Beyond the Numbers: Interpreting WHO's Global Tuberculosis Report 2016 to Inform TB Policy and Practice in the East African Community

Sabiiti, Wilber

doi:10.24248/eahrj-d-16-00364

Cited by 7 publications

(10 citation statements)

References 13 publications

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“…Even when Mozambique achieves the required capacity of six culture laboratories, samples will need to be transported over a distance of >20 000 km 2 and at high ambient temperatures [ 5 ]. The situation is not different in many other resource-limited high-burden TB countries [ 21 , 22 ].…”

Section: Discussionmentioning

confidence: 99%

OMNIgene.SPUTUM suppresses contaminants while maintainingMycobacterium tuberculosisviability and obviates cold-chain transport

Azam

Cadir²,

Madeira

et al. 2018

ERJ Open Res

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Tuberculosis (TB) diagnostics are centralised, requiring long-distance transportation of specimens in most resource-limited settings. We evaluated the ability of OMNIgene.SPUTUM (OM-S) to obviate cold-chain transport of TB specimens.A two-arm (same-day and after 5 days sample processing) study was conducted to assess contamination rates and Mycobacterium tuberculosis viability in OM-S-treated samples against the standard decontamination procedure (SDP) in Mozambique, using Lowenstein Jensen (LJ) and mycobacterial growth indicator tube (MGIT) culture and molecular bacterial load assay.270 specimens were processed using OM-S and SDP in same-day and 5-day arms. Contamination was lower in OM-S-treated than SDP-treated cultures: 12% versus 15% and 2% versus 27% in the same-day and 5-day arms, respectively. M. tuberculosis recovery in OM-S-treated LJ cultures was 10% and 56% higher in the same-day and 5-day arms, respectively, than SDP-treated cultures, but lower in MGIT (52% and 28% lower in the same-day and 5-day arms, respectively). M. tuberculosis viable count was 1log estimated CFU·mL−1 lower in 5-day OM-S-treated sputa. OM-S was more effective at liquefying sputum with a shorter sample processing time: 22 min for culture.OM-S is simple to use and has demonstrated a high potency to suppress contaminants, maintenance of viability at ambient temperatures and higher M. tuberculosis recovery, particularly in the solid LJ cultures. Optimisation of OM-S to achieve higher MGIT culture positivity and shorter time to result will increase its application and utility in the clinical management of TB.

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Section: Discussionmentioning

confidence: 99%

OMNIgene.SPUTUM suppresses contaminants while maintainingMycobacterium tuberculosisviability and obviates cold-chain transport

Azam

Cadir²,

Madeira

et al. 2018

ERJ Open Res

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“…Tuberculosis (TB) has prevailed for millennia and remains a major health problem worldwide ( Sabiiti and consortium, 2017 ). Increasing incidences of multidrug resistant cases of TB are a major threat.…”

Section: Molecular Docking Simulation Of Amentoflavone Through In Silico Approachmentioning

confidence: 99%

Insights Into Amentoflavone: A Natural Multifunctional Biflavonoid

Xiong

Tang²,

Lai³

et al. 2021

Front. Pharmacol.

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Amentoflavone is an active phenolic compound isolated from Selaginella tamariscina over 40 years. Amentoflavone has been extensively recorded as a molecule which displays multifunctional biological activities. Especially, amentoflavone involves in anti-cancer activity by mediating various signaling pathways such as extracellular signal-regulated kinase (ERK), nuclear factor kappa-B (NF-κB) and phosphoinositide 3-kinase/protein kinase B (PI3K/Akt), and emerges anti-SARS-CoV-2 effect via binding towards the main protease (Mpro/3CLpro), spike protein receptor binding domain (RBD) and RNA-dependent RNA polymerase (RdRp) of SARS-CoV-2. Therefore, amentoflavone is considered to be a promising therapeutic agent for clinical research. Considering the multifunction of amentoflavone, the current review comprehensively discuss the chemistry, the progress in its diverse biological activities, including anti-inflammatory, anti-oxidation, anti-microorganism, metabolism regulation, neuroprotection, radioprotection, musculoskeletal protection and antidepressant, specially the fascinating role against various types of cancers. In addition, the bioavailability and drug delivery of amentoflavone, the molecular mechanisms underlying the activities of amentoflavone, the molecular docking simulation of amentoflavone through in silico approach and anti-SARS-CoV-2 effect of amentoflavone are discussed.

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“…Consequently, there is an urgent need to necessitate culturally sensitive health education on TB disease targeting men to clarify any myths and misperceptions and enhance positive attitudes towards TB disclosure. Poverty is the second reported determinant that hampers TB treatment and care 45 70. This study has shown that men, often the primary earners in their families, might prioritise work over seeking medical care due to the fear of lost wages or the inability to support their families during illness.…”

Section: Discussionmentioning

confidence: 99%

Gendered gaps to tuberculosis prevention and care in Kenya: a political economy analysis study

Abdullahi,

Oketch,

Komen

et al. 2024

BMJ Open

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BackgroundTuberculosis (TB) remains a public health concern in Kenya despite the massive global efforts towards ending TB. The impediments to TB prevention and care efforts include poor health systems, resource limitations and other sociopolitical contexts that inform policy and implementation. Notably, TB cases are much higher in men than women. Therefore, the political economy analysis (PEA) study provides in-depth contexts and understanding of the gender gaps to access and successful treatment for TB infection.DesignPEA adopts a qualitative, in-depth approach through key informant interviews (KII) and documentary analysis.Setting and participantsThe KIIs were distributed among government entities, academia, non-state actors and community TB groups from Kenya.ResultsThe themes identified were mapped onto the applied PEA analysis framework domains. The contextual and institutional issues included gender concerns related to the disconnect between TB policies and gender inclusion aspects, such as low prioritisation for TB programmes, limited use of evidence to inform decisions and poor health system structures. The broad barriers influencing the social contexts for TB programmes were social stigma and cultural norms such as traditional interventions that negatively impact health-seeking behaviours. The themes around the economic situation were poverty and unemployment, food insecurity and malnutrition. The political context centred around the systemic and governance gaps in the health system from the national and devolved health functions.ConclusionBroad contextual factors identified from the PEA widen the disparity in targeted gender efforts toward men. Following the development of effective TB policies and strategies, it is essential to have well-planned gendered responsive interventions with a clear implementation plan and monitoring system to enhance access to TB prevention and care.

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Beyond the Numbers: Interpreting WHO's Global Tuberculosis Report 2016 to Inform TB Policy and Practice in the East African Community

Cited by 7 publications

References 13 publications

OMNIgene.SPUTUM suppresses contaminants while maintainingMycobacterium tuberculosisviability and obviates cold-chain transport

OMNIgene.SPUTUM suppresses contaminants while maintainingMycobacterium tuberculosisviability and obviates cold-chain transport

Insights Into Amentoflavone: A Natural Multifunctional Biflavonoid

Gendered gaps to tuberculosis prevention and care in Kenya: a political economy analysis study

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