Beyond the Biomarker: Unveiling the Multifaceted Role of Osteopontin in Both Physiological and Pathological Processes

Raineri, Davide; Chiocchetti, Annalisa; Cappellano, Giuseppe

doi:10.3390/biomedicines12050982

Biomedicines

2024

DOI: 10.3390/biomedicines12050982

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Beyond the Biomarker: Unveiling the Multifaceted Role of Osteopontin in Both Physiological and Pathological Processes

Davide Raineri,

Annalisa Chiocchetti,

Giuseppe Cappellano

Abstract: Osteopontin (OPN), a multifunctional protein, has emerged as a fascinating subject of study due to its diverse roles in various physiological and pathological processes [...]

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2024

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Cited by 2 publications

References 27 publications

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Osteopontin: A Versatile Biomarker—Insights and Innovations from Three Decades of Research

Abreu,

Cappellano

2024

Biomedicines

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Osteopontin: A Versatile Biomarker—Insights and Innovations from Three Decades of Research

Abreu,

Cappellano

2024

Biomedicines

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Biomarkers That Seem to Have the Greatest Impact on Promoting the Formation of Atherosclerotic Plaque in Current Scientific Research

Kłosowicz,

Leksa,

Bartusik-Aebisher

et al. 2024

CIMB

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Atherosclerosis is a chronic inflammatory disease that causes degenerative and productive changes in the arteries. The resulting atherosclerotic plaques restrict the vessel lumen, causing blood flow disturbances. Plaques are formed mainly in large- and medium-sized arteries, usually at bends and forks where there is turbulence in blood flow. Depending on their location, they can lead to various disease states such as myocardial infarction, stroke, renal failure, peripheral vascular diseases, or sudden cardiac death. In this work, we reviewed the literature on the early detection of atherosclerosis markers in the application of photodynamic therapy to atherosclerosis-related diseases. Herein, we described the roles of C-reactive protein, insulin, osteopontin, osteoprotegerin, copeptin, the TGF-β cytokine family, and the amino acid homocysteine. Also, we discuss the role of microelements such as iron, copper, zinc, and Vitamin D in promoting the formation of atherosclerotic plaque. Dysregulation of the administered compounds is associated with an increased risk of atherosclerosis. Additionally, taking into account the pathophysiology of atherosclerotic plaque formation, we believe that maintaining homeostasis in the range of biomarkers mentioned in this article is crucial for slowing down the process of atherosclerotic plaque development and the stability of plaque that is already formed.

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Beyond the Biomarker: Unveiling the Multifaceted Role of Osteopontin in Both Physiological and Pathological Processes

Abstract: Osteopontin (OPN), a multifunctional protein, has emerged as a fascinating subject of study due to its diverse roles in various physiological and pathological processes [...]

Cited by 2 publications

References 27 publications

Osteopontin: A Versatile Biomarker—Insights and Innovations from Three Decades of Research

Osteopontin: A Versatile Biomarker—Insights and Innovations from Three Decades of Research

Biomarkers That Seem to Have the Greatest Impact on Promoting the Formation of Atherosclerotic Plaque in Current Scientific Research

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