Beyond probiotic legend: ESSAP gut microbiota health score to delineate SARS-COV-2 infection severity

Abstract

The COVID-19 pandemic continues to be a global health crisis. The gut microbiome critically affects the immune system and some respiratory infections are associated with changes in the gut microbiome, here we evaluated the role of nutritional and lifestyle habits that modulate gut microbiota on COVID-19 outcomes in a longitudinal cohort study that included 200 consecutive patients infected with COVID-19. Of these, 122 cases were mild and 78 were moderate, according to WHO classification. After detailed explanation by a consultant in clinical nutrition, participants responded to a written questionnaire on daily sugar, probiotic and prebiotic intake in food, sleeping hours, exercise duration, and antibiotic prescription, during the past one year before infection. daily consumption of prebiotic-containing foods, less sugar, regular exercise, adequate sleep, and fewer antibiotic prescriptions, led to a milder disease and rapid virus clearance. Additionally, data on these factors were compiled into a single score, the ESSAP score (Exercise, Sugar consumption, Sleeping hours, Antibiotics taken, and Probiotics and Prebiotics administration; 0–11 points), median ESSAP score was 5 for both mild and moderate cases; however, the range was 4–8 in mild cases but 1–6 in moderate (p = 0.001, OR:4.2, 95%CI:1.9-9.1), our results showed a negative correlation between regular consumption of yogurt containing probiotics and disease severity (p = 0.007, OR:1.6, 95%CI:1.1-2.1). Mild COVID-19 disease was associated with 10-20 minutes of daily exercise (p = 0.016), sleeping at least 8 hours daily prescribed antibiotics less than 5 times per year (p = 0.077), ate plenty of prebiotic-containing food.

Role of the Microbiome in the Pathogenesis of COVID-19

“…Hegazy et al already found conclusive evidence that a healthy gut microbiome leads to better outcome in COVID-19 ( Hegazy et al., 2021 ). They conducted a longitudinal study in COVID-19 patients to evaluate the role of factors like nutrients and lifestyle, which modulate gut microbiome ( Hegazy et al., 2021 ). They found a negative correlation between the consumption of probiotic food and the severity of COVID-19 ( Hegazy et al., 2021 ).…”

“…The commensals can also be exploited as pre- and probiotics for the prevention and treatment of COVID-19. Momentous strides have been made in this direction ( Hegazy et al., 2021 ). Hegazy et al already found conclusive evidence that a healthy gut microbiome leads to better outcome in COVID-19 ( Hegazy et al., 2021 ).…”

“…Momentous strides have been made in this direction ( Hegazy et al., 2021 ). Hegazy et al already found conclusive evidence that a healthy gut microbiome leads to better outcome in COVID-19 ( Hegazy et al., 2021 ). They conducted a longitudinal study in COVID-19 patients to evaluate the role of factors like nutrients and lifestyle, which modulate gut microbiome ( Hegazy et al., 2021 ).…”

Patient Nutrition and Probiotic Therapy in COVID-19: What Do We Know in 2021?

“…Some respiratory infections are related to dysbiotic alterations of gut microbiota. Hegazy et al investigated the role of nutritional and lifestyle habits in the context of modulation of gut microbiota and COVID-19 outcomes [145]. This study included 200 COVID-19 patients.…”

“…It was noted that daily consumption of foods containing prebiotics, as well as less sugar, regular physical activity, and adequate sleep, is associated with milder disease and rapid clearance of the virus. The authors concluded that the aforementioned factors can potentially modulate the gut microbiome, and the severity of the disease may be reduced [145].…”