Beyond Restenosis

Abstract

Background-In the first year after coronary stent implantation, clinical failures are driven mainly by procedural complications and restenosis, but the subsequent relative contributions of restenosis and disease progression to late failures are less clear. Methods and Results-We observed 1228 patients for 5 years after the implantation of stents as part of pivotal second-generation coronary stent trials. Clinical events of death, myocardial infarction, repeat revascularization, and repeat hospitalization for acute coronary syndrome or congestive heart failure were attributed to the index stented (target) lesion or other distinct sites (either in the target or other coronary vessels) and further classified as procedural, restenosis, or nonrestenosis. During the first year the hazard rate was 18.3% for target-lesion events and 12.4% for events unrelated to the target lesion. After the first year the average annual hazard rate was 1.7% for target-lesion events and 6.3% for nontarget-lesion events. By the fifth year, restenosis events occurred in 20.3% of patients, whereas 30-day procedural complications or later nonrestenosis events occurred in 37.9%, including 11.4% who also experienced a restenosis event, for a combined cumulative event rate of 46.4%. Diabetes mellitus and multivessel disease were independently associated with increased risk for both restenosis and nonrestenosis events. Conclusion-In a low-risk clinical trial population, the clinical outcome beyond 1 year after stenting is determined by a high rate of events related to disease progression in segments other than the stented lesion, which itself remains relatively stable.

Bare-metal stent outcomes in an unselected patient population

“…Cutlip et al analyzed 5-year follow-up data for 1,288 randomized patients in stent trials and observed that after the first year the hazard rate for stented lesion events (including death, infarction, and revascularization) was 1.7% while that related to nonstented lesions was 6.3%. 3 Accordingly, to quantify the need for revascularization related to in-stent restenosis, we examined the angiographic data from catheterization laboratory readmissions in patients who received BMS prior to the market release of DES.…”

Clinical Relevance of Functionally Insignificant Moderate Coronary Artery Stenosis Assessed by 3‐Vessel Fractional Flow Reserve Measurement

“…Previous studies16, 17 demonstrate that a substantial proportion of late events occur in nontarget lesions and that CAD burden confers a significant risk for plaque progression. In the BASKET‐PRO (Basel Stent Kosten‐Effektivitäts Trial ‐Progression of CAD) study,18 37.1% of late clinical events occurred in the nontarget vessels.…”

Early and long-term outcomes of coronary bypass in patients with previous percutaneous coronary intervention

“…По данным разных авторов [7][8][9][10][11][12], от 15 до 30% пациентов с рестенозом стентов и реци-дивом стенокардии после ЧКВ подвергаются повторным ангиопластикам и 20-25% направляются на КШ без по-пыток эндоваскулярного лечения. При проведении по-вторных вмешательств риск рестеноза в КА прогрессивно увеличивается пропорционально числу процедур и дости-гает 50-53% [13,14], в конечном итоге этих пациентов направляют на операцию КШ.…”