Beyond the Conventional Role of External-Beam Radiation Therapy for Skeletal Metastases: New Technologies and Stereotactic Directions

Yu, H-H M; Hoffe, Sarah E.

doi:10.1177/107327481201900207

Cited by 14 publications

(1 citation statement)

References 49 publications

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“…[72] A systematic review showed SBRT provided excellent local control with lower toxicity in patients with metastatic renal cell carcinoma. [73] Although pain relief is higher in in SBRT, cost effectiveness of SBRT in comparison with EBRT in patients with a shorter expected survival (<11 months) remains contested.…”

Section: 4 Therapeutic Management Of Cibpmentioning

confidence: 99%

Bone Pain and Muscle Weakness in Cancer Patients

Milgrom

Lad

Koniaris

et al. 2017

Curr Osteoporos Rep

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Purpose of review In this article we will discuss the current understanding of bone pain and muscle weakness in cancer patients. We will describe the underlying physiology and mechanisms of cancer-induced bone pain (CIBP) and cancier-induced muscle wasting (CIMW), as well as current methods of diagnosis and treatment. We will discuss future therapies and research directions to help patients with these problems. Recent Findings There are several pharmacologic therapies that are currenly in pre-clinical and clinical testing that appear to be promising adjuncts to current CIBP and CIMW therapies. Such therapies include resiniferitoxin, which is a targeted inhibitor of nociptive nerve fibers, and selective androgen receptor modulators, which show promise in increasing lean mass. Summary CIBP and CIMW are a significant causes of morbidity in affected patients. Current management is mostly palliative; however, targeted therapies are poised to revolutionize how these problems are treated.

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Section: 4 Therapeutic Management Of Cibpmentioning

confidence: 99%