complex processes involved. Recognizing the limitations of traditional antibiotic treatments, mechanisms of resistance associated with biofilms are explored. The focus is on alternative therapeutic strategies to control biofilm, with illuminating case studies providing valuable context and practical insights. In conclusion, the review highlights the importance of exploring emerging approaches to mitigate biofilm formation in animals. It consolidates existing knowledge, highlights gaps in understanding, and encourages further research to address this critical facet of animal health. The comprehensive perspective provided by this review serves as a foundation for future investigations and interventions to improve the management of biofilm-associated infections in diverse animal populations.

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“…Как известно, масло «Дыши» -это композиция из шести натуральных эфирных масел (эвкалиптовое, мятное, каепутовое, гвоздичное, винтергриновое, можжевеловое) и левоментола (АО «АКВИОН»), обладающих антисептическими, противовоспалительными и тонизирующими свой ствами. Важное значение использование композиций эфирных масел и их паров имеет в борьбе с биопленочными и персистирующими инфекциями [21]. Как выше указывалось, нами были получены данные о способности паров масла «Дыши» подавлять персистентный потенциал условно-патогенных бактерий и дрожжеподобных грибов путем снижения их способности к биопленкообразованию и инактивации лизоцима (антилизоцимная активность -АЛА) на популяционном уровне [16].…”

Section: результаты и обсуждениеunclassified

Microbiological justification of the advisability of using essential oils of medicinal plants in the treatment of inflammatory diseases of the upper respiratory tract

Ivanova,

Danilova,

Chainikova

et al. 2023

Medicinskij sovet

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Introduction. The role of the respiratory tract microflora violations as an etiological and pathogenetic factor in the development of the inflammative upper respiratory tract disease is indisputable, and the importance of persistence factors of respiratory opportunistic microorganisms (URT) is high. The traditional use of antibiotics and antimycotic agents in the pathology of URT has failed due to a significant increase in the number of antibiotic-resistant strains of microorganisms and the development of a number of undesirable adverse reactions in patients. An alternative advantage in these conditions is belonged to herbal preparations.Aim. To conduct a comparative in vitro study of antibacterial and antifungal activities of the plant essential oils as a component of the Dyshi Oil composition and the Dyshi Oil composition itself against opportunistic microorganisms - causative agents of inflammatory upper airway diseases.Materials and methods. Essential oils of clove, juniper, peppermint, eucalyptus, as well as the composition of oils “Dyshi” were used in the work. Staphylococcus aureus ATCC 25923, Klebsiella pneumoniae ICIS-278, Pseudomonas aeruginosa ATCC 27853, and Candida albicans ATCC 24433 bacterial cultures were used as test cultures. Staphylococcus epidermidis 25 strain, isolated from a conditionally healthy person, was chosen as a representative of the URT normobiota. Antimicrobial activity of essential oils was determined by the method of diffusion in nutrient agar, MIC - by the method of serial dilutions.Results. The presence of zones of pronounced growth retardation of Staphylococcus aureus, Klebsiella and Pseudomonas, as well as yeast-like fungi was established when exposed to the composition of “Dyshi” oils, while separately used oils did not have a visible effect on the growth of bacteria and fungi, which indicates a synergistic interaction of the drug oils components.Conclusion. The presence of a synergistic antimicrobial effect of the “Dyshi” oil composition against opportunistic bacteria and yeast-like fungi of the genus Candida has been proven. The absence of an inhibitory effect on the growth of Staphylococcus epidermidis, which is a representative of the upper respiratory tract normobiota indicates a possible selective effect of “Dyshi” oil aimed at maintaining the colonization resistance of the URT biotope.

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Beyond the Risk of Biofilms: An Up-and-Coming Battleground of Bacterial Life and Potential Antibiofilm Agents

Cited by 8 publications

References 182 publications

Microbial Biofilms: Applications, Clinical Consequences, and Alternative Therapies

Microbial Biofilms: Applications, Clinical Consequences, and Alternative Therapies

Emerging Approaches for Mitigating Biofilm-Formation-Associated Infections in Farm, Wild, and Companion Animals

Microbiological justification of the advisability of using essential oils of medicinal plants in the treatment of inflammatory diseases of the upper respiratory tract

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