Beyond Low Earth Orbit: Biomonitoring, Artificial Intelligence, and Precision Space Health

Scott, Ryan T.; Antonsen, Erik L.; Sanders, Lauren; Hastings, Jaden J. A.; Park, Seung Min; Mackintosh, Graham; Reynolds, Robert J.; Hoarfrost, Adrienne; Sawyer, Aenor; Greene, Casey S.; Glicksberg, Benjamin S.; Theriot, Corey A.; Berrios, Daniel C.; Miller, Jack M.; Babdor, Joël; Barker, Richard J.; Baranzini, Sergio E.; Beheshti, Afshin; Chalk, Stuart; Delgado-Aparicio, Guillermo M.; Haendel, Melissa; Hamid, Arif; Heller, Philip H.; Jamieson, Daniel; Jarvis, Katelyn; Kalantari, John; Khezeli, Kia; Komarova, Svetlana V.; Komorowski, Matthieu; Kothiyal, Prachi; Mahabal, A.; Manor, Uri; Martín, Héctor García; Mason, Christopher E.; Matar, Mona; Mias, George I.; Myers, Samuel L.; Nelson, Charlotte L.; Oribello, Jonathan; Parsons‐Wingerter, Patricia; Prabhu, R. K.; Qutub, Amina A.; Rask, Jon; Saravia-Butler, Amanda; Saria, Suchi; Singh, Nitin K.; Soboczenski, Frank; Snyder, M; Soman, Karthik; Venkateswaran, Kasthuri; Warren, Liz; Worthey, Liz; Yang, Jason H.; Žitnik, Marinka; Costes, Sylvain V.

doi:10.48550/arxiv.2112.12554

Cited by 3 publications

(6 citation statements)

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“…Investigations and knowledge of space microbiology is particularly important for space safety ( Mermel, 2013 ; Bijlani et al, 2021 ), biotechnology development ( Cockell, 2022 ), resource and waste recycling ( Lindeboom et al, 2018 ). Technologies from diverse disciplines such as nanotechnologies, bioinformatics ( Schmidt and Goodwin, 2013 ; Castro-Wallace et al, 2017 ) and artificial intelligence (AI; Scott et al, 2021 ; Madrigal et al, 2022 ) have been and are being applied for space life investigations. Established (LSDA, EEA, GeneLab, etc.)…”

Section: Discussionmentioning

confidence: 99%

Database of space life investigations and bioinformatics of microbiology in extreme environments

Wang

Zeng

et al. 2022

Front. Microbiol.

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Biological experiments performed in space crafts like space stations, space shuttles, and recoverable satellites has enabled extensive spaceflight life investigations (SLIs). In particular, SLIs have revealed distinguished space effects on microbial growth, survival, metabolite production, biofilm formation, virulence development and drug resistant mutations. These provide unique perspectives to ground-based microbiology and new opportunities for industrial pharmaceutical and metabolite productions. SLIs are with specialized experimental setups, analysis methods and research outcomes, which can be accessed by established databases National Aeronautics and Space Administration (NASA) Life Science Data Archive, Erasmus Experiment Archive, and NASA GeneLab. The increasing research across diverse fields may be better facilitated by databases of convenient search facilities and categorized presentation of comprehensive contents. We therefore developed the Space Life Investigation Database (SpaceLID) http://bidd.group/spacelid/, which collected SLIs from published academic papers. Currently, this database provides detailed menu search facilities and categorized contents about the studied phenomena, materials, experimental procedures, analysis methods, and research outcomes of 448 SLIs of 90 species (microbial, plant, animal, human), 81 foods and 106 pharmaceuticals, including 232 SLIs not covered by the established databases. The potential applications of SpaceLID are illustrated by the examples of published experimental design and bioinformatic analysis of spaceflight microbial phenomena.

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Section: Discussionmentioning

confidence: 99%

Database of space life investigations and bioinformatics of microbiology in extreme environments

Wang

Zeng

et al. 2022

Front. Microbiol.

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“…Numerous discoveries are being made as a result of new medical technology, and an interest in individual differences among spaceflight participants is paving the way for personalised space medicine [12], [13]. Because acute care knowledge and skills drive the design of medical systems to meet future missions' in-flight medical needs, technological advancement advances by focusing on operational and user needs [13], [14]. Algorithm advancement may facilitate striking the proper balance between technological progress and the provision of more specialised applications.…”

Section: B Humanised Intelligencementioning

confidence: 99%

“…Before being integrated into space-based medical systems, AI must be clinically robust for monitoring, diagnosis, treatment, and guidance [4]. The precision space health system [13] or other potential space health applications [14], [16] are examples showing the expected level of intelligence.…”

Section: B Humanised Intelligencementioning

confidence: 99%

How Space Operations Drive Innovation In Human Healthcare

Cinelli

2023

IEEE Open J. Eng. Med. Biol.

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Appropriate healthcare during human spaceflight necessitates adequate capabilities throughout the mission. This paper aims to raise awareness about how operations impact healthcare innovation. Future missions beyond low-Earth orbit will fundamentally alter healthcare, and advancements in space medicine will drive innovation in the field. Space agencies rely on evidence-based approaches to maximise the impact of innovation and make it safe for use in space. However, a lack of human readiness levels delays the inclusion of humans in the technology development process and can prevent the identification of human health hazards. This creates difficulties for the commercial space sector when attempting to apply the government's evidencebased approaches. As a result, medical capabilities for spaceflight could be developed independently of operations and vehicle/system design. Creating a safety framework necessitates alignment between these domains and may promote improved technology transfer of spaceflight medical capability to terrestrial medical needs.

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“…These approaches could model the physiological impact that mission parameters, such as duration and radiation exposure, may have on individual astronauts. 36 , 37 Although there are a few interesting exceptions, at present, most AI approaches require large volumes of high-quality and domain-relevant training data. 38 , 39 , 40 Notably, robust population-based analyses will be particularly challenging to achieve for humans in space, given their rarity.…”

Section: Considerations For a European Space Research Routine Omics P...mentioning

confidence: 99%

“…Measures taken in flight across different time points could then eventually be compared with the baseline data with ML approaches to predict health outcomes and suggest preventative interventions. 37 , 52 Insights related to the molecular impact of mission events, such as EVA, could also be used to inform mission design, or indeed day-to-day task scheduling to manage stress responses.…”

Section: Considerations For a European Space Research Routine Omics P...mentioning

confidence: 99%

Routine omics collection is a golden opportunity for European human research in space and analog environments

et al. 2022

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Beyond Low Earth Orbit: Biomonitoring, Artificial Intelligence, and Precision Space Health

Cited by 3 publications

References 0 publications

Database of space life investigations and bioinformatics of microbiology in extreme environments

Database of space life investigations and bioinformatics of microbiology in extreme environments

How Space Operations Drive Innovation In Human Healthcare

Routine omics collection is a golden opportunity for European human research in space and analog environments

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