Beyond the Granuloma: New Insights into Cardiac Sarcoidosis Using Spatial Proteomics
Eliot Peyster,
David Smith,
Therese Bittermann
et al.
Abstract:Cardiac sarcoidosis is poorly understood, challenging to diagnose, and portends a poor prognosis. A lack of animal models necessitates the use of residual human samples to study sarcoidosis, which in turn necessitates the use of analytical tools compatible with archival, fixed tissue. We employed high-plex spatial protein analysis within a large cohort of archival human cardiac sarcoidosis and control tissue samples, studying the immunologic, fibrotic, and metabolic landscape of sarcoidosis at different stages… Show more
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