Beyond the diaphragm and the lung: a multisystem approach to understanding congenital diaphragmatic hernia

NF-κB Signaling in Congenital Diaphragmatic Hernia: A Potential Therapeutic Strategy?

“…CDH is characterized by lung hypoplasia with impaired branching morphogenesis, reduction in alveolar development, and abnormal vascular remodeling. This lung hypoplasia is part of a global embryopathy (affecting lung development even before diaphragm development) and is a multisystem disorder rather than due solely to the mechanical effects of compression by abdominal contents in the chest ( 2 – 4 ). In this issue of the Journal , Dylong and colleagues (pp.…”