Beyond Limitations: Practical Strategies for Improving Cancer Care in Nigeria

Eguzo, Kelechi; Camazine, Brian

doi:10.7314/apjcp.2013.14.5.3363

Cited by 13 publications

(15 citation statements)

References 8 publications

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“…Improvements in survival may be possible with promotion of early presentation through outreach and education programs teaching providers in rural areas about the signs and symptoms of cancer. Several such efforts are being piloted in Africa aiming to reduce delayed presentation . Our data did not show a high rate of treatment‐related mortality, with most known causes of death related to tumor.…”

Section: Discussionmentioning

confidence: 52%

Survival of children with endemic Burkitt lymphoma in a prospective clinical care project in Uganda

McGoldrick

Mutyaba

Adams

et al. 2019

Pediatric Blood & Cancer

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Purpose “Endemic” Burkitt lymphoma (BL) is a common childhood cancer in Africa. Social and treatment factors may contribute to poor survival. With the aim of improving BL outcomes in Uganda, we undertook a comprehensive project (BL Project) that provided diagnostic support, access to standard chemotherapy, nutritional evaluations, and case management. We evaluated survival of children with BL in the context of the project. Patients and methods Patients followed by the BL Project who consented to research were enrolled in this study. Children with a pathology diagnosis consistent with BL were eligible. Data were collected prospectively. First‐line chemotherapy generally consisted of six cycles of cyclophosphamide, vincristine, low‐dose methotrexate (COM). We used Kaplan–Meier and Cox regression analyses to evaluate factors associated with overall survival (OS). Results Between July 2012 and June 2017, 341 patients with suspected BL presented to the BL Project. One hundred eighty patients with a pathology‐based diagnosis were included in this study. The median age was seven years (interquartile range, 5–9), 74% lived ≥100 km from the Uganda Cancer Institute, 61% had late‐stage disease, 84% had ECOG performance status < 3, 63% reported B‐symptoms, and 22% showed neurologic symptoms. Fewer than 10% abandoned therapy. The four‐year OS rate was 44% (95% CI, 36%–53%). In a multivariate model, ECOG status was significantly associated with mortality. Conclusion The BL Project reduced effects of lacking supportive care and oncology resources, and allowed patients from Uganda to receive curative intent therapy with minimal loss to follow‐up. Nonetheless, OS remains unacceptably low. Improved therapeutic approaches to endemic BL are urgently needed in Africa.

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Section: Discussionmentioning

confidence: 52%

Survival of children with endemic Burkitt lymphoma in a prospective clinical care project in Uganda

McGoldrick

Mutyaba

Adams

et al. 2019

Pediatric Blood & Cancer

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“…The low disease-related health literacy will lead to late presentation of cases and increased disease burden, when little can be done. At present the emphasis is to raise disease-related awareness to overcome ever-increasing burden of the disease (Hamptom et al, 2008;Harirchi et al, 2012;Eguzo and Camazine, 2013). The prevalence of health behaviors was still low.…”

Section: Discussionmentioning

confidence: 99%

Status and Determinants of Health Literacy among Adolescents in Guangdong, China

Ye¹,

Yang²,

Gao³

et al. 2014

Asian Pacific Journal of Cancer Prevention

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Background: Previous studies for non-communicable disease cotrol, including cancer, have mostly relied on health literacy in adults. However, limited studies are available for adolescents. This study aimed to assess the status and determinants of health literacy in in-school adolescents in Guangdong, China. Materials and Methods: A total of 3,821 students aged 13-25 years were selected by multi-stage cluster sampling. After the questionnaire of health literacy was answered, the total scores for health knowledge (18 questions), skills (5 questions) and behaviors (14 questions) were determined. The total scores for health literacy and each subscale were recoded into adequate and inadequate subgroups, and logistic regression models were used to identify factors associated with each outcome variable. Results: The prevalence of adequate health literacy was 14.4%, and the prevalences for adequate knowledge, skills and behavior were 22.4%, 64.7% and 6.6%, respectively. Students coming from prestigious schools and having parents with higher education had higher odds of having adequate knowledge, skills and behaviors. Female students had higher odds of having adequate knowledge and behaviors. Students in grade 7-8 had higher odds of having adequate knowledge and skills. The health knowledge was positive associated with health skills (odds ratio [OR] =2.1, 95% confidence interval [CI] 1.7-2.5) and behaviors (OR=3.0, 95%CI 2.3-4.0), and health skills were positive associated with health behaviors (OR=2.6, 95%CI 1.8-3.8). Conclusions: Further efforts should be made to increase adolescents' health knowledge and behaviors, especially for low grade and male students in non-prestigious schools.

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“…Although several studies have shown reductions in risk factors such as BP and cholesterol (Yusuf and others 2009) and improvement in adherence in association with use of a polypill, no published study has shown reductions in IHD or stroke endpoints, although several studies are under way (Eguzo and Camazine 2013;Lonn and others 2010;Yusuf and others 2009). The use of combination therapy was shown to be cost-effective in LMICs for both primary and secondary prevention, with the best cost-effectiveness ratio for secondary prevention (Gaziano and others 2005;Lim and others 2007).…”

Section: Cost and Cost-effectiveness Of Interventionsmentioning

confidence: 99%

Management of Hypertension and Dyslipidemia for Primary Prevention of Cardiovascular Disease

Jeemon¹,

Gupta²,

Onen³

et al. 2017

Disease Control Priorities, Third Edition (Volume 5): Cardiovascular, Respiratory, and Related Disorders

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Table 22.2 Pharmacological Agents Available as Generics for Controlling Hypertension and Reducing Cardiovascular Risk in Many Countries Class Common examples (alphabetic) Angiotensin-converting enzyme inhibitors Captopril, enalapril, lisinopril, perindopril, ramipril Angiotensin receptor blockers Candesartan, losartan, olmesartan, telmisartan, valsartan Calcium channel blockers Amlodipine, cilnidipine, lercanidipine, nifedipine Diuretics (thiazides and thiazide-like) Bendroflumethiazide, chlorthalidone, chlorothiazide, hydrochlorothiazide, indapamide Beta blockers Atenolol, bisoprolol, carvedilol, metoprolol, nebivolol, propranolol Mineralocorticoid receptor antagonists Eplerenone, spironolactone Alpha blockers Doxazosin, prazosin Others Clonidine, hydralazine, methyldopa, minoxidil, reserpine Note: Preferred antihypertensive drugs in women of reproductive age with intention for conception and for pregnant and breastfeeding women are methyldopa, nifedipine, and hydralazine.

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Beyond Limitations: Practical Strategies for Improving Cancer Care in Nigeria

Cited by 13 publications

References 8 publications

Survival of children with endemic Burkitt lymphoma in a prospective clinical care project in Uganda

Survival of children with endemic Burkitt lymphoma in a prospective clinical care project in Uganda

Status and Determinants of Health Literacy among Adolescents in Guangdong, China

Management of Hypertension and Dyslipidemia for Primary Prevention of Cardiovascular Disease

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