Beyond Obesity: The Rising Incidence and Mortality Rates of Uterine Corpus Cancer

Mullins, Megan; Coté, Michele L.

doi:10.1200/jco.19.01240

Cited by 21 publications

(23 citation statements)

References 35 publications

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Section: Discussionmentioning

confidence: 79%

“…Even with the current rise of NCDs in the US mainland, the prevalence of uterine cancer in the general population is still perceived to be less than the prevalence of breast cancer among women on SERMs 13,14 . However, in some populations, as demonstrated here for American Samoa, the incidence of uterine cancer may exceed that of breast cancer 14,15 . Although it is not higher than breast cancer in the general US mainland population, the prevalence of uterine cancer in American Samoa is similar to that of other cancers that generally have screening programs (e.g., breast, colon, prostate, and cervical cancer).…”

Section: Discussionmentioning

confidence: 79%

“…Screening modality must also be confirmed prospectively, but due to the poor PPV of sonography, endometrial sampling of some kind is likely to play a role. Currently, there are highly sensitive and specific potential screening methods for detection that may be effective in reducing mortality 14–18 . In the future, newer methods may displace endometrial histologic sampling as their costs rapidly decrease 19 …”

Section: Discussionmentioning

confidence: 99%

“…Nevertheless, the present report of a notable change in traditional cancer burden should spur efforts from all stakeholders to evaluate current practices and optimize population health for their specific international communities. High‐income countries may already be experiencing the rise of uterine cancer and its consequences 14,15 …”

Section: Discussionmentioning

confidence: 99%

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The rising relative and absolute incidence of uterine cancer in specific populations

Timoteo-Liaina

Khozaim

Chen

et al. 2020

Intl J Gynecology & Obste

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Objective To assess the contemporary incidence of cancers using American Samoa as a learning set for insights into similar populations. Methods A retrospective observational analysis of de‐identified data held in public‐access databases (2004–2014) and data on uterine cancer from a hospital, both in American Samoa (2015–2016). Results There were 341 new cases of cancer in 2004–2014 (111 per 100 000 women/year), including breast (20.2%), uterine (19.4%), and cervical (5.0%); and 287 in 2011–2015 (103 per 100 000 women/year), including uterine (24.0%), breast (18.5%), and cervical (5.2%). Uterine cancer increased from 21.4 to 60.3 per 100 000 women/year, becoming the most common cancer in American Samoa. In 2011–2015, the incidence‐rate ratio of uterine cancer to other cancers in American Samoa was 1.3‐, 3.8‐, 4.6‐, 7.7‐, and 23‐fold higher than breast, colon, cervical, ovarian, and lung cancer, respectively. Among the most recent cases (n=33), median age was 55 years (10 [30.3%] <50 years), median BMI was 38.2; and 11 (33.3%) cases had grade 3 histology. Conclusion The pattern of cancers in American Samoa differs from that in the US mainland. The findings reflect significant changes in cancer incidence. Cancer control programs should evaluate the potential of uterine screening in accordance with their community's needs and characteristics.

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Section: Discussionmentioning

confidence: 79%

Section: Discussionmentioning

confidence: 79%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 2 more Smart Citations

The rising relative and absolute incidence of uterine cancer in specific populations

Timoteo-Liaina

Khozaim

Chen

et al. 2020

Intl J Gynecology & Obste

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“…Finally, as we performed a population-based analysis, our findings apply directly to an unselected collective where the treatment effect becomes directly apparent. As the number of cases with endometrial cancer rose in recent years, the population effect of treatment interventions is especially relevant from a public health perspective [ 38 ]. Here, the rise of non-endometroid cancers might pose a challenge to future treatment guidelines [ 34 , 38 ].…”

Section: Discussionmentioning

confidence: 99%

Effect of Radiotherapy in Addition to Surgery in Early Stage Endometrial Cancer: A Population-Based Study

Medenwald

Langer

Gottschick

et al. 2020

Cancers

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Background: The role of radiotherapy in the management of early (FIGO I) endometrial cancer is controversial with limited availability of prospective data from randomized trials. Methods: German Epidemiologic Cancer Registries provided by the Robert Koch Institute. We considered FIGO I cases with recorded operative treatment (n = 12,718, 2000–2017). We computed hazard ratios (HR) from relative survival models in relation to the mortality of the general population with 95% confidence intervals (CI). Multivariate models were adjusted for age, stage (IA vs. IB), grading, and chemotherapy. Radiotherapy included external radiotherapy and brachytherapy. Results: Cases with a favorable risk profile (FIGO IA, G1/G2) had a slightly lower survival rate, relative to the general population (FIGO IA: 0.9, G1: 0.91). The proportion of FIGO IA cases was lower in the radiotherapy group (52.6%) vs. cases without radiotherapy (78.6%). Additional treatment with radiotherapy was beneficial in FIGO IB (HR = 0.74) and all histopathological grades, but not FIGO IA cases (HR = 0.93) cases. Compared to IA tumors, IB cases had a HR of 1.51 (95% CI: 1.34–1.7). Conclusions: Radiotherapy in addition to surgery is beneficial for patients in a FIGO IB stage. Further studies need to address the impact of new techniques and risk assessment.

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Annual report to the nation on the status of cancer, part 1: National cancer statistics

Cronin

Scott

Firth

et al. 2022

Cancer

243

129

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Background: The American Cancer Society, the Centers for Disease Control and Prevention, the National Cancer Institute, and the North American Association of Central Cancer Registries collaborate to provide annual updates on cancer occurrence and trends in the United States. Methods: Data on new cancer diagnoses during 2001-2018 were obtained from the North American Association of Central Cancer Registries' Cancer in North America Incidence file, which is comprised of data from Centers for Disease Control and Prevention-funded and National Cancer Institute-funded, populationbased cancer registry programs. Data on cancer deaths during 2001-2019 were obtained from the National Center for Health Statistics' National Vital StatisticsSystem. Five-year average incidence and death rates along with trends for all cancers combined and for the leading cancer types are reported by sex, racial/ ethnic group, and age.Results: Overall cancer incidence rates were 497 per 100,000 among males (ranging from 306 among Asian/Pacific Islander males to 544 among Black males) and 431 per 100,000 among females (ranging from 309 among Asian/ Pacific Islander females to 473 among American Indian/Alaska Native females) during 2014-2018. The trend during the corresponding period was stable among males and increased 0.2% on average per year among females, with differing trends by sex, racial/ethnic group, and cancer type. Among males, incidence rates increased for three cancers (including pancreas and kidney), were stable for seven cancers (including prostate), and decreased for eight (including lung and larynx) of the 18 most common cancers considered in thisThis is an open access article under the terms of the Creative Commons Attribution-NonCommercial License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.

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Beyond Obesity: The Rising Incidence and Mortality Rates of Uterine Corpus Cancer

Cited by 21 publications

References 35 publications

The rising relative and absolute incidence of uterine cancer in specific populations

The rising relative and absolute incidence of uterine cancer in specific populations

Effect of Radiotherapy in Addition to Surgery in Early Stage Endometrial Cancer: A Population-Based Study

Annual report to the nation on the status of cancer, part 1: National cancer statistics

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