Beyond the CNS: The many peripheral roles of APOE

Martínez-Martínez, Ana Belén; Torres-Pérez, Elena; Devanney, Nicholas; Moral, Raquel del; Johnson, Lance A.; Arbonés-Mainar, José M.

doi:10.1016/j.nbd.2020.104809

“…APOA1 levels have also been shown to be significantly decreased in severe COVID-19 patients 55 . APOE is a gene that encodes a lipid binding protein involved in cholesterol metabolism 56 . Preliminary evidence suggests that the e4 allele of APOE may lead to a higher risk of deep vein thrombosis and the same allele also predicts severe COVID-19 57,58 .…”

Section: Discussion and Summarymentioning

confidence: 99%

Investigation of COVID-19 comorbidities reveals genes and pathways coincident with the SARS-CoV-2 viral disease

Dolan

¹

,

Hill

²

,

Mukherjee

³

et al. 2020

Sci Rep

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The emergence of the SARS-CoV-2 virus and subsequent COVID-19 pandemic initiated intense research into the mechanisms of action for this virus. It was quickly noted that COVID-19 presents more seriously in conjunction with other human disease conditions such as hypertension, diabetes, and lung diseases. We conducted a bioinformatics analysis of COVID-19 comorbidity-associated gene sets, identifying genes and pathways shared among the comorbidities, and evaluated current knowledge about these genes and pathways as related to current information about SARS-CoV-2 infection. We performed our analysis using GeneWeaver (GW), Reactome, and several biomedical ontologies to represent and compare common COVID-19 comorbidities. Phenotypic analysis of shared genes revealed significant enrichment for immune system phenotypes and for cardiovascular-related phenotypes, which might point to alleles and phenotypes in mouse models that could be evaluated for clues to COVID-19 severity. Through pathway analysis, we identified enriched pathways shared by comorbidity datasets and datasets associated with SARS-CoV-2 infection.

show abstract

“…APOA1 levels have also been shown to be significantly decreased in severe COVID-19 patients 55 . APOE is a gene that encodes a lipid binding protein involved in cholesterol metabolism 56 . Preliminary evidence suggests that the e4 allele of APOE may lead to a higher risk of deep vein thrombosis and the same allele also predicts severe COVID-19 57 , 58 .…”

Section: Discussion and Summarymentioning

confidence: 99%

Investigation of COVID-19 comorbidities reveals genes and pathways coincident with the SARS-CoV-2 viral disease

Dolan

¹

,

Hill

²

,

Mukherjee

³

et al. 2020

Preprint

View full text Add to dashboard Cite

The emergence of the SARS-CoV-2 virus and subsequent COVID-19 pandemic initiated intense research into the mechanisms of action for this virus. It was quickly noted that COVID-19 presents more seriously in conjunction with other human disease conditions such as hypertension, diabetes, and lung diseases. We conducted a bioinformatics analysis of COVID-19 comorbidity-associated gene sets, identifying genes and pathways shared among the comorbidities, and evaluated current knowledge about these genes and pathways as related to current information about SARS-CoV-2 infection. We performed our analysis using GeneWeaver (GW), Reactome, and several biomedical ontologies to represent and compare common COVID-19 comorbidities. Phenotypic analysis of shared genes revealed significant enrichment for immune system phenotypes and for cardiovascular-related phenotypes, which might point to alleles and phenotypes in mouse models that could be evaluated for clues to COVID-19 severity. Through pathway analysis, we identified enriched pathways shared by comorbidity datasets and datasets associated with SARS-CoV-2 infection.

show abstract

“…ApoE serves as a ligand for the clearance of triglyceride-rich ApoB-containing lipoproteins by binding to membrane lipoprotein receptors in the LDL receptor family. [46][47][48][49] ApoE has many genetic variants affecting health and disease. 50,51 The most common isoform, ApoE3 has a Cys at codon 112 and Arg at codon 158.…”

Section: Apoe and Covid-19mentioning

confidence: 99%